Medical and Life Science White Papers RSS Feed - Medical and Life Science White Papers

Medical and Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in medical research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

  • Investigating a neuroprotective pentapeptide in a murine model of intracerebral hemorrhage

    Investigating a neuroprotective pentapeptide in a murine model of intracerebral hemorrhage

    Intracerebral hemorrhage (ICH) refers to bleeding around or within the brain when a blood vessel in the brain ruptures. Blood leaks into the brain causing tissue injury, which leads to stroke symptoms such as weakness, blindness, numbness in one side of the body and speech loss. [More]
  • Cannabis testing in the legalization era

    Cannabis testing in the legalization era

    Attitudes towards cannabis have shifted dramatically over the last two decades, and this has been reflected in recent changes to the law in many countries around the world. Just this November, an additional four US states voted to make recreational cannabis use legal, bringing the total to eight, (plus Washington DC). And over half of US states have legalized medicinal cannabis use. [More]
  • A Guide for Selecting Digital Microscopy Cameras for High-Quality Pathology Images

    A Guide for Selecting Digital Microscopy Cameras for High-Quality Pathology Images

    Nowadays, most pathologists use digital systems within their research projects and practices to analyze images, communicate, and store data. The use of digital systems, whether be it surgical, clinical, forensic, or other branches of pathology, has considerably improved communication and consultation among specialists and also allows for faster diagnosis for patients. [More]
  • Advantages of Next Generation Optima AUC over Proven ProteomeLab

    Advantages of Next Generation Optima AUC over Proven ProteomeLab

    Analytical ultracentrifugation (AUC) has been a powerful analytical technique in the analysis of macromolecules in solution since its introduction in the 1920s, resulting in impactful scientific discoveries1. AUC offers a matrix-free environment that enables the near-native characterization of proteins1, extracellular vesicles2, nucleic acids3, colloids4, and nanoparticles5. [More]
  • Technology Brings a New Age in Food Safety and Analysis

    Technology Brings a New Age in Food Safety and Analysis

    Protecting consumers has long been a priority for the food industry, but modern times have changed the specific challenges producers and regulators face when it comes to food safety. Increasing globalization presents new opportunities for food fraud with the potential for billion-dollar payoffs. [More]
  • Nanotechnology Advances for Cancer Diagnostics and Nanotherapy

    Nanotechnology Advances for Cancer Diagnostics and Nanotherapy

    The delivery of drugs and diagnostic markers to cancer tissues has been a major challenge in the development of cancer therapies. Typical delivery methods distribute products throughout the body, affecting healthy and cancerous cells, thereby toxic effects to healthy cells limit the scope and effectiveness of the anticancer therapy. [More]
  • Light Scattering Reveals Novel DNA Applications

    Light Scattering Reveals Novel DNA Applications

    Deoxyribonucleic acid (DNA) has a unique structure and stability, making it an amazingly versatile molecule. This molecule plays a critical role in the biological world as it encodes and passes on all inheritable genetic information to subsequent generations. [More]
  • The Seven Pitfalls of Whole Slide Scanning

    The Seven Pitfalls of Whole Slide Scanning

    The practice of pathology is entering a period of broad adoption of digital workflows, as near real-time access to “digital slides” offers opportunities to greatly improve clinical outcomes and accelerate research. As Liron Pantanowitz, Professor of Pathology and Biomedical Informatics at University of Pittsburgh Medical Center recently described, digital pathology offers benefits with respect to image analysis, education, telepathology, centralized services, archiving, workflow efficiency, subspecialty practice, and computational pathology. [More]
  • Characterizing Hydrogels for Use in Drug Delivery Systems

    Characterizing Hydrogels for Use in Drug Delivery Systems

    Drug delivery systems are technologies used to ensure the safe and effective transport of a drug around the body and its release at the desired site of action. They incorporate a range of approaches and methodologies designed to modify the drug distribution and availability in order to optimize a drug's efficacy and safety profile. [More]
  • Using Label-Free Wound Healing Assay to Monitor Cell Migration and its Inhibition

    Using Label-Free Wound Healing Assay to Monitor Cell Migration and its Inhibition

    The term cell migration refers to the arbitrary movement of cells that play an important role in pathological and physiological processes. Cell migration is also a central part of fundamental biological processes like immune response, wound healing, tissue formation, and other processes like invasion and metastasis of cancer [1,2]. [More]
  • Quantifying Apoptosis Activity Using Automated Imaging and Advanced 3D Cell Culture Techniques

