Medical and Life Science White Papers RSS Feed - Medical and Life Science White Papers

Medical and Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in medical research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

  • A Review on Beneficial Role of High Density Lipoproteins in Cardiovascular Health

    A Review on Beneficial Role of High Density Lipoproteins in Cardiovascular Health

    High density lipoproteins (HDLs) play key role in the removal of excess lipids and fatty acids through the reverse cholesterol transport (RCT) pathway. In addition, HDL proteins give protection against cardiovascular disease, thanks to their anti-oxidant and anti-inflammatory activities. The beneficial health profile of HDL also has clinical relevance. How HDLs help maintain cardiovascular health is discussed in this article. [More]
  • Evaluation of Mixing Performance of Vitl Co-Mix Laboratory Mixer with High Viscosity Solutions

    Evaluation of Mixing Performance of Vitl Co-Mix Laboratory Mixer with High Viscosity Solutions

    An orbital mixer’s efficiency is significantly affected by the viscosity of a solution. Commonly used non-aqueous mixing solvents for dyes, vaccines, and drugs are viscous liquids such as glycerol and polyethylene-glycol (PEG). These liquids are also used in protein solutions as stabilizing agents. The performance of a Vitl Co-Mix in mixing solutions containing a higher proportion of glycerol in various tubes and microplates was evaluated in this study. [More]
  • Vitl’s Bespoke Lab Equipment Solutions Optimize Customer Methods

    Vitl’s Bespoke Lab Equipment Solutions Optimize Customer Methods

    Since Vitl was established as an engineering company, it can produce custom-made lab products and software that are optimized for users’ methods. This article provides a few examples of how Vitl has customized its lab products in the past. [More]
  • Medway School of Pharmacy Team Reproducibly Produces and Tests Nanomaterials Using Vitl's Mixers

    Medway School of Pharmacy Team Reproducibly Produces and Tests Nanomaterials Using Vitl's Mixers

    Nanoparticles are tiny delivery vehicles that can travel to regions where no drugs have gone before and provide the treatment at the right dose and time, with little to no side-effects. They have long been considered as having the potential to transform the future of medicine. In this article, Dr Vladimir Gubala, lecturer in Chemistry and Drug Delivery at the Medway School of Pharmacy, describes the challenges and benefits of using Vitl's Co-Mix. [More]
  • History and Product Range of Vitl Life Science Solutions

    History and Product Range of Vitl Life Science Solutions

    Vitl is a brand within the Integrated Technologies Ltd (ITL) group, which is a global product development and manufacturing company. The group has more than four decades of experience in instrument design and manufacturing projects, targeting medical devices, in vitro diagnostics (IVD), and laboratory equipment. The dedicated development team consists of ex-ITL engineers who have developed all Vitl products using this experience. This article discusses the team’s main milestones. [More]
  • How do you make a filterwheel step more quickly?

    How do you make a filterwheel step more quickly?

    A more powerful motor can be used to make the filterwheel step more rapidly. However, there are many other methods available to perform this task and those approaches are described here in this article. With a little manipulation of the laws of physics, we at Cairn, have used these methods in the design of our Optospin system. [More]
  • Treating Brain Disorders with Non-Invasive Ultrasound Technique

    Treating Brain Disorders with Non-Invasive Ultrasound Technique

    The brain is known to be a well-protected organ and for many years, the ability to treat brain disorders has been limited due to the difficulty in accessing this critical organ. As such, the availability of therapies for disorders such as multiple sclerosis, Parkinson's disease and Alzheimer's disease, is limited. For many patients diagnosed with brain cancer, the complications involved in drug delivery and surgery also mean a poor patient prognosis. The brain is protected, firstly, by the skull and, secondly, by the blood-brain barrier, which is impermeable to almost all small-molecule drugs. [More]
  • Quantitative Measurement of Active Neutrophil Elastase Levels Using ProteaseTag™ Active NE Immunoassay

    Quantitative Measurement of Active Neutrophil Elastase Levels Using ProteaseTag™ Active NE Immunoassay

    Lung function may be affected due to cycles of prolonged inflammation as well as chronic infection of the airways that lead to respiratory diseases like chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). [More]
  • Raman microscopy and redox biology

    Raman microscopy and redox biology

    Raman spectroscopy is highly sensitive in the detection of haem proteins and is ideal for studying their redox biology, something that can be achieved without requiring these proteins to be isolated or stained. The technique can be used to determine redox states within biological systems, allowing scientists to research redox dynamics and the effects they have on health regulation and disease. [More]
  • Cell and Tissue Imaging with Raman Microscopy

    Cell and Tissue Imaging with Raman Microscopy

    Raman imaging is a label-free, non-contact analytical technique that can be used to distinguish cell types and visualize subcellular structures without changing the biochemistry of a cell. [More]
  • Analysis of High-Specificity Cellular Proteins Using Multicolor Immunofluorescence Imaging

