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Combinations of three antibiotics could help combat drug-resistant bacterial infections

Combinations of three antibiotics could help combat drug-resistant bacterial infections

Each year, approximately 700,000 people die from drug-resistant bacterial infections. A study by UCLA life scientists could be a major step toward combating drug-resistant infections. [More]
Scientist develops new method for identifying proteins to build new biologics

Scientist develops new method for identifying proteins to build new biologics

A University of Toronto scientist has developed a new method for identifying the raw ingredients necessary to build 'biologics', a powerful class of medications that has revolutionized treatment of diseases like rheumatoid arthritis and some cancers. [More]
New neuroprotective compounds may prevent development of epilepsy

New neuroprotective compounds may prevent development of epilepsy

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy. [More]
Scientists design and construct 10 large protein icosahedra to improve drug delivery

Scientists design and construct 10 large protein icosahedra to improve drug delivery

Using novel computational and biochemical approaches, scientists have accurately designed and built from scratch 10 large protein icosahedra--polyhedra with 20 faces--similar to viral capsids that carry viral DNA. [More]
Adults with pain could be at higher risk of developing prescription opioid use disorders

Adults with pain could be at higher risk of developing prescription opioid use disorders

What do we really know about the relationship between the experience of pain and risk of developing opioid use disorder? Results from a recent study - the first to directly address this question -- show that people with moderate or more severe pain had a 41 percent higher risk of developing prescription opioid use disorders than those without, independent of other demographic and clinical factors. [More]
Texas Biomed scientists receive $23 million NIH grant to develop AIDS vaccine

Texas Biomed scientists receive $23 million NIH grant to develop AIDS vaccine

To support a coordinated, innovative approach to the development of an AIDS vaccine, Texas Biomedical Research Institute scientists, together with a multi-institutional coalition of experts from the United States and Europe, have received a grant for $23 million from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. [More]
Patients with cLBP more likely to use illicit drugs, study reports

Patients with cLBP more likely to use illicit drugs, study reports

People living with chronic low back pain (cLBP) are more likely to use illicit drugs -- including marijuana, cocaine, heroin, and methamphetamine -- compared to those without back pain, reports a study in Spine, published by Wolters Kluwer. [More]
BET inhibitor treatment decreases lung inflammation in mice

BET inhibitor treatment decreases lung inflammation in mice

Patients with cystic fibrosis (CF) suffer from chronic respiratory infections, primarily caused by Pseudomonas aeruginosa, which lead to airway inflammation and damage. [More]
Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutron crystallography allows us to determine the three-dimensional structures of biological macromolecules, such as proteins, by means of the diffraction of neutrons from the regularly spaced atoms of a crystal. [More]
Improving efficiency of health facilities could extend ART to many people living with HIV

Improving efficiency of health facilities could extend ART to many people living with HIV

Health facilities in Kenya, Uganda, and Zambia could extend life-sustaining antiretroviral therapy (ART) to hundreds of thousands of people living with HIV if facilities improved the efficiency of service delivery. [More]
Study provides new insights into real-world use of PrEP

Study provides new insights into real-world use of PrEP

Several studies presented today in an official press conference at the 21st International AIDS Conference in Durban provided new insights on the use of PrEP among a broad range of populations. [More]
GSK and University of Leicester team up to develop novel drugs to treat blood cancer

GSK and University of Leicester team up to develop novel drugs to treat blood cancer

A collaboration between the University of Leicester and global pharmaceutical company GlaxoSmithKline has been established to discover and develop novel medicines to treat aggressive forms of blood cancer. [More]
Long-term antibiotic treatment slows progression of Alzheimer's disease through changes in gut bacteria

Long-term antibiotic treatment slows progression of Alzheimer's disease through changes in gut bacteria

Long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago. [More]
Scientific review cautions against unnecessary use of antioxidant supplements

Scientific review cautions against unnecessary use of antioxidant supplements

The lay press and thousands of nutritional products warn of oxygen radicals or oxidative stress and suggest taking so-called antioxidants to prevent or cure disease. [More]
TSRI study reveals new approach to intervene in deadly disease

TSRI study reveals new approach to intervene in deadly disease

In a new study, scientists at The Scripps Research Institute have identified drug candidates that can boost a cell's ability to catch the "typos" in protein production that can cause a deadly disease called amyloidosis. [More]
Penn researchers develop plant-based oral vaccine booster

Penn researchers develop plant-based oral vaccine booster

Jonas Salk created a vaccine against polio that has been used since 1955; Albert Sabin created another version that has been on the market since 1961. Together, these two vaccines have nearly eliminated polio from the face of the earth. [More]
Study confirms efficacy of PrEP in reducing risk of HIV infection in men who have sex with men

Study confirms efficacy of PrEP in reducing risk of HIV infection in men who have sex with men

The last phase of ANRS IPERGAY has confirmed that "on-demand" pre-exposure prophylaxis (PrEP) is a highly effective method of reducing the risk of HIV infection in men who have sex with men and who report high-risk behavior. [More]
Researchers find dangerous antibiotic-resistant bacteria in wastewater from broken sewer lines

Researchers find dangerous antibiotic-resistant bacteria in wastewater from broken sewer lines

University of South Florida researchers investigating the aftermath of a September, 2014 sewer line break in St. Petersburg, Florida, have found dangerous antibiotic-resistant bacteria in the untreated wastewater that gushed into neighborhoods and into Boca Ciega Bay at a rate of 250 to 500 gallons per minute. [More]
Risk of hypoglycemia differs between SU agents, study reveals

Risk of hypoglycemia differs between SU agents, study reveals

Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs-which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide-stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body. [More]
Antibiotic usage, infections may contribute to manic episodes in people with mental disorders

Antibiotic usage, infections may contribute to manic episodes in people with mental disorders

In research using patient medical records, investigators from Johns Hopkins and Sheppard Pratt Health System report that people with serious mental disorders who were hospitalized for mania were more likely to be on antibiotics