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M-M-R II

Measles, Mumps and Rubella Virus Vaccine Live
Consumer Medicine Information

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some common questions about M-M-R II. It does not contain all the information that is known about M-M-R II. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

What M-M-R II is used for

M-M-R II is a vaccine used to help protect people from getting measles, mumps and rubella (German measles). It can be given to people 12 - 15 months of age and older.
Protection against these infections is important as they can cause serious problems in some people.
Measles is a serious disease that causes a high fever (temperature), runny nose, cough, conjunctivitis and a rash. It usually lasts for about 1 to 2 weeks. It is very easily passed from one person to another in the tiny droplets of moisture which are expelled during coughing or sneezing. One out of every 10 children who catch measles will also have an ear infection or pneumonia. On rare occasions, measles can also cause an infection of the brain that could lead to seizures, hearing loss, mental retardation, and even death. Babies and adults who catch measles are often much sicker for a longer time or are more likely to die than school children and teenagers who catch measles.
Mumps causes fever, headache, and swollen, painful glands under the jaw (salivary glands) and usually lasts several days. It is easily passed from one person to another by the tiny droplets of moisture expelled during coughing or sneezing. Mumps can sometimes be a very serious disease, causing a mild inflammation of the coverings of the brain and spinal cord (meningitis) in about one person in every 10 who catch it. About one out of every 4 teenage or adult males with mumps will have a painful swelling of the testicles for several days. This does not usually affect their ability to father children, but can cause sterility in rare cases. Teenagers and adults, especially males, who catch mumps are often much sicker and more likely to suffer longer than children do.
Rubella is usually a mild disease that causes a mild fever, swollen glands in the neck, pain and swelling in the joints, and a rash that lasts for 2 or 3 days. Rubella is very dangerous if a pregnant woman catches it. Pregnant women who catch rubella can have babies who are stillborn, or have heart disease, blindness, deafness, or problems with learning. Rubella is also spread to others in the tiny droplets of moisture expelled during coughing or sneezing.
M-M-R II contains weakened strains of living measles, mumps and rubella viruses. These strains of live viruses cause either mild or no symptoms of infection. When injected the vaccine causes the body to produce its own protection by making disease-fighting substances (antibodies) against these infections. If a vaccinated child comes into contact with measles, mumps or rubella virus, the body is usually ready, and produces antibodies to destroy the virus. However, as with all vaccines, 100% protection against measles, mumps and rubella cannot be guaranteed. Also it may take up to 4-6 weeks for maximum protection to develop, so occasionally infections may occur during this time.
The chance of a severe reaction from M-M-R II is very small, but the risks from not being vaccinated are very serious.

Before you are given M-M-R II

When you or your child must not be given it

Do not have the vaccine if you have an allergy to M-M-R II or any of the ingredients listed at the end of this leaflet, including gelatin.
Do not have M-M-R II if you have a serious allergy to:
the antibiotic neomycin
eggs - this is because the strains of measles and mumps viruses used to make M-M-R II are grown in eggs.
Symptoms of a serious allergic reaction include swelling of the face, lips, tongue, throat, difficulty in breathing, or hives.
Do not have M-M-R II if:
you have an infection with fever (high temperature)
you have active untreated tuberculosis (TB)
you are taking medicines which decrease the body's immune defence system (eg, corticosteroids, cyclosporin, cancer medicines).
This does not include taking corticosteroids (eg, cortisone, prednisone) as replacement therapy for Addison's disease.
you have diseases which decrease the body's immune defence system, such as cancers of the blood cells (eg, leukaemia, lymphoma) and AIDS
Do not have M-M-R II if you are pregnant. Also, do not become pregnant for 3 months after being given the vaccine.
Do not have M-M-R II if the expiry date on the pack has passed.
If the vaccine is used after the expiry date has passed, it may not work.
If you are not sure whether you or your child should have M-M-R II, talk to your doctor.

Before you or your child are given it

Tell your doctor if:

1. you have the following medical conditions or a family history of them:

febrile convulsions (fits or seizures due to a high temperature)
brain damage
epilepsy
low blood platelet count
HIV

2. you have recently had a blood transfusion or been given immune serum globulins

Your doctor may need to delay giving the vaccine for 3 months.

3. you are breast feeding

Your doctor will discuss the possible risks and benefits of you being given M-M-R II while breast-feeding.

4. you have allergies to any other medicines of vaccines, or any other substances, such as foods, preservatives of dyes.

If you have not told your doctor about any of the above, tell them before you or your child are given M-M-R II.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.
M-M-R II may not work as well as it should if you or your child are taking medicines that decrease the immune system, such as corticosteroids (eg. prednisone) or cyclosporin.
Your doctor will advise you if you are taking any of these or other medicines that decrease the immune system. Your doctor will decide whether or not to give the vaccine.
M-M-R II should be given one month before or after administration of other vaccines. However, other schedules have been used. Your doctor will decide the vaccination schedule.

How M-M-R II is given

How much is given

The dose for children, teenagers and adults is 0.5 mL.