    Quantifying Apoptosis Activity Using Automated Imaging and Advanced 3D Cell Culture Techniques

    Programmed cell death, known as apoptosis is necessary for homeostasis and normal development of all multicellular organisms. In fact, it is an important research tool used for fighting cancer. However, there is a challenge while culturing cell models, even those of human origin, for use in apoptosis studies. [More]
  • Culturing Neural Stem Cells into 3D Neurospheres for DNT Testing

    Culturing Neural Stem Cells into 3D Neurospheres for DNT Testing

    As the developing nervous system is very susceptible to toxicant exposure, developmental neurotoxicity (DNT) of environmental chemicals is hazardous to human health. The consequent neurological deficits may have long lasting emotional and financial impact on families and society. [More]
  • Predicting Long-term Stability of mAbs in Formulation Screenings using a Single, Fully Automated Platform

    Predicting Long-term Stability of mAbs in Formulation Screenings using a Single, Fully Automated Platform

    Biologics is part of the rapidly growing group of drugs. New, predictive analytical methods are required to streamline the development process for an ever-increasing number of complex molecules, such as biosimilars, antibody-drug conjugates (ADCs) and mAbs. The long-term stability of a drug is a significant aspect of the development process (Geng et al, 2014; Seeliger et al, 2015). [More]
  • Five Tips for Faster and Better Cell Counting

    Five Tips for Faster and Better Cell Counting

    Cell counting is a tedious process that needs to be performed properly, be it automated or manual, in academia or industry, as reliable results are required to continue the research. In order to help with this process, CytoSMART Technologies provides five important tips to get more out of cell counting. [More]
  • Comparison of μDSC and nanoDSF Methods for Thermal Stability Assessment of Biologics

    Comparison of μDSC and nanoDSF Methods for Thermal Stability Assessment of Biologics

    Thermal stability is a common method for evaluating the physical stability of proteins during formulation development. For years, this has been achieved by μDSC, which measures changes in the heat capacity (Cp) of a protein-containing solution, with respect to a reference solution. Both thermodynamic stability parameters and unfolding transition temperatures can be calculated using μDSC. [More]
  • Using PinPoint™ Mode for Surface Nanochemical Property Imaging

    Using PinPoint™ Mode for Surface Nanochemical Property Imaging

    In order to offset the positional errors between F-d and topographical data, PinPoint™ Nanomechanical mode was recently developed and implemented in the operation software, such as Park SmartScan, of modern AFM systems. [More]
  • Using Atomic Force Microscope-Based Fast Nanomechanical Mode for Imaging Collagen Fibrils in Air and Liquid Conditions

    Using Atomic Force Microscope-Based Fast Nanomechanical Mode for Imaging Collagen Fibrils in Air and Liquid Conditions

    The atomic force microscope (AFM) is a robust nanotechnology tool which is extensively used to characterize the collagen’s mechanical properties, morphology, and in-situ self-assembly processes. [More]
  • Imaging Collagen Fibrils with PinPoint™ Nanomechanical Mode

    Imaging Collagen Fibrils with PinPoint™ Nanomechanical Mode

    With PinPoint™ Nanomechanical mode, a quantifiable elasticity map that previously took days to generate can now be obtained within an hour. Additionally, the technique also provides a correlated topography image that shows the orientation and position of sample collagen nanofibers. [More]
  • Using NTA to Study Aggregation Behavior of Liposome-Protein Complexes

    Using NTA to Study Aggregation Behavior of Liposome-Protein Complexes

    Aggregation of both synthetic and biological materials is a great concern, posing problems at different stages of the discovery and formulation processes. The capability to identify and characterize aggregates is of broad utility, and the experiments discussed in this article demonstrate the ability of the nanoparticle tracking analysis (NTA) technique, that is one of a kind, to comprehend the dynamics of aggregation in a biological system through high resolution particle-by-particle analysis. [More]
  • Using Nanoparticle Tracking Analysis for the Characterization of Gold-Labeled Adeno-Associated Virus

    Using Nanoparticle Tracking Analysis for the Characterization of Gold-Labeled Adeno-Associated Virus

    This article shows how a combination of nanoparticle tracking analysis (NTA) technique and a gold labeling method can be used to rapidly measure the concentration and size of Adeno-Associated Virus (AAV). [More]
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