News Medical's "Thought Leaders" series is a selection of articles written by national and international experts and trusted advisers in health and medicine. All the articles are written by experts who have been invited as recognised leaders in their fields to provide a "state of the art" contribution.
Lynch syndrome is an inherited condition which causes about 1,100 cases of bowel cancer and 1,000 other cancers annually in the UK. It is caused by a fault in the mismatch repair gene (MMR) which usually works to prevent cancer.
The first thing that is important to stress is that this is an area that we actually know very little about. What we generally think, rather than know, is that NTM has a lot in common with pulmonary tuberculosis.
IDPs are proteins that contain stretches of amino-acid sequence that are flexible and do not comprise stable structure in isolation. This is in contrast with a more traditional view of proteins as largely occupying a stable native structure that correlates with functions such as enzyme activity or binding.
The majority of patients in neonatal intensive care units are premature babies, who often have infectious (congenital pneumonia) or noninfectious (tachypnea, infant respiratory distress syndrome) respiratory pathologies.
Brain plasticity is the phenomenon by which the brain can rewire and reorganize itself in response to changing stimulus input. Brain plasticity is at play when one is learning new information (at school) or learning a new language...
Nanoparticles enter the organism in a number of ways. In most cases through inhalation and ingestion. When inhaled, the majority of them are expelled with the next breath. When ingested, most of them are gotten rid of through feces.
Contamination is thought to be a significant problem. Depending on which study you look at, the rates of urine contamination can be 17% or upwards. The standard method of midstream urine collection is for the healthcare professional...
We are a research group at the Brain and Creativity Institute at University of Southern California. In 2012, we began a five-year longitudinal study in collaboration with the Los Angeles Philharmonic and their Youth Orchestra program at the Heart of Los Angeles (YOLA at HOLA).
About eight years ago the WHO put out a call saying that we needed data that better represented real world patients. Our ambition was to create evidence earlier in the life cycle of medicine that better represented the population that would...
BA and CBT are quite fundamentally different. BA is what we call an outside-in treatment, which means it focuses on helping people with depression change the way in which they behave.
There are many studies that support a link between type 2 diabetes and risk of cancer. The relationship is complex and multifactorial.
In the past vitamin D was just thought to be important in regulating calcium homeostasis and bone health as vitamin D deficiency is best known for causing rickets in children and osteomalacia in adults.
In short, the detrimental effects of sitting for prolonged hours can be divided into acute, or short-term, and long-term effects.
My research lab studies several classes of systems. We are mostly interested in looking at large protein assemblies to understand their structure, dynamics and how their properties relate to their malfunction in disease.
The cornea is a transparent tissue lining the front of the eye, that is invisible tissue to the naked eye. It is a delicate tissue and disease or injury may lead to a loss of transparency or a change in the shape of the cornea, resulting in severe visual impairment.
Delirium is a terribly distressing syndrome of acute confusion. We often see it in the emergency department in older patients and in those with multiple medical problems. They may be acting strangely at home and concerned loved ones bring them to the emergency department.
There is a lot of evidence that Staphylococcus aureus (S. aureus) is involved in eczema. Eczema is now thought to be caused by a barrier dysfunction of the skin that allows external triggers to cause an overshoot of inflammation.
Detection of malignant skin alterations is currently aided by optical microscopes such as dermoscopes or optical microscopes. While the latter offers high resolution, it comes with a major disadvantage, just like any other purely microscopic method: it only provides a partial view of the skin due to the low penetration depth.
Jacopo Annese, President and CEO of the Institute for Brain and Society, a non-profit organization dedicated to democratizing neuroscience and making neuroscience tools and knowledge about the brain more available to the public, discusses his work on the Human Brain Library.
tDCS is the administration of week electrical currents through electrodes on the scalp to modulate brain activity.