How it is given

M-M-R II is usually injected just under the skin (subcutaneously) of the upper arm by a doctor or trained nurse.
The vaccine should not be injected directly into blood vessels (intravascularly).

Vaccination schedule

M-M-R II is usually given once to people 12-15 months of age or older. If the vaccine is given to children younger than 12 months old, a second injection should be given on or after 15 months of age.
Keep a record of your child's vaccinations and update this after each injection.
Keep your child's follow-up appointment with your doctor or clinic.
It is important for your child to have the follow-up dose of M-M-R II, if indicated, at the appropriate time to make sure the vaccine has the best chance of providing protection against measles, mumps and rubella.

If you miss a dose

If you miss a scheduled dose, talk to your doctor and arrange another visit as soon as possible.

Side Effects

Tell your doctor or pharmacist as soon as possible if you or your child does not feel well during or after having had an injection of M-M-R II.
M-M-R II helps protect most people from measles, mumps and rubella, but it may have unwanted side effects in a few people. All medicines and vaccines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you or your child have any of the following and they are troublesome or ongoing:
mild burning and/or stinging at the injection site
local reaction around the injection site such as soreness, redness, swelling, or a hard lump
fever, feeling unwell, sore throat, cough, runny or blocked nose
dizziness, headache
feeling sick (nausea), vomiting, diarrhoea
unsteadiness when walking
irritability
limited rash
swelling of the glands in the neck
swelling of the salivary glands (in front of the ear and/or under the back of the jaw)
unusual bleeding or bruising under the skin, and swelling of the testicles
swelling of the epididymis, a part of the male reproductive system
itchiness of the skin
Transient joint pain and/or swelling
These are the more common side effects of M-M-R II. For the most part these have been mild. They usually improve or disappear within a few days.
Tell your doctor immediately if you notice any of the following:
rash all over the body
aches or pains in joints, arthritis
bruising or purple spots on the skin
swelling of the lungs causing coughing, difficulty breathing and wheezing with or without fever, chills, shortness of breath, cough, phlegm and occasionally blood
These are serious side effects. You may need urgent medical attention. Serious side effects are rare.
Tell your doctor immediately or go to accident and emergency at your nearest hospital if you or your child get any of the following:
a seizure or convulsion, which may or may not be accompanied by a very high fever
headache and fever, progressing to hallucinations, confusion, stiff neck and sensitivity to light
pain, numbness, or tingling of the hands, arms, legs or feet
fainting
severe blisters with bleeding in the lips, eyes, mouth, nose or genitals
These are serious side effects. You may need urgent medical attention. Serious side effects are rare.
Other side effects may also occur rarely and some of these may be serious. These include allergic reactions, seizures, and inflammation of the nervous system (brain and/or spinal cord).

Allergic Reaction:

As with all vaccines given by injection, there is a very small risk of a serious allergic reaction.
Tell your doctor immediately or go to accident and emergency if you notice any of the following:
wheezing or shortness of breath
swelling of the face, lips, mouth, throat or neck which may cause difficulty in swallowing or breathing
swelling of the hands, feet, or ankles
pinkish, itchy swellings on the skin, also called hives or nettlerash
skin rash, itchiness
If you have these, you may have had a serious allergic reaction to M-M-R II. You may need urgent medical attention or hospitalisation. Most of these side effects occur within 15-30 minutes of vaccination, before you or your child leave the doctor's surgery or clinic.
Other side effects not listed above may also occur in some people. Tell your doctor if you notice any other effects.
Tell your doctor promptly about any of these or any other unusual symptoms. If the condition persists or worsens, seek medical attention.
Do not be alarmed by this list of possible side effects. You or your child may not experience any of them.

Storage

M-M-R II is usually stored in the doctor's surgery or clinic, or at the pharmacy. However if you need to store M-M-R II:
Keep it where children cannot reach it.
Keep it in the refrigerator at a temperature between 2°C and 8°C, but not in the door compartment. Do not freeze it.
Protect the injection from light by keeping it in the original pack until it is time for it to be given.

Product description

What it looks like

M-M-R II comes as white powder in glass vials. It is reconstituted with a special diluent to make a solution suitable for injection.

Ingredients

The active ingredients of M-M-R II are weakened strains of measles, mumps and rubella (German measles) viruses.
Inactive ingredients:
neomycin
sorbitol
hydrolysed porcine gelatin
sodium phosphate
sucrose
sodium chloride
recombinant human albumin
foetal bovine serum
other buffer and media ingredients
The manufacture of this product includes exposure to bovine derived materials. No evidence exists that any case of vCJD (considered to be the human form of bovine spongiform encephalopathy) has resulted from the administration of any vaccine product.

Supplier

M-M-R II is supplied in Australia by:
bioCSL Pty Ltd
63 Poplar Road
PARKVILLE VIC 3052
This leaflet was prepared in December 2015.
Australian Register Numbers:
AUST R 118449
AUST R 118451
AUST R 201877