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Medical and Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in medical research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

  • Lipoproteins and Their Applications

    Lipoproteins and Their Applications

    Lipids are a group of organic compounds that include fatty acids (or their derivatives), steroids, waxes, and many natural oils. These compounds can be dissolved in organic solvents but are insoluble in water. [More]
  • Neuroendocrine tumors and radiopeptide imaging

    Neuroendocrine tumors and radiopeptide imaging

    Despite the relatively high occurrence of neuroendocrine tumors, for many years they have proved difficult to diagnose and treat... [More]
  • Preparation of Mouse Peritoneal Macrophages Using Thioglycolate Solution

    Preparation of Mouse Peritoneal Macrophages Using Thioglycolate Solution

    During the preparation of primary mouse peritoneal macrophages, researchers have the option of either using the few resident peritoneal macrophages typically present in their preferred mouse line or injecting thioglycolate broth into the peritoneum, which significantly boosts the quantity of peritoneal macrophages. [More]
  • In Vitro Formation of Macrophage-Derived Foam Cells

    In Vitro Formation of Macrophage-Derived Foam Cells

    The presence of lipid droplet filled cells is a key features of the atherosclerotic lesion that forms in the arterial wall in vivo. These cells are referred to as foam cells. It is now thought that most foam cells in the arterial wall are derived from monocytes that move to the site during the formation of this lesion. [More]
  • Formation of Macrophage-Derived Foam Cells

    Formation of Macrophage-Derived Foam Cells

    THP-1 is a monocytic cell line that is typically obtained from patients suffering from monocytic leukemia. It has been used across a wide range of fields such as genomics, toxicology, immunology, and also in atherosclerosis and cardiovascular studies. [More]
  • Technical Overview on Spinning Disk Confocal Laser Microscopy

    Technical Overview on Spinning Disk Confocal Laser Microscopy

    This article offers an overview of spinning disk confocal laser microscopy and explains why it is more beneficial than confocal microscopy. In traditional widefield optical microscopy, the sample is broadly illuminated with excitation light. [More]
  • Rapid Identification of Single Virus Particles Using Virus Biosensor

    Rapid Identification of Single Virus Particles Using Virus Biosensor

    The use of biosensors for detecting virus particles has attracted significant interest over recent years. To effectively counteract viral epidemics, outbreaks, or bioterrorism, the presence of any viral particles in contaminated food or water or in a patient’s sample needs to be detected quickly. [More]
  • Optimizing Live Cell Imaging with FRET Microscopy Technique

    Optimizing Live Cell Imaging with FRET Microscopy Technique

    Förster resonance energy transfer (FRET) is a popular microscopy technique that is used to determine the proximity of two fluorophores. Resonance energy transfer only takes place across very short distances, usually within 10 nm. The technique involves excited state energy being directly transferred to an acceptor fluorophore from the donor fluorophore, providing an alternative to fluorescence emissive decay from the donor. [More]
  • 3D Structured Illumination Microscopy Provides New Insights into Cell Nucleus

    3D Structured Illumination Microscopy Provides New Insights into Cell Nucleus

    Structured illumination microscopy (SIM) and saturated structured-illumination microscopy (SSIM) techniques provide excellent alternatives to current microscopy methods. [More]
  • Evaluation of Biological Specimens Using CytoFLEX Flow Cytometer

    Evaluation of Biological Specimens Using CytoFLEX Flow Cytometer

    Senior research and development scientists at Beckman Coulter along with other research laboratories, used Beckman Coulter’s CytoFLEX flow cytometers to assess biological samples. These samples included human leukocyte control cells and fresh human whole blood, as well as smaller particles and cells such as microbes, vesicles, liposomes, platelets and red blood cells (RBCs). [More]
  • Performance Testing of CytoFLEX Flow Cytometer

    Performance Testing of CytoFLEX Flow Cytometer

    Cytometry is a widely used biological technique that is used to characterize different cell parameters. In this article, performance testing of the CytoFLEX flow cytometer was carried out to ascertain its ability to perform highly complex applications. To that end, the new CytoFLEX flow cytometer from Beckman Coulter was evaluated against the performance measurements for small particle resolution, population resolution, dynamic range, sensitivity, stability, linearity, and reproducibility. Performance expectations across various parameters were assessed using commercially available bead standards. [More]
  • Measurement of Reactive Oxygen Species in Different Cell Types

    Measurement of Reactive Oxygen Species in Different Cell Types

    New evidence shows that reactive oxygen species (ROS) play an important role in cell signaling and cell cycling. They have been shown to be key in gene expression, apoptosis, and the activation of cell signaling cascades. [More]
  • Characterization of Excitation and Emission Spectra of Commonly Used Variants of Green Fluorescent Proteins

    Characterization of Excitation and Emission Spectra of Commonly Used Variants of Green Fluorescent Proteins

    Green fluorescent proteins are increasingly being utilized in cellular and molecular biology applications. Owing to the wide range of applications, a number of variants of the original wild type green fluorescent protein (wtGFP) have been designed. [More]
  • Magnetic Nanoparticle Mediated Biofilm Treatment

    Magnetic Nanoparticle Mediated Biofilm Treatment

    Biofilms occur when bacterial colonies adhere onto a surface and excrete a polymeric matrix, within which they can then proliferate and aggregate to form a bacterial film. [More]
  • Spectra of Lidocaine Using EFT NMR

    Spectra of Lidocaine Using EFT NMR

    Lidocaine is a widely used local anesthetic and anti-arrhythmic drug with an immediate onset of action. Lidocaine is used topically to alleviate the burning, itching, and pain caused by skin inflammations. It is also used as an anesthetic in dentistry and minor surgeries. Oral gels containing lidocaine are applied to relieve tooth pain. [More]
  • Using EFT NMR to Determine Spectra of Propyl benzoate

    Using EFT NMR to Determine Spectra of Propyl benzoate

    Propyl benzoate or benzoic acid propyl ester is a naturally occurring, organic chemical compound found in clove stems and sweet cherry. This compound has a broad range of useful applications. It is used as a synthetic food flavoring due to its nutty odor and sweet taste and as a preservative in the cosmetic industry due to its antimicrobial properties. [More]
  • EFT-90 Spectra of Ibuprofen Organic Molecules

    EFT-90 Spectra of Ibuprofen Organic Molecules

    Ibuprofen (C13H18O2), previously named (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid, contains the molecular fragments propionic, iso-butyl and phenyl. [More]
  • Advantages of Using Eft NMR Spectrometer in Teaching Laboratories

    Advantages of Using Eft NMR Spectrometer in Teaching Laboratories

    Nuclear magnetic resonance (NMR) spectroscopy is a research technique that exploits the magnetic properties of atomic nuclei to determine the chemical and physical characteristics of the molecules or atoms containing them. [More]
  • Using 3D Super-Resolution Microscopic Technique for Whole Cell Imaging

    Using 3D Super-Resolution Microscopic Technique for Whole Cell Imaging

    ... [More]
  • Using Selective Plane Illumination Microscopy for Imaging Biological Samples

    Using Selective Plane Illumination Microscopy for Imaging Biological Samples

    Prototype systems used in developmental biology use a wide range of transgenic animals, in which individual cells, specific tissues or whole embryos are labeled with fluorescent proteins. These fluorescent transgenic organisms make it possible to observe the behavior of cells and tissues during developmental processes, in real time and at high resolution. Such observations may lead to a better understanding about the various mechanisms involved in shaping a complex organism. This is something that is often limited by the technical limitations of imaging apparatus. [More]
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