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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

Unique life science-focused application for social media site launched

19. November 2009 03:07
Sigma-Aldrich® today announced the launch of a unique life science-focused application for the social media site, Facebook. Developed and marketed by Sigma® Life Science, the 'What's Your Favorite Gene?' application is the first and currently only application of its kind available on Facebook, and provides a platform that can enable scientists and researchers to network with each other and facilitate discussion based on their favorite genes, identifiable via gene functionality and biological pathways. [More]

Posted in: Device / Technology News | Medical Science News

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New pre-clinical data from Alnylam Pharmaceuticals' ALN-VSP program presented

18. November 2009 07:38
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, today announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. [More]

RXi Pharmaceuticals announces financial results for the quarter ended September 30, 2009

16. November 2009 07:51
RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today reported its financial results for the quarter ended September 30, 2009. [More]

Posted in: Business / Finance

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Update on Alnylam Pharmaceuticals' RNAi pipeline, platform, and technology

12. November 2009 08:09
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, is providing an update on its RNAi pipeline, platform, and technology at its R&D Day being held in New York today. [More]

Review of Mersana Therapeutics's lead compound, XMT-1001 to be published

12. November 2009 07:38
Mersana Therapeutics, a platform-based cancer therapeutics company, announced today that a review of the Company's lead compound, XMT-1001, will appear in the November 12, 2009 special issue of Advanced Drug Delivery Reviews on Polymer Therapeutics: Clinical Applications and Challenges for Development. [More]

Posted in: Medical Condition News | Pharmaceutical News

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Alnylam Pharmaceuticals presents new data related to its overall delivery research efforts

5. November 2009 07:41
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it presented new data related to its overall delivery research efforts including the rational design of Mimetic Lipoprotein Particles, or MLPs, a novel technology for the systemic delivery of small interfering RNAs, or siRNAs, the molecules that mediate RNAi. [More]

Sigma-Aldrich, Polyplus-transfection sign licensing agreement to manufacture ZNA oligonucleotides

3. November 2009 23:58
Sigma-Aldrich today announced a worldwide licensing agreement with Polyplus-transfection (Strasbourg, France) to manufacture and commercialize Zip Nucleic Acid (ZNA(TM)) oligonucleotides, a new technology that provides solutions for increased affinity for nucleic acids. [More]

Posted in: Device / Technology News

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Arrowhead Research updates its shareholders

3. November 2009 08:13
Arrowhead Research Corporation’s (NASDAQ: ARWR) President and Chief Executive Officer today issued the following letter to the Company’s shareholders. [More]

Posted in: Business / Finance

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Report on the future of RNAi-based therapeutics & diagnostics

2. November 2009 11:27
Research and Markets (http://www.researchandmarkets.com/research/8f18b5/delivering_rnaiba) has announced the addition of the "Delivering RNAi-Based Therapeutics & Diagnostics: Challenges & Opportunities" report to their offering. [More]

Posted in: Device / Technology News

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KOKEN receives license to manufacture and provide RNAi research products under Kreutzer-Limmer patent family

27. October 2009 08:38
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, and KOKEN Co., Ltd., a leading atelocollagen company, announced today that Alnylam has granted KOKEN a non-exclusive worldwide license to manufacture and provide RNAi research products and services under the Kreutzer-Limmer patent family. [More]

Posted in: Business / Finance

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Quark Pharmaceuticals receives a Japanese patent for its hypoxia regulated genes

27. October 2009 06:04
Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced issuance of Japanese Patent Number: 4354633, titled, "Hypoxia regulated genes," on August 7, 2009. [More]

RXi Pharmaceuticals presents new preclinical data from its advanced RNAi therapeutic platform

9. October 2009 06:49
RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today announced the presentation of new preclinical data from its advanced RNAi therapeutic platform at its Annual Investor Event held in New York City on Monday, October 5, 2009. [More]

Posted in: Medical Science News

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RXi receives USPTO notices of allowance for certain siRNA sequence-specific patent applications

3. October 2009 07:03
RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today announced that Notices of Allowance were recently issued by the United States Patent Office (USPTO) on patent applications filed by Thermo Fisher Scientific Inc. and licensed to RXi Pharmaceuticals encompassing small interfering RNA (siRNA) sequences targeting superoxide dismutase (SOD1), Amyloid beta (A4) precursor protein (APP), interleukin-1 receptor-associated kinase 4 (IRAK4), hepatocyte growth factor receptor (MET protooncogene) and cyclin-dependent kinase (cdk) inhibitor p27 (also known as Kip1, CDKN1B). [More]

Posted in: Medical Patent News

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Liquidia founder Dr. Joseph DeSimone honoured with the NIH Director’s Pioneer Award

24. September 2009 08:58
Liquidia Technologies today announced its founder, Dr. Joseph DeSimone, has received the National Institutes of Health (NIH) Director’s Pioneer Award. Pioneer Awards are designed to support individual scientists of exceptional creativity who propose pioneering – and possibly transforming – approaches to major challenges in biomedical and behavioral research. [More]

Posted in: Miscellaneous News

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NIH awards three UNC Scientists for high risk and innovative research

24. September 2009 05:23
Three scientists from the University of North Carolina at Chapel Hill School of Medicine and the UNC Lineberger Comprehensive Cancer Center have received prestigious awards from the National Institutes of Health (NIH) aimed at encouraging "high risk" and innovative research. [More]
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