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Novel laboratory model may shine light on development of pediatric high-grade glioma

Pediatric high-grade glioma is the primary cause of cancer death in children. Genesis of these tumors is believed to be driven by mutations in proteins that disrupt fundamental mechanisms governing the development of the human brain.

27 Oct 2017

Osteocytes play crucial role as major source of RANKL during orthodontic tooth movement

Tokyo Medical and Dental University research team demonstrated that osteocytes have a crucial role in orthodontic tooth movement as the major source of receptor activator of nuclear factor-κB ligand (RANKL), a protein crucial to bone remodeling.

23 Oct 2017

Two studies set groundwork for new avenues to treat influenza and anthrax poisoning

Two recent studies led by biologists at the University of California San Diego have set the research groundwork for new avenues to treat influenza and anthrax poisoning

17 Oct 2017

Study opens door to new approach for curing HIV infections

In findings that open the door to a completely different approach to curing HIV infections, scientists from the Florida campus of The Scripps Research Institute have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells, and prevents viral rebound, even when those infected cells are subjected to vigorous stimulation.

17 Oct 2017

New topical treatment to combat skin cancer yields promising results in preliminary study

Researchers at the University of São Paulo (USP), in Brazil, are testing a technique in mice that combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy to treat skin cancer.

6 Oct 2017

Penn study explains how acute viral infections can linger

Infections caused by viruses, such as respiratory syncytial virus, or RSV, measles, parainfluenza, and Ebola, are typically considered acute. These viruses cause disease quickly and live within a host for a limited time. But in some cases, the effects of the infection, and presence of the virus itself, can persist.

6 Oct 2017

New microcapsules represent promising vectors for application of genome-editing tools

Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient in genome-editing when applying CRISPR-Cas9 system.

6 Oct 2017

Markey's cancer researcher wins NIH's New Innovator Award

University of Kentucky Markey Cancer Center Researcher Jessica Blackburn has earned a prestigious National Institutes of Health's New Innovator Award, a grant totaling $1.5 million over five years to fund pediatric cancer research.

6 Oct 2017

New DNA-based Zika vaccine demonstrates safety and ability to elicit immune response

A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans, according to new research from the Perelman School of Medicine at the University of Pennsylvania, conducted in partnership with The Wistar Institute, Inovio Pharmaceuticals, and GeneOne Life Science, Inc.

5 Oct 2017

Symprove could offer safe and efficient solution to control pathogenic bacteria

Leading food technology company, Symprove Ltd, has demonstrated with three breakthrough studies that their formula has the unique ability to have an antagonistic effect on pathogenic bacteria such as C. difficile, Escherichia coli (AIEC), Shigella sonnei and MRSA.

4 Oct 2017

Scientists manipulate living cells to produce fluorinated bioplastics

Natural organic compounds that contain fluorine are rare because living organisms—with a few exceptions—do not produce them.

4 Oct 2017

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

4 Oct 2017

Researchers produce fluorinated molecules in living cells

Natural organic compounds that contain fluorine are rare because living organisms—with a few exceptions—do not produce them. American scientists have now genetically engineered a microbial host for organofluorine metabolism, allowing it to produce a fluoridated intermediate known as a diketide.

30 Sep 2017

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Osaka Researchers, in partnership with other Japanese and U.S. scientists, report a new gene target, KPNB1, for treatment against epithelial ovarian cancer (EOC).

28 Sep 2017

Study presents new method for tracing history of β-cells

Tracing the history of individual cells in the developing organism can reveal functional differences among seemingly uniform cells. This knowledge is important for defining the characteristics of highly regenerative cells in order to target them for cellular therapies, as well as to prevent the formation of unfit cells, which compromise the overall health of the organism.

22 Sep 2017

Neurohistology: how whole slide scanning impacts workflow

MultiBrain technology can accelerate the R&D preclinical and safety assessment processes many fold and perform them less expensively.

From Huron Digital Pathology 21 Sep 2017

Study identifies slowly proliferating and highly invasive melanoma cells

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior. The research was published in the journal Oncogene.

21 Sep 2017

'Small intestinal permeable peptides' improve biopharmaceuticals absorption in digestive tract

Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, resulting in a bottleneck for oral administration type biopharmaceutical development.

20 Sep 2017

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

For a cancer drug to be successful, it needs to reach the malignant tumor site. Researchers in Japan have now found a way for increasing the effectiveness of drug delivery to certain types of brain tumors, by packing epirubicin, a known antitumor agent, in specially designed polymeric micelles.

13 Sep 2017

Caltech researchers develop miniature device for use in ‘smart pills’ to diagnose and treat diseases

Researchers at Caltech have developed a prototype miniature medical device that could ultimately be used in "smart pills" to diagnose and treat diseases.

12 Sep 2017

in vivo News and Research

Novel laboratory model may shine light on development of pediatric high-grade glioma

Osteocytes play crucial role as major source of RANKL during orthodontic tooth movement

Two studies set groundwork for new avenues to treat influenza and anthrax poisoning

Study opens door to new approach for curing HIV infections

New topical treatment to combat skin cancer yields promising results in preliminary study

Penn study explains how acute viral infections can linger

New microcapsules represent promising vectors for application of genome-editing tools

Markey's cancer researcher wins NIH's New Innovator Award

New DNA-based Zika vaccine demonstrates safety and ability to elicit immune response

Symprove could offer safe and efficient solution to control pathogenic bacteria

Scientists manipulate living cells to produce fluorinated bioplastics

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Researchers produce fluorinated molecules in living cells

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Study presents new method for tracing history of β-cells

Neurohistology: how whole slide scanning impacts workflow

Study identifies slowly proliferating and highly invasive melanoma cells

'Small intestinal permeable peptides' improve biopharmaceuticals absorption in digestive tract

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

Caltech researchers develop miniature device for use in ‘smart pills’ to diagnose and treat diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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