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COVID-19 susceptibility mechanism discovered using a newly created tool

Researchers have discovered a mechanism for COVID-19 susceptibility using a newly created tool. The tool, GASPACHO, captures dynamic changes in gene expression along the innate immune response, allowing researchers to identify genes and molecular pathways associated with disease risk that have previously been too complex to detect or interpret.

15 Jun 2023

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Science China Life Sciences magazine recently reported on the research results of Tang Beisha's team from Xiangya Hospital of Central South University, Liu Jing Yu's team from the Institute of Neurology of the Chinese Academy of Sciences, and Zhang Luoying's team from Huazhong University of Science and Technology, including Du Shiyue, Zeng Sheng, and Song Li. Epilepsy has a complex etiology with 80% owing a genetic basis.

15 Jun 2023

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

In a new study, published today (15 June) in Nature Communications, a multi-centre team led by the Wellcome Sanger Institute, the University of Oslo, Imperial College London and UCL, has mapped for the first time the evolutionary timeline and population distribution of Escherichia coli’s protective outer capsule, which is responsible for the bacterium’s virulence.

15 Jun 2023

Silver-doped glass fibers used as a potential treatment for wound healing, finds study

Researchers at the University of Birmingham have demonstrated that silver retains antimicrobial activity for longer when it is impregnated into 'bioactive glass', and shown for the first time how this promising combination delivers more long-lasting antimicrobial wound protection than conventional alternatives.

15 Jun 2023

Cerillo showcases wireless, scalable, off-the-shelf co-culture solution

Cerillo, a biotechnology company at the forefront of developing advanced research platforms for the study of the microbiome, will host demonstrations of the company’s new co-culture duet system at ASM Microbe 2023 from June 16-18th in Houston, Texas at booth #704.

From Cerillo 15 Jun 2023

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia.

15 Jun 2023

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

People with weakened immune systems are at constant risk of infection. Pseudomonas aeruginosa, a common environmental bacterium, can colonize different body parts, such as the lungs, leading to persistent, chronic infections that can last a lifetime – a common occurrence in people with cystic fibrosis.

14 Jun 2023

Breast cancer drug development work moves forward with support from STTR grant

Triple negative breast cancer is an aggressive subtype of breast cancer with worse survival outcomes than most.

14 Jun 2023

Synthetic compound used in perfumes shows potential to stop coagulopathy during a massive hemorrhage

The chances of surviving massive blood loss from a traumatic injury such as a gunshot wound are around 50 percent. To survive, a patient needs two things to happen quickly: a large infusion of blood and coagulation at the wound to stop the bleeding.

14 Jun 2023

CrossDome tool helps predict the potential risks of T-cell immunotherapy

Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells.

14 Jun 2023

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Crossing the membrane is a major challenge on the journey through the cell. Large biomolecules usually benefit from different transport strategies to overcome the lipid bilayer, so the design and synthesis of new carriers is key for the delivery of hydrophilic substances, such as pharmaceuticals, into the cell.

14 Jun 2023

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Neuroscientists have long searched for ways to reopen "critical periods" in the brain, when mammals are more sensitive to signals from their surroundings that can influence periods of brain development.

14 Jun 2023

Researchers create a diagnostic test to identify functional sperm in infertile men

In a recent study, researchers created a diagnostic test to identify functional sperm in infertile men that could change the treatment of male infertility and assisted reproductive technology.

14 Jun 2023

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

University of Queensland researchers have used an algorithm from a video game to gain insights into the behavior of molecules within live brain cells.

14 Jun 2023

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

Surf's up, sharks down: Study finds low shark bite risk despite overlapping human-shark activity in Southern California

In a study published in the journal PLOS ONE, scientists have determined the spatio-temporal habit overlap between juvenile white sharks and humans across the entire southern California coastline.

13 Jun 2023

Scientists show how pregnancy induces progressive changes in the maternal immune system

We have a good understanding of how a woman's external features can change during pregnancy, but scientists know surprisingly little about what biological changes occur internally.

13 Jun 2023

Molecule found in the venomous toadfish controls lung inflammation in mice

A molecule found in the venomous toadfish Thalassophryne nattereri has proved capable of controlling lung inflammation and could be the basis for a more effective asthma drug.

13 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

13 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Life Science News

COVID-19 susceptibility mechanism discovered using a newly created tool

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

Silver-doped glass fibers used as a potential treatment for wound healing, finds study

Cerillo showcases wireless, scalable, off-the-shelf co-culture solution

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

Breast cancer drug development work moves forward with support from STTR grant

Synthetic compound used in perfumes shows potential to stop coagulopathy during a massive hemorrhage

CrossDome tool helps predict the potential risks of T-cell immunotherapy

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Researchers create a diagnostic test to identify functional sperm in infertile men

Algorithm from a video game provides insights into the behavior of molecules within live brain cells

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Surf's up, sharks down: Study finds low shark bite risk despite overlapping human-shark activity in Southern California

Scientists show how pregnancy induces progressive changes in the maternal immune system

Molecule found in the venomous toadfish controls lung inflammation in mice

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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