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Nirsevimab slashes RSV hospitalizations in infants by 78% in real-world study

A Spanish study found that nirsevimab prophylaxis significantly reduced infant hospitalizations, ICU admissions, and severe symptoms linked to RSV and other respiratory viruses. Hospitalizations for RSV dropped by 78% following nirsevimab rollout in Madrid maternity wards.

8 May 2025

Long-acting HIV drug emerges from decades of research and advocacy

In the hunt for a remedy, when the baton is passed from dedicated academic scientists to an innovative company to trusted community advocates, outcomes for society can be especially powerful.

8 May 2025

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

HIV drugs found to significantly reduce Alzheimer's risk in new study

UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer's disease after discovering that patients taking the drugs are substantially less likely to develop the memory-robbing condition.

8 May 2025

Most deadly drug-resistant infections in poorer countries go untreated, study shows

A new modelling study reveals that only 7% of carbapenem-resistant Gram-negative (CRGN) bacterial infections in eight LMICs receive effective antibiotic treatment. This stark undertreatment poses a major threat in the global fight against antimicrobial resistance (AMR).

7 May 2025

Why a major hydroxychloroquine study was retracted over statistical misuse

Researchers reanalyzed a retracted HCQ study that claimed over 16,000 COVID-19 deaths and exposed serious methodological flaws, including inappropriate use of effect sizes and lack of dose-specific analysis. The study calls for urgent reform in peer review and greater transparency in scientific publishing.

6 May 2025

Retail pharmacies excluded from Medicare Part D networks at higher risk of closure

Retail pharmacies excluded from Medicare Part D networks maintained by drug benefits middlemen were much more likely to close over the past decade, according to new research from USC published in Health Affairs.

6 May 2025

Diabetes drug shows promise for treating prostate cancer

An international team of scientists led by the Medical University of Vienna has identified similarities in the mechanisms of diabetes and cancer: as the researchers show, the protein PPARγ, which is central to the regulation of metabolic processes, can also influence the growth of prostate cancer cells.

6 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

Scientists use AI to build mutation-proof antibodies for SARS-CoV-2

Researchers used AI models to design antibodies that neutralize over 1,300 SARS-CoV-2 strains, including Delta and Omicron. The models demonstrated faster, cheaper, and more adaptable therapeutic development compared to traditional methods.

5 May 2025

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). The interim results also reveal meaningful weight loss and improved cardiometabolic markers, with a favorable safety profile.

4 May 2025

New three-part antivenom cocktail protects against the world’s deadliest snakes

Scientists developed a groundbreaking antivenom cocktail using antibodies from a hyperimmune human donor and a small-molecule inhibitor that protected mice from deadly bites of 19 diverse snakes. This approach could lead to a universal antivenom for the world’s most dangerous snakes, overcoming the limitations of current species-specific treatments.

2 May 2025

New antiviral compounds show broad protection against COVID-19 variants

Novel Mpro inhibitors exhibit broad activity against SARS-CoV-2 and other coronaviruses.

30 Apr 2025

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

Neoadjuvant PD-1 blockade with dostarlimab achieved high rates of organ preservation in patients with early-stage mismatch repair-deficient (dMMR) solid tumors across multiple types. Most patients avoided surgery with durable disease control, reshaping potential cancer treatment pathways.

28 Apr 2025

Medicare changes set to lower out-of-pocket costs for cancer medications

Even for patients covered by Medicare, annual out-of-pocket costs for lifesaving cancer treatments taken in pill form have often exceeded $10,000-until recently.

28 Apr 2025

New Medicare changes ease cost burden for cancer drugs

Even for patients covered by Medicare, annual out-of-pocket costs for lifesaving cancer treatments taken in pill form have often exceeded $10,000-until recently.

25 Apr 2025

New era of medicine emerges through structural control of nanotherapeutics

Historically, the vast majority of pharmaceutical drugs have been meticulously designed down to the atomic level.

25 Apr 2025

Network pharmacology analysis reveals HXTL mechanism in treating postmenopausal osteoporosis

Huo Xue Tong Luo Capsule (HXTL) has been clinically used to treat osteonecrosis of the femoral head, osteoporosis, and other bone and joint diseases with promising effects.

24 Apr 2025

Antibiotic use by humans is polluting rivers across the globe, study shows

A global modeling study found that 8,500 tonnes of antibiotics from human use alone enter rivers annually, threatening aquatic ecosystems and accelerating antimicrobial resistance. Over 6 million kilometers of river length exceed safety thresholds, especially in low- and middle-income countries with limited wastewater treatment.

24 Apr 2025

What’s behind Gen Z’s skepticism about Ozempic and Wegovy

A U.S. study of over 500 youth aged 14–24 found high awareness but widespread hesitation about using semaglutide for weight loss. Concerns focused on safety, social stigma, and a preference for lifestyle changes like diet and exercise.

24 Apr 2025