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GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

A new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis."

23 May 2023

Contraception ends same-sex sexual behavior’s genetic maintenance in modern societies

Evolution depends on genes being passed down through the generations via reproduction, and same-sex sexual behavior does not result in offspring.

23 May 2023

39th Barcelona BioMed Conference focuses on latest advances in proximity induction-based pharmacology

Targeted protein degradation uses different types of "degrading" drugs (degraders) to force proximity between a target protein (for example, a mutated protein that contributes to the development of a disease) and the cellular machinery that directs protein degradation.

23 May 2023

Cytoelectric Coupling hypothesis: Fluctuating electric fields shape the brain’s molecular infrastructure

To produce its many functions, including thought, the brain works at many scales. Information such as goals or images is represented by coordinated electrical activity among networks of neurons, while within and around each neuron a mix of proteins and other chemicals physically carries out the mechanics of participating in the network.

22 May 2023

Newly developed method can help identify the special differences in genetic information

Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests.

22 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

22 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Understanding the cause for suboptimal germinal center response in aged mice

Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk.

22 May 2023

Dad’s genome may be playing a bigger role in siblings born with ASD

Cold Spring Harbor Laboratory researchers have flipped the script on autism spectrum disorder (ASD) genetics.

22 May 2023

Honokiol inhibits replication of SARS-CoV-2 in several cell types

A compound called honokiol, which is found in the bark of multiple species of magnolia tree, inhibits replication of SARS-CoV-2 virus in several types of cells, according to a team of researchers in the Netherlands.

22 May 2023

AI-based method predicts small molecule substrates of enzymes

Enzymes are the molecule factories in biological cells. However, which basic molecular building blocks they use to assemble target molecules is often unknown and difficult to measure.

22 May 2023

Newly discovered molecule effectively destroys senescent cells

Over time, the body's cells stop working properly and begin to accumulate, which eventually leads to tissues aging.

22 May 2023

Exploring how and why nitrate has contrasting potential risks and benefits

Despite our understanding of nutrition expanding remarkably in recent times, few aspects of our diet continue to confuse and divide the experts like nitrate.

22 May 2023

New vaccine concept could lead to a new generation of vaccines against SARS-CoV-2

Researchers at the University of Basel have developed a new approach for a vaccine against COVID-19.

22 May 2023

The State of Tech Bio: Survey finds majority of biodevelopers write code and use machine learning; protein engineering is a top priority

Cradle, the platform that helps scientists to design and program proteins, today published the findings of its first BioDeveloper survey, exploring the methods and priorities of biodevelopers to build a picture of trends within the synthetic biology sector.

From Cradle Bio B.V. 22 May 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Unraveling the origins of humanity: New research challenges single-origin theory

Researchers explore the complex demographic history of Homo sapiens in Africa, revealing a reticulated population structure dating back to Marine Isotope Stage 5. The study challenges previous assumptions about archaic hominin contributions and emphasizes the significance of employing diverse models for robust inferences about ancient human history.

21 May 2023

Combining generative AI and quantum computing to accelerate drug discovery

Insilico Medicine, a clinical stage generative artificial intelligence (AI)-driven drug discovery company, today announced that it combined two rapidly developing technologies, quantum computing and generative AI, to explore lead candidate discovery in drug development and successfully demonstrated the potential advantages of quantum generative adversarial networks in generative chemistry.

19 May 2023

Genomes of modern humans shaped by admixture events

The course of human history has been marked by complex patterns of migration, isolation, and admixture, the latter a term that refers to gene flow between individuals from different populations.

19 May 2023

Life Science News

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Contraception ends same-sex sexual behavior’s genetic maintenance in modern societies

39th Barcelona BioMed Conference focuses on latest advances in proximity induction-based pharmacology

Cytoelectric Coupling hypothesis: Fluctuating electric fields shape the brain’s molecular infrastructure

Newly developed method can help identify the special differences in genetic information

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Surviving without glucose: uridine-derived ribose as an alternative energy source

Understanding the cause for suboptimal germinal center response in aged mice

Dad’s genome may be playing a bigger role in siblings born with ASD

Honokiol inhibits replication of SARS-CoV-2 in several cell types

AI-based method predicts small molecule substrates of enzymes

Newly discovered molecule effectively destroys senescent cells

Exploring how and why nitrate has contrasting potential risks and benefits

New vaccine concept could lead to a new generation of vaccines against SARS-CoV-2

The State of Tech Bio: Survey finds majority of biodevelopers write code and use machine learning; protein engineering is a top priority

Genetic insights unveil promising therapeutic targets for critical COVID-19

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Unraveling the origins of humanity: New research challenges single-origin theory

Combining generative AI and quantum computing to accelerate drug discovery

Genomes of modern humans shaped by admixture events

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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