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News Medical's "Thought Leaders" series is a selection of articles written by national and international experts and trusted advisers in health and medicine. All the articles are written by experts who have been invited as recognised leaders in their fields to provide a "state of the art" contribution.
NMR-based metabolomics: an interview with Prof. Claudio Luchinat

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

We started from theoretical inorganic to bioinorganic chemistry, so looking at metals in proteins, enzymes and so on. About 30% of all the proteins that we have are metalloproteins, so it’s a huge contribution that inorganic chemistry is providing for life. [More]
Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Otosclerosis is a common cause of hearing loss, particularly amongst young adults. It normally starts in their 20s or 30s and it affects about 1 in 200 hundred people. In the UK, about 300,000 people are affected by the condition. [More]
Cryptococcus research: an interview with Associate Professor Kirsten Nielsen

Cryptococcus research: an interview with Associate Professor Kirsten Nielsen

Cryptococcus is a fungus found in the environment throughout the world that is able to cause disease in humans. While most fungal pathogens don’t receive as much press as their bacterial or viral counterparts, they can be just as deadly. [More]
Could whole-mount scanning of breast tissue lead to better clinical outcomes? An interview with Dr Martin Yaffe

Could whole-mount scanning of breast tissue lead to better clinical outcomes? An interview with Dr Martin Yaffe

We actually normally refer to this as whole-specimen imaging of breast tissue. What we mean is that when tissue is removed from the breast, which could be in the form of a lumpectomy – a breast-conserving surgery – or a mastectomy, the piece of tissue removed is relatively large. [More]
Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

The most recent complete data for England (2014/15) shows an average uptake of the guaiac Faecal Occult Blood Tests (gFOBT) from those invited by the NHS Bowel Cancer Screening Programme (BCSP) of 58.22%. [More]
Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

The hygiene hypothesis refers to the idea that decreased exposure to certain infectious agents (because of better hygiene) is the reason why we have seen an increase in inflammatory diseases in the developed world. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

Could oral supplements affect teenage behavior? An interview with Prof. Stein and Dr Tammam

We wanted to see whether supplementing the diet of disadvantaged adolescents with the omega 3 polyunsaturated acids, EPA & DHA, vitamins and minerals over a school term might improve their antisocial behaviour, which usually gets worse during a term. [More]
Digital health: putting patients at the center. An interview with Roz Davies

Digital health: putting patients at the center. An interview with Roz Davies

In England alone the NHS sees 1 million patients every 36 hours and there are 3 million volunteers across health and social care many of whom are motivated by their personal experience of healthcare services. [More]
Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

We control their electrical activity. Cardiac cells are capable of producing and transmitting electric signals through changes in a cell membrane potential. [More]
Finding treatments for rare diseases: an interview with Dr Richard Thompson

Finding treatments for rare diseases: an interview with Dr Richard Thompson

It is estimated that around 400 rare diseases have licenced treatments, and a large proportion of these are a consequence of orphan drug legislation, which has helped to incentivise the production of drugs for small patient populations. [More]
Liposuction to manage lymphedema? An interview with Professor John Boyages

Liposuction to manage lymphedema? An interview with Professor John Boyages

Lymphedema is persistent swelling of the arm and/or hand following biopsy or treatment of the axillary lymph nodes for patients with breast cancer. It is due to excess accumulation of protein‐rich fluid in body tissues. [More]
Advances in telemedicine: an interview with Dr Ameet Bakhai

Advances in telemedicine: an interview with Dr Ameet Bakhai

Telemedicine is the art of improving patient care via managing data remotely, and in this spirit one of the earliest examples often not considered in this category, would be the permanent pacemaker, first implanted into a human being in 1958. [More]
Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Diagnosing heart attacks in 1 hour: an interview with Dr Richard Body

Cardiac troponin is a highly sensitive and specific biomarker for myocardial injury but concentrations in the blood rise over several hours after the onset of an acute myocardial infarction. [More]
Innovations in pre-clinical MRI: an interview with Priv. Doz. Dr. Dominik von Elverfeldt

Innovations in pre-clinical MRI: an interview with Priv. Doz. Dr. Dominik von Elverfeldt

To me the most exciting aspect of pre-clinical imaging is its broad range, from very basic science up to applied science. You deal with a range of disciplines including biology, chemistry, physics, biochemistry, biophysics, cell biology and of course medicine, as the aim is the translation of research to humans. [More]
Using proteomics to understand Alzheimer’s: an interview with Dr Renã Robinson

Using proteomics to understand Alzheimer’s: an interview with Dr Renã Robinson

In our bioanalytical mass spectrometry lab we use proteomics techniques to try to understand more about Alzheimer's disease. The primary thrust of our research is that we're interested in understanding the changes that take place outside of the brain and how those correlate with what's taking place inside the brain [More]
Home screening for bowel cancer: an interview with Deborah Alsina, Chief Executive of Bowel Cancer UK

Home screening for bowel cancer: an interview with Deborah Alsina, Chief Executive of Bowel Cancer UK

FIT (faecal immunochemical test) is a screening test for bowel cancer which detects hidden traces of blood in stools. It is now used in population screening around the world including Italy, The Netherlands, France, Ireland, New Zealand, Australia, Spain, Slovenia, Malta, Japan, parts of Canada, and Southeast Asia. [More]
Tackling superbugs with antibiotic resistance breakers: an interview with Professor Colin Garner, Chief Executive, Antibiotic Research UK

Tackling superbugs with antibiotic resistance breakers: an interview with Professor Colin Garner, Chief Executive, Antibiotic Research UK

Superbugs – or to give them their correct name, antibiotic resistant bacteria – arise on repeated exposure to antibiotics. In any population of bacteria there will be a few that are antibiotic resistant (approximately 1 in 100 million bacteria). If these bacteria are allowed to grow and multiply, an antibiotic resistant infection results. [More]
Advances in NMR metabolomics: an interview with Professor Tone F. Bathen

Advances in NMR metabolomics: an interview with Professor Tone F. Bathen

The main objective of our research is to improve and individualize cancer diagnostics and cancer treatment. We try to achieve this through the integrated use of MR technology and the development of data-driven tools to analyze tumors on both a functional and molecular level. [More]
Explaining asthma to children: an interview with Gabe Ortiz MPAS, PA-C

Explaining asthma to children: an interview with Gabe Ortiz MPAS, PA-C

I think the main challenges in explaining asthma to children, is to make them understand that in most instances it may be a chronic condition that might need chronic daily medicine. [More]
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