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Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Scientists unravel novel role of signalling protein in common type of liver cancer

The most common type of liver cancer, called Hepatocellular carcinoma, is one of the most prevalent tumours worldwide.

21 Dec 2016

Rice bioengineers reveal how heart valves use different strategies to handle oxygen starvation

As the valves in a heart stretch with each beat, their cells take in life-giving oxygen. But if the supply is cut off, aortic and mitral valves use different strategies to compensate, according to Rice University scientists.

21 Dec 2016

AXT makes magnetic particle imaging technology available to researchers in Australia

AXT is proud to be able to bring another cutting-edge technology to Australia that will help our medical researchers accelerate the rate at which they bring new cures, remedies and therapies to clinical realities.

From AXT Pty Ltd 21 Dec 2016

Scientists develop better material to regenerate bone tissue cells in shorter time

A new study has revealed a technology how to cover biodegradable implants with a human skeleton similar mineral.

20 Dec 2016

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Developing brains in newborns have a sizable pool of a certain type of immature progenitor cell that can be expanded and induced to replace cells lost to brain injury.

19 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Lactate component responsible for anti-tumor effects of plasma medicine, research shows

Physical plasma is one of the four fundamental states of matter, together with solid, liquid, and gas, and can be completely or partially ionized (thermal/hot or non-thermal/cold plasma, respectively).

15 Dec 2016

Novel plasma medicine with anti-tumor effect discovered

Nagoya University researchers develop cold plasma-activated Ringer's solution for chemotherapy. The solution has anti-tumor effects in vitro and in vivo that derive from the lactate component.

14 Dec 2016

RNA modifications play significant role in function of nervous system

Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have shown that a new way of regulating genes is vital for the activity of the nervous system.

8 Dec 2016

Research reveals opposing role for SNAP23 protein in endocrine and exocrine pancreas

Movement of secretory molecules, such as hormones and digestive enzymes, out of the cell is known as exocytosis. This process is guided by SNARE proteins, which help the fusion of secretory vesicles with the plasma membrane.

8 Dec 2016

Leti researchers show memristive devices can emulate short- and long-term synaptic plasticity

Leti researchers have demonstrated that memristive devices are excellent candidates to emulate synaptic plasticity, the capability of synapses to enhance or diminish their connectivity between neurons, which is widely believed to be the cellular basis for learning and memory.

8 Dec 2016

New chemosensor offers better sensitivity in detecting biomarker for cancer and inflammatory diseases

A new technique offers better sensitivity and accuracy in detecting an essential biomarker of cancer and inflammatory diseases.

7 Dec 2016

Starvation may shorten lifespans of children and male descendants, study suggests

New Tel Aviv University research suggests that periods of fasting or starvation may significantly shorten the lifespans of both children and their male descendants.

5 Dec 2016

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Pericytes are the primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary damage and blood leakage during ischemia, according to preclinical findings reported by Medical University of South Carolina investigators in an article published online on November 14, 2016 by The Journal of Neuroscience.

5 Dec 2016

Researchers assess scientific rigor in animal experimentation

The "reproducibility crisis" in biomedical research has led to questions about the scientific rigor in animal research, and thus the ethical justification of animal experiments.

2 Dec 2016

UC San Diego scientists reveal surprising role for Hippo pathway in subduing tumor immunogenicity

Previous studies identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, but new research led by University of California San Diego School of Medicine scientists reveals a surprising role for these enzymes in subduing cancer immunity. The findings, published in Cell on December 1, could have a clinical role in improving efficiency of immunotherapy drugs.

1 Dec 2016

Monell Center receives Gates Foundation grant to support innovative global health research project

The Monell Center announced today that it has received a $345,000 grant from the Bill & Melinda Gates Foundation. The grant supports an innovative global health research project titled, "Developing Novel Pediatric Formulation Technologies for Global Health: Human Taste Assays."

1 Dec 2016

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations.

1 Dec 2016

in vivo News and Research

Generative AAE can be radically new way to discover drugs on demand

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists unravel novel role of signalling protein in common type of liver cancer

Rice bioengineers reveal how heart valves use different strategies to handle oxygen starvation

AXT makes magnetic particle imaging technology available to researchers in Australia

Scientists develop better material to regenerate bone tissue cells in shorter time

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Researchers identify attractive drug candidate to target glioma tumors

Lactate component responsible for anti-tumor effects of plasma medicine, research shows

Novel plasma medicine with anti-tumor effect discovered

RNA modifications play significant role in function of nervous system

Research reveals opposing role for SNAP23 protein in endocrine and exocrine pancreas

Leti researchers show memristive devices can emulate short- and long-term synaptic plasticity

New chemosensor offers better sensitivity in detecting biomarker for cancer and inflammatory diseases

Starvation may shorten lifespans of children and male descendants, study suggests

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Researchers assess scientific rigor in animal experimentation

UC San Diego scientists reveal surprising role for Hippo pathway in subduing tumor immunogenicity

Monell Center receives Gates Foundation grant to support innovative global health research project

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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