The NanoRacer® High-Speed AFM represents a significant advancement in the quantitative imaging field. It has never been simpler to visualize dynamic biological processes in real time with nanometer resolution.
Researchers can now gain a comprehensive understanding of intricate biological systems and molecular mechanisms in a way that has never been possible before, thanks to the NanoRacer, which opens up a whole new world of innovative and exciting possibilities for life science applications.
Benefits
Exceptional
50 fps and 5000 lines/second
Lowest force imaging with a small cantilever capability for minimal sample damage. Maximum scan rates for sophisticated force mapping.
Automation
Easy and intuitive use for fast results
Advanced engineering, exceptional performance, and stability. Fully automated setup. Modern data analysis.
Cutting edge
Atomic defect resolution
Visualization of dynamic biological processes in real-time at nm resolution. Molecular dynamics and understanding complex biological systems.
Features
A new chapter in high-speed AFM: Molecular dynamics in real-time at 50 frames and true 5000 lines/second
DNA origami nanostructures containing 5 biotin binding sites on mica, imaged in fluid with streptavidin presence in closed-loop at 50 frames and 5000 lines/sec. Image Credit: Bruker JPK Instruments AG
Thanks to the capabilities of the NanoRacer, researchers now have the ability to gain a comprehensive understanding of intricate biological systems and molecular mechanisms in a way not previously possible, opening up a world of fresh and fascinating possibilities for life science applications:
- Enzyme activity monitoring
- Protein/protein interactions
- Single-molecule binding behavior
- Virus and bacteria morphology and dynamics
- Dynamics in two-dimensional protein assemblies
- Assembly and disassembly processes of protein structures
- DNA origami assembly
- Motor protein and membrane trafficking dynamics
So many things are still hidden in biological molecules. To uncover their unexplored secrets, there is a true need to directly observe individual molecules during their functional activity. The NanoRacer is the fastest commercial, high-speed AFM available, enabling their direct observation in real-time.
Toshio Ando, Professor, Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
Ando added, “A lot of innovative ideas have been incorporated for easy operation and high performance, and it is my utmost wish that many researchers will use the NanoRacer to reach their goals and make exciting discoveries.”
Image Credit: Bruker JPK Instruments AG
Outstanding resolution, renowned stability, remarkable accuracy
Atomic resolution of calcite crystal step edge, imaged in fluid, 3D topography 15 × 9 nm² [1], zoom 4 × 4 nm² [2]. Image Credit: Bruker JPK Instruments AG
Atomic defect imaging and sub-molecular resolution are now routine. The NanoRacer has the lowest noise levels of any commercially available AFM system, thanks to its high-precision electronics and improved accuracy positioning sensors in each axis.
The NanoRacer showcases the innovative of Bruker’s BioAFM team in fusing modern technology with well-proven stability, sensitivity, and usability.
- Infrared laser photothermal excitation option for clean cantilever drive, easy setup and minimized perturbance of delicate samples
- Minimized force drift for long-term experiments
- Closed-loop scanning on all axes with minimal noise levels for maximum accuracy
- Highest bandwidth digital electronics, with the lowest noise, for maximum performance
- Advanced algorithms for scanner control and feedback
- Small cantilevers and lowest forces for minimum sample damage
- Cutting-edge, high-speed power amplifier for perfect scanner drive
Individual DNA molecules imaged in fluid on mica+PLO in closed loop. Sequences [4] + [5] are imaged at 50 frames/sec. Image Credit: Bruker JPK Instruments AG
Discover a new user experience - A complete system designed for convenience
Image Credit: Bruker JPK Instruments AG
- Transportable sample carrier for simple benchtop sample preparation
- Due to the closed-loop scanner design, there is no need for calibration
- Fluid exchange via direct injection
- Easy sample and probe loading
- Newly designed 3-port liquid cell for photothermal excitation
- Simple navigation with a built-in camera for locating interesting areas on the sample
- Probe exchange in a few minutes
The NanoRacer ushers in a new era of high-speed AFM and puts laborious, complicated procedures in the past. The resultant robust and reliable design, along with a variety of new features, was created with the user in mind and makes the NanoRacer simple to use, even for those new to AFM.
From sample preparation to fully motorized and automatic optical alignment, every component is built for easy handling. Easy data collection and quick results are made possible by simplified handling. For active single-molecule samples to produce dynamic results, a quick time-to-data is essential.
Seamless handling for preparation and imaging with the transportable sample scanner. Prepare the sample conveniently on the bench and load into the NanoRacer to image. Image Credit: Bruker JPK Instruments AG
- Automated photothermal laser alignment option
- Automated calibration of cantilever spring constant
- Automated cantilever alignment
- Internal camera with autofocus
- Optimized drift compensation
Key features
- Newly created high-speed head and scanner unit
- Cutting-edge electronics
- Optimized for small and medium-sized cantilevers
- Intuitive V7 software for proven ease-of-use
- Maximum stability with a sturdy concentric design
- Optional with Bruker’s exclusive PeakForce Tapping
- Highest imaging speed of 50 frames and true 5000 lines/second with outstanding resolution
- Automated cantilever alignment
Image Credit: Bruker JPK Instruments AG