    Analysis of High-Specificity Cellular Proteins Using Multicolor Immunofluorescence Imaging

    The study of localization of high-specificity cellular proteins is done using multiplex antibodies probes that are conjugated to fluorescent markers. At present, there are different types of fluorescent probes that are used in studying cellular function. Multi-probe imaging can be done at high resolutions. Advanced imaging systems such as cMOS and CCD from QImaging have been designed to give good results. [More]
  • Using Red-Edge Fluorescence Spectroscopy for Studying Protein Structure and Dynamics

    Using Red-Edge Fluorescence Spectroscopy for Studying Protein Structure and Dynamics

    Polar fluorescence probes can be studied for the dynamics and structure of proteins, phospholipid membranes and micelles using red-edge fluorescence spectroscopy. This methodology facilitates the selective excitation of a tiny fraction of fluorescence probes at the red edge of the absorption band with a red-shifted emission spectrum. The emission maximum’s position of such fluorescence red-shifted probes gives information regarding the dynamics and polarity of the microenvironment of a protein. [More]
  • Using Fluorescence Spectroscopy for Quantitative Analysis of Ligand Binding Affinity

    Using Fluorescence Spectroscopy for Quantitative Analysis of Ligand Binding Affinity

    Fluorescence polarization or anisotropy is a novel technique used for measuring the binding of ligands to proteins in the presence of a fluorophore bound to the ligand. This technique is specifically suitable when no changes are detected in other fluorescence properties. [More]
  • Analysis of Lipid-Protein Interactions Using Fluorescence Spectroscopy

    Analysis of Lipid-Protein Interactions Using Fluorescence Spectroscopy

    Analysis of lipid-protein interactions can be studied by recording the collisional quenching by bromine atoms adhered to chains of lipid fatty acids as well as by studying the fluorescence of tryptophan residues. This provides a framework within which to study the nature of these interactions within membranes. [More]
  • Flexible Technology Accelerates Diagnosis of Prostate Cancer

    Flexible Technology Accelerates Diagnosis of Prostate Cancer

    Prostate cancer is a common malignant disease seen in men, which accounts for almost one-third every year of all the new diagnoses made for cancer. When this disease is detected in its early stages, before it has spread, it can be treated through prostatectomy or radiotherapy. However, the current diagnostic methods of early diagnosis and screening have certain downsides and are a topic of much debate. [More]
  • Intracytoplasmic Sperm Injection Using Eppendorf Transferman® 4m Micromanipulator

    Intracytoplasmic Sperm Injection Using Eppendorf Transferman® 4m Micromanipulator

    Studies on assisted fertilization via micromanipulation techniques have gradually evolved from 1988 to the present day. The technique of intracytoplasmic sperm injection or ICSI (Figure 1) is a great benefit in providing treatment for infertile couples, especially those patients with male factor. [More]
  • Eppendorf TransferMan® 4r – All-Encompassing Manipulator for Genetic Engineering Techniques

    Eppendorf TransferMan® 4r – All-Encompassing Manipulator for Genetic Engineering Techniques

    The modification of laboratory animal genomes is carried out by micromanipulation of embryos or oocytes. The usual techniques of micromanipulation are: transcription activator-like effector nuclease (TALEN) into the cytoplasm into a pronucleus of early zygotes; or microinjection of nucleic acid constructs like larger bacterial artificial chromosomes (BAC), simple transgenes, and zinc finger (ZFN). [More]
  • Ramp Rate Data Alone Not Enough for Evaluation of PCR Thermal Cyclers

    Ramp Rate Data Alone Not Enough for Evaluation of PCR Thermal Cyclers

    In order to compare various thermal cycler speeds, it is not enough to take into account only the heating ramp rate and cooling ramp rate available in the technical specifications, as these data do not give a picture of the actual run times. [More]
  • Dual Block Thermocycler Mastercycler® nexus GX2 Allows PCR Optimization, Offers High Flexibility

    Dual Block Thermocycler Mastercycler® nexus GX2 Allows PCR Optimization, Offers High Flexibility

    Flexible application options are essential for optimal utilization of laboratory instruments in many laboratories. In those laboratories where more than one user is dependent on a single instrument, flexible operation can result in usage frequency. [More]
  • Clinigen’s role in global specialty pharmaceuticals

    Clinigen’s role in global specialty pharmaceuticals

    Clinigen Group is a global specialty pharmaceuticals and services company headquartered in Burton on Trent in the UK. Started in 2010 by CEO Peter George merging the companies Keats Healthcare, Clinigen and Clinigen Healthcare, the organisation now provides services in over 130 countries. As well as the UK, the company has offices in the US, Japan, Australia, South Africa and Singapore. [More]
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