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Added benefit of lung cancer drug not proven, says IQWiG

Added benefit of lung cancer drug not proven, says IQWiG

Afatinib (trade name: Giotrif) has been approved since April 2016 for the treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) of squamous histology who have already received chemotherapy. [More]
Added benefit not proven for orphan drug in treatment of adults with stomach cancer

Added benefit not proven for orphan drug in treatment of adults with stomach cancer

Ramucirumab (trade name: Cyramza) is a monoclonal antibody, which blocks a receptor, reducing the growth of blood vessels and so reducing blood supply to the tumours. [More]

Added benefit still not proven for epilepsy drug

Brivaracetam (trade name: Briviact) has been approved since January 2016 as add-on therapy for adults and adolescents from 16 years of age with epileptic seizures. [More]
Many parents support HPV vaccine school-entry requirements with opt-out provisions

Many parents support HPV vaccine school-entry requirements with opt-out provisions

Requiring students to get vaccinated against the human papillomavirus, or HPV, to enter school could prevent many cancers linked to the virus, but University of North Carolina at Chapel Hill researchers found that many parents only support such requirements with opt-out provisions that could make the laws less effective. [More]
Men experience greater pain relief than women after smoking marijuana, study finds

Men experience greater pain relief than women after smoking marijuana, study finds

Researchers from Columbia University Medical Center found that men had greater pain relief than women after smoking marijuana. [More]
TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

An international team led by scientists at The Scripps Research Institute has found strong evidence supporting a new strategy against drug addiction. [More]
Popular pain and fever reliever does not worsen asthma in children, study shows

Popular pain and fever reliever does not worsen asthma in children, study shows

WIn a study of children with mild, persistent asthma, scientists found that acetaminophen was tolerated without the worsening of asthma, when compared with ibuprofen use. [More]
Diabetes medication offers protection against arterial stiffness in overweight female mice

Diabetes medication offers protection against arterial stiffness in overweight female mice

Obesity and Type 2 diabetes are associated with vascular stiffening and the development of cardiovascular disease. [More]
Research findings open avenues for creating new classes of anticancer drugs

Research findings open avenues for creating new classes of anticancer drugs

A new study at Los Alamos National Laboratory and in collaboration with Stanford Synchrotron Radiation Lightsource greatly improves scientists' understanding of the element actinium. The insights could support innovation in creating new classes of anticancer drugs. [More]
New book from Cold Spring Harbor examines major antibiotics and mechanisms of resistance

New book from Cold Spring Harbor examines major antibiotics and mechanisms of resistance

One of the greatest medical accomplishments of the past century was the introduction of antibiotics into the clinic. [More]
Low adherence to antipsychotic medication linked to long-term homelessness

Low adherence to antipsychotic medication linked to long-term homelessness

SFU health sciences researcher Stefanie Rezansoff has published a new study on the treatment of serious mental illnesses among people who are homeless. This is the first study to investigate adherence to antipsychotic medication in this population. [More]
T-sol can be safe and effective treatment for men with hypogonadism

T-sol can be safe and effective treatment for men with hypogonadism

For men with hypogonadism, a condition in which the body does not produce enough testosterone, low sex drive and fatigue are common symptoms. [More]
Steroid treatment linked to increased risk of retinopathy in very low birth weight infants

Steroid treatment linked to increased risk of retinopathy in very low birth weight infants

Because of the beneficial effect of corticosteroids on lung function, especially in infants who are ventilator dependent, corticosteroids are, at times, administered to very low birth weight neonates to treat established or evolving lung disease. However, it has long been suspected that steroids may have negative neurodevelopmental effects on very premature infants. [More]
New guidance provides effective practices for prehospital use of TXA in injured patients

New guidance provides effective practices for prehospital use of TXA in injured patients

Tranexamic acid (TXA) is currently being administered to injured patients by many prehospital air and ground systems, despite a lack of evidence supporting or refuting its efficacy in preventing hemorrhage. [More]
NIH funds collaborative project to develop better vaccine adjuvants for many diseases

NIH funds collaborative project to develop better vaccine adjuvants for many diseases

Dr. Qizhi Cathy Yao, professor of surgery, molecular virology and microbiology, and pathology & immunology at Baylor College of Medicine, has been awarded a National Institutes of Health grant to fund a collaborative project with Molecular Express, Inc. [More]
Intestinal flora likely to have effect on person's response to drugs

Intestinal flora likely to have effect on person's response to drugs

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs. [More]
RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

The latest lists developed by specialties from the Royal Australasian College of Physicians as part of the Choosing Wisely Australia initiative deliver a strong message on appropriate use of medicines for older Australians. [More]
EPFL scientists develop new method to cheaply produce chemical compounds

EPFL scientists develop new method to cheaply produce chemical compounds

EPFL scientists design a new method to cheaply produce some of the most important chemical compounds in the pharmaceutical industry - the amines. [More]
FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL). [More]
Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not. [More]
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