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News Medical's "Thought Leaders" series is a selection of articles written by national and international experts and trusted advisers in health and medicine. All the articles are written by experts who have been invited as recognised leaders in their fields to provide a "state of the art" contribution.
Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Appetite, as a word, come from the Latin appetitus, meaning "desire for.” Therefore, appetite can be defined as a pleasurable sensation or the desire to eat. This sensation is coordinated by several brain areas associated with reward processing such amygdala, hippocampus, ventral pallidum, nucleus accumbens and striatum, and others. [More]
Unseen health risks of aortic stenosis: an interview with Dr Shelley Rahman Haley

Unseen health risks of aortic stenosis: an interview with Dr Shelley Rahman Haley

Aortic stenosis means narrowing of the aortic valve, which is the out flow valve from the left ventricle, the pumping chamber of the heart. This is the valve which opens to allow blood to flood out of the heart and all-round the body. [More]
Zika protection whilst traveling: an interview with Dr Crystal Aguh

Zika protection whilst traveling: an interview with Dr Crystal Aguh

The majority of the countries that are affected by the Zika virus are in the Caribbean. Many of the Caribbean Islands, including large islands such as Jamaica, Dominican Republic, Barbados and US Virgin Islands, as well as Mexico and other countries in Central and South America are affected. [More]
How can we defeat drug resistance? An interview with Dr Grania Brigden

How can we defeat drug resistance? An interview with Dr Grania Brigden

The O’Neill report is a wide ranging report recognising anti-microbial resistance (AMR) as a global problem with major public health and economic significance. [More]
Using spectral imaging to study brain tumors in 3D: an interview Dr Cyril Petibois

Using spectral imaging to study brain tumors in 3D: an interview Dr Cyril Petibois

I’m a biophysicist at the University of Bordeaux and I mainly work on bio-imaging methods in the cancer laboratory research facility, mostly for brain cancers. [More]
Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome. [More]
NMR-based metabolomics: an interview with Prof. Claudio Luchinat

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

We started from theoretical inorganic to bioinorganic chemistry, so looking at metals in proteins, enzymes and so on. About 30% of all the proteins that we have are metalloproteins, so it’s a huge contribution that inorganic chemistry is providing for life. [More]
Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Otosclerosis is a common cause of hearing loss, particularly amongst young adults. It normally starts in their 20s or 30s and it affects about 1 in 200 hundred people. In the UK, about 300,000 people are affected by the condition. [More]
Cryptococcus research: an interview with Associate Professor Kirsten Nielsen

Cryptococcus research: an interview with Associate Professor Kirsten Nielsen

Cryptococcus is a fungus found in the environment throughout the world that is able to cause disease in humans. While most fungal pathogens don’t receive as much press as their bacterial or viral counterparts, they can be just as deadly. [More]
Could whole-mount scanning of breast tissue lead to better clinical outcomes? An interview with Dr Martin Yaffe

Could whole-mount scanning of breast tissue lead to better clinical outcomes? An interview with Dr Martin Yaffe

We actually normally refer to this as whole-specimen imaging of breast tissue. What we mean is that when tissue is removed from the breast, which could be in the form of a lumpectomy – a breast-conserving surgery – or a mastectomy, the piece of tissue removed is relatively large. [More]
Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

The most recent complete data for England (2014/15) shows an average uptake of the guaiac Faecal Occult Blood Tests (gFOBT) from those invited by the NHS Bowel Cancer Screening Programme (BCSP) of 58.22%. [More]
Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

The hygiene hypothesis refers to the idea that decreased exposure to certain infectious agents (because of better hygiene) is the reason why we have seen an increase in inflammatory diseases in the developed world. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

We wanted to see whether supplementing the diet of disadvantaged adolescents with the omega 3 polyunsaturated acids, EPA & DHA, vitamins and minerals over a school term might improve their antisocial behaviour, which usually gets worse during a term. [More]
Digital health: putting patients at the center. An interview with Roz Davies

Digital health: putting patients at the center. An interview with Roz Davies

In England alone the NHS sees 1 million patients every 36 hours and there are 3 million volunteers across health and social care many of whom are motivated by their personal experience of healthcare services. [More]
Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

We control their electrical activity. Cardiac cells are capable of producing and transmitting electric signals through changes in a cell membrane potential. [More]
Finding treatments for rare diseases: an interview with Dr Richard Thompson

Finding treatments for rare diseases: an interview with Dr Richard Thompson

It is estimated that around 400 rare diseases have licenced treatments, and a large proportion of these are a consequence of orphan drug legislation, which has helped to incentivise the production of drugs for small patient populations. [More]
Liposuction to manage lymphedema? An interview with Professor John Boyages

Liposuction to manage lymphedema? An interview with Professor John Boyages

Lymphedema is persistent swelling of the arm and/or hand following biopsy or treatment of the axillary lymph nodes for patients with breast cancer. It is due to excess accumulation of protein‐rich fluid in body tissues. [More]
Advances in telemedicine: an interview with Dr Ameet Bakhai

Advances in telemedicine: an interview with Dr Ameet Bakhai

Telemedicine is the art of improving patient care via managing data remotely, and in this spirit one of the earliest examples often not considered in this category, would be the permanent pacemaker, first implanted into a human being in 1958. [More]
Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Cardiac troponin is a highly sensitive and specific biomarker for myocardial injury but concentrations in the blood rise over several hours after the onset of an acute myocardial infarction. [More]
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