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Northwestern Medicine investigators to lead clinical trial for people with rare cancers

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

A novel national trial for people with no established alternative to treat their rare cancers is being co-led by Northwestern Medicine investigators, who helped conceive of and develop the project. [More]
New drug delivery system by Renishaw hopes to aid Parkinson’s treatment

New drug delivery system by Renishaw hopes to aid Parkinson’s treatment

Renishaw’s novel drug delivery system, to be used in partnership with Herantis Pharma Plc’s drug candidate CDNF for the treatment of Parkinson’s disease, is about to enter phase 1-2 clinical trials. The study will be supported by a €6 million grant from Horizon 2020, the European Union’s Framework Programme for Research and Innovation. [More]
Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

Ardelyx, Inc., a clinical-stage company focused on enhancing the treatment of patients with gastrointestinal and cardiorenal diseases, today announced the initiation of a Phase 3 clinical trial and an onset-of-action clinical trial evaluating RDX7675 in patients with hyperkalemia, a potentially life-threatening condition common in patients with cardiorenal disease. [More]
Phase I study of selumetinib drug shows partial response in pediatric neural tumors

Phase I study of selumetinib drug shows partial response in pediatric neural tumors

In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage. [More]
FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

Vanderbilt University scientists have received notification from the U.S. Food and Drug Administration that testing in humans may proceed for an investigational new drug for Alzheimer's disease after more than 10 years of research by scientists at Vanderbilt University and Vanderbilt University Medical Center. [More]
New study shows efficacy of Ebola vaccine in offering protection against disease

New study shows efficacy of Ebola vaccine in offering protection against disease

An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to a new study that included researchers from the University of Maryland School of Medicine. [More]
UF researchers play integral role in Ebola vaccine trial

UF researchers play integral role in Ebola vaccine trial

An international group of researchers associated with the World Health Organization has published its final report on the Ebola vaccine trial in Guinea, finding that the vaccine is a safe and effective way to prevent Ebola infection. [More]
Experimental Ebola vaccine offers high protection against deadly virus, reveals major trial

Experimental Ebola vaccine offers high protection against deadly virus, reveals major trial

An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year. [More]
First large-scale clinical study of long-acting injectable HIV drug begins

First large-scale clinical study of long-acting injectable HIV drug begins

The first large-scale clinical trial of a long-acting injectable drug for HIV prevention began today. [More]
Landmark clinical trial to test third investigational drug for Alzheimer's disease

Landmark clinical trial to test third investigational drug for Alzheimer's disease

An international team led by Washington University School of Medicine in St. Louis has selected a third investigational drug to be tested in a worldwide clinical trial - already underway - aimed at finding treatments to prevent Alzheimer's disease. [More]
NIH-supported first HIV vaccine efficacy study begins in South Africa

NIH-supported first HIV vaccine efficacy study begins in South Africa

The first HIV vaccine efficacy study to launch anywhere in seven years is now testing whether an experimental vaccine regimen safely prevents HIV infection among South African adults. [More]
Drug combination therapy delays progression of advanced breast cancer without side effects, study shows

Drug combination therapy delays progression of advanced breast cancer without side effects, study shows

Building on earlier clinical trials, UCLA researchers have confirmed that the "breakthrough" drug palbociclib when used in combination with the traditional hormonal therapy letrozole delays progression of advanced breast cancer significantly and without the harsh side effects seen in some women prescribed letrozole alone. [More]
NYU Langone-led study to examine longer-term use of suppressive antiviral medication to reduce shingles

NYU Langone-led study to examine longer-term use of suppressive antiviral medication to reduce shingles

NYU Langone Medical Center will lead a five-year, 60-center clinical trial to evaluate new treatment protocols for herpes zoster ophthalmicus (HZO), a form of shingles that can seriously and permanently affect the eye. [More]
Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Amgen and Allergan plc. today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ABP 215, a biosimilar candidate to Avastin (bevacizumab). [More]
Clinical study to test safety and ability of investigational Zika vaccine candidate begins

Clinical study to test safety and ability of investigational Zika vaccine candidate begins

The first of five early stage clinical trials to test the safety and ability of an investigational Zika vaccine candidate called the Zika Purified Inactivated Virus (ZPIV) vaccine to generate an immune system response has begun at the Walter Reed Army Institute of Research Clinical Trial Center in Silver Spring, Maryland. [More]
Sanford opens new immunotherapy study on colorectal cancer

Sanford opens new immunotherapy study on colorectal cancer

Sanford Health has opened another clinical trial exploring the power of the body's immune system to fight cancer. [More]
New clinical study to examine novel dietary approach for TNBC

New clinical study to examine novel dietary approach for TNBC

A new clinical trial for women with clinically aggressive triple-negative breast cancer (TNBC) will test a novel theory: Will a diet low in an essential nutrient make TNBC cells more vulnerable to cell killing by a new cancer drug? [More]
BetterYou’s oral spray effective in correcting vitamin D insufficiency in athletes, study shows

BetterYou’s oral spray effective in correcting vitamin D insufficiency in athletes, study shows

The findings of a study by Ulster University in conjunction with health pioneers BetterYou, have confirmed existing literature showing how athletes, despite spending an above average amount of time outdoors, are still at risk of vitamin D deficiency. [More]
Natural compound found in red wine can lower testosterone levels in women with PCOS

Natural compound found in red wine can lower testosterone levels in women with PCOS

Resveratrol—a natural compound found in red wine and grapes—can help address a hormone imbalance in women with polycystic ovary syndrome (PCOS), a leading cause of infertility in women, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. [More]
Study to investigate clinical impact of new treatment for HFrEF patients

Study to investigate clinical impact of new treatment for HFrEF patients

The academic partners in the VerICiguaT GlObal Study in Subjects with Heart Failure with Reduced EjectIon FrAction are pleased to announce that patient enrollment has begun. [More]
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