Genomics

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New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

Medullary cystic kidney disease type 1 (MCKD1) is a rare genetic kidney disease. Despite this, because it is an autosomal dominant disease, once the mutation is in a family, many family members are affected. Current diagnostic methods discover the disease late in its development.

14 Jun 2017

Study identifies new susceptibility loci for lung cancer

Using the OncoArray genotyping platform developed by multiple cancer consortia, a recent large aggregated genomewide association study identifies new susceptibility loci for lung cancer, the leading cause of cancer mortality worldwide.

14 Jun 2017

Research shows how morphological changes in the brain help shape the human connectome

Exactly when and where individual neurons develop is as important to our understanding of brain diseases as the underlying genetics, experts have shown.

14 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Impairment of a particular gene raises increases susceptibility to opioid addiction liability as well as vulnerability to binge eating according to a new study.

13 Jun 2017

Study uncovers new genetic markers linked to testicular germ cell tumors

Testicular cancer is relatively rare with only 8,850 cases expected this year in the United States. A majority of testicular cancer, 95 percent of all cases, begins in testicular germ cells, which are the cells responsible for producing sperm.

13 Jun 2017

Poor diet may fuel Alzheimer's in people who carry disease-related gene

A diet high in cholesterol, fat and sugar may influence the development of Alzheimer's disease in people who carry the ApoE4 gene, a leading risk factor for the memory-erasing disease, indicates a new USC study.

13 Jun 2017

Study finds that e-cigarettes are potentially as harmful as tobacco cigarettes in damaging DNA

A study by chemists at the University of Connecticut (UConn) offers new evidence that e-cigarettes loaded with a nicotine-based liquid are potentially as harmful as unfiltered cigarettes when it comes to causing DNA damage.

13 Jun 2017

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Scientists have known for decades that smoking cigarettes causes DNA damage, which leads to lung cancer. Now, for the first time, UNC School of Medicine scientists created a method for effectively mapping that DNA damage at high resolution across the genome.

13 Jun 2017

Genetic testing getting better at identifying testicular cancer risk

Testing for a new group of genes associated with testicular cancer has improved the ability to identify men at greatest risk of the disease, say researchers. Scientists at The Institute of Cancer Research, London, found that by testing for 19 new genetic factors in addition to the 25 risk genes already known, they could identify the 1% of men at highest risk.

13 Jun 2017

Developing synthetic mediums for growing organoids

Organoids are bits of tissue grown in vitro, in a near-physiological 3D setting. The particularity consists in the fact that organoids retain features of the patient they are derived from, even when cultured outside of the human body. This is very different from what traditional, conventional cell culture has been able to do over the past 50 years or so.

13 Jun 2017

Dietary practices get reflected in the genes of Europeans, study reveals

A recently published Cornell University study describes how shifts in the diets of Europeans after the introduction of farming 10,000 years ago led to genetic adaptations that favored the dietary trends of the time.

13 Jun 2017

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

An analysis of data from five major studies of testicular cancer has identified new genetic locations that could be susceptible to inherited testicular germ cell tumors.

12 Jun 2017

Researchers uncover seven risk genes for insomnia

An international team of researchers has found, for the first time, seven risk genes for insomnia. With this finding the researchers have taken an important step towards the unraveling of the biological mechanisms that cause insomnia.

12 Jun 2017

Anorexia nervosa linked to genetic anomalies on chromosome 12

A large-scale, international whole-genome analysis has now revealed for the first time that anorexia nervosa is associated with genetic anomalies on chromosome 12.

12 Jun 2017

KAUST-led researchers reveal epigenetic mechanism for gene regulation

An epigenetic mechanism regulating gene activity has been revealed by a KAUST-led international team of researchers investigating interactions between the human genome and its environment in adult tissues.

12 Jun 2017

UM SOM scientists identify mutated gene that may be key player in heart disease

Heart disease kills more than 600,000 Americans every year, which translates to more than one in every four deaths. Although lifestyle choices contribute to the disease, genetics play a major role.

7 Jun 2017

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Scientists at Karolinska Institutet in Sweden report that cancer cells and normal cells use different 'gene switches' in order to regulate the expression of genes that control growth.

6 Jun 2017

Stowers scientists provide evidence of cross-talk between Nanog and Hox genes

Competing regulatory genes "talk" to each other to maintain balance of cell state, according to new research from the Stowers Institute for Medical Research.

6 Jun 2017

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Rotifers are tough, microscopic organisms highly resistant to radiation and repeated cycles of dehydration and rehydration.

6 Jun 2017

Genomics

New mutation in MUC1 gene could be valuable biomarker for diagnosing kidney disease

Study identifies new susceptibility loci for lung cancer

Research shows how morphological changes in the brain help shape the human connectome

UNC study uncovers crucial function of key enzyme found in virtually all organisms

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Study uncovers new genetic markers linked to testicular germ cell tumors

Poor diet may fuel Alzheimer's in people who carry disease-related gene

Study finds that e-cigarettes are potentially as harmful as tobacco cigarettes in damaging DNA

Scientists create method for mapping genome-wide DNA damage caused by chemical carcinogen

Genetic testing getting better at identifying testicular cancer risk

Developing synthetic mediums for growing organoids

Dietary practices get reflected in the genes of Europeans, study reveals

Penn analysis finds genetic factors that could help identify men at increased risk for testicular cancer

Researchers uncover seven risk genes for insomnia

Anorexia nervosa linked to genetic anomalies on chromosome 12

KAUST-led researchers reveal epigenetic mechanism for gene regulation

UM SOM scientists identify mutated gene that may be key player in heart disease

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Stowers scientists provide evidence of cross-talk between Nanog and Hox genes

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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