Frequent TV watching links to higher white matter lesion volume

	Women's Health
	The latest women's health news from News Medical

ARIC researchers linked self-reported TV watching and occupational sitting in midlife with brain MRI measures obtained roughly 24 years later in 1,712 adults without dementia. Frequent TV watching was associated with greater white matter hyperintensity volume and lower volumes in several brain regions, while sitting at work was associated with lower white matter hyperintensity volume and larger selected cortical volumes.

Longer activity bouts link to lower future dementia and mental health risks

A UK Biobank analysis of 66,483 adults found that longer daily moderate-to-vigorous activity bouts and less fragmented activity were associated with lower subsequent risks of inpatient diagnoses of dementia, depression, and anxiety, independent of total activity time.

			Review finds blueberry and grape polyphenols may improve vascular health A review of 37 publications found that grape- and blueberry-derived polyphenols were associated with modest improvements in cardiovascular risk markers, particularly endothelial function. However, most studies were small or short-term, frequently tested concentrated products, and measured biomarkers rather than cardiovascular events.

			Higher neuroticism may curb strenuous exercise, genetic analysis suggests Researchers used a UK survey and genetic data to examine whether higher neuroticism is associated with lower exercise engagement. Under the study’s Mendelian randomization assumptions, higher neuroticism was estimated to reduce participation in moderate and vigorous physical activity, while conscientiousness may lessen this effect.

	Red meat intake emerges as a potential pancreatic cancer risk factor A systematic review and meta-analysis of 16 studies involving nearly 2 million participants found that higher red meat intake was associated with a modestly higher risk of pancreatic cancer. Processed meat intake showed no statistically significant association, although variation between studies means a small effect cannot be excluded.

	Spermidine boosts key cellular processes linked to aging in early research This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

	We underestimate how much personality changes with age, study finds Researchers compared beliefs from 887 US adults with modeled lifespan trajectories from 166,971 participants across eight longitudinal studies. Population-average Big Five traits changed as much as or more than many health, financial, psychological, and social measures, despite people perceiving personality as unusually stable.

	Study finds greater social jetlag linked to a later eating pattern In a 14-day study of 101 healthy UK adults, greater social jetlag was associated with a later distribution of energy intake, particularly greater late-evening intake among women. The effects were modest, varied by sex and day type, and did not establish whether total daily energy intake differed between groups.

	Longer lives now come with more years spent in poor health worldwide Global life expectancy rose from 64.6 to 73.8 years between 1990 and 2023, but healthy life expectancy did not keep pace. The widening morbidity gap means most populations now spend a decade or more in poor health.

	Short-term immunosuppressive therapy briefly restores autism-like brain changes in adult mice A new mouse study led by UCLA Health suggests that inflammation during pregnancy can trigger autism-like changes in offspring, but also that those brain and behavior effects may be rapidly but temporarily reversible in adulthood with a short-term dose of the immunosuppressive drug rapamycin.

	Planetary Health Diet lowers cardiovascular risk in older women A 20-year study of more than 65,000 postmenopausal women found that higher adherence to the Planetary Health Diet was associated with a lower risk of overall cardiovascular disease, coronary heart disease, stroke and heart failure.

	This edible flower could do more than brighten a plate A review of 76 publications finds that pot marigold contains more than 500 reported secondary metabolites, along with natural pigments, antioxidants, and substantial dietary fiber. Early food studies report promising results in yogurt, bread, pasta, and edible oils, but limited product trials and no clinical evidence currently prevent human health claims.

	AI model predicts cancer diagnoses up to a year in advance using routine clinical data Researchers developed Oncoformer, a multimodal transformer that analyzes longitudinal health records and chest X-rays to classify cancer, predict diagnoses up to one year in advance, infer tumor stage, and forecast treatment response and recurrence risk. Validation across large independent cohorts showed strong performance, although prospective trials in diverse, average-risk populations are needed before clinical use.

	Parenthood impacts women's health more than men's health According to OPIK, the research group of the EHU-University of the Basque Country, the arrival of children is associated with changes in women's health that are not observed in men's health.

	AI mental health chatbots feel empathetic, but safety evidence still lags Immune dysregulation may contribute to depression, schizophrenia, bipolar disorder, and anxiety through chronic inflammation, altered neuroimmune signaling, genetic susceptibility, and stress-related epigenetic changes. Evidence also suggests that biologically defined patient subgroups may benefit from more precise, immune-informed approaches to diagnosis and treatment.

	Semaglutide and tirzepatide linked to fewer alcohol-related hospital visits Newer GLP-1 receptor agonists, including semaglutide and tirzepatide, were associated with fewer alcohol-related ED visits or hospitalizations among adults with alcohol use disorder and type 2 diabetes or obesity.

	Alcohol use during pregnancy increased in the United States from 2011 through 2024 Prenatal alcohol exposure-a contributor to adverse pregnancy outcomes and the leading preventable cause of neurodevelopmental disability worldwide-has increased in the United States over the past decade.

	Phase 3 clinical trial enrolls first platinum-resistant ovarian cancer patient The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3132/BEHOLD-Ovarian01 (NCT07286266), a global Phase 3 clinical trial titled A Randomized, Open-label, Multicenter, Phase 3 Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants with Platinum-resistant Ovarian Cancer.

	Prolactin activates brain pathway promoting maternal caregiving behavior New research has found a hormone is responsible for making mothers' interactions with newborns feel rewarding rather than just necessary.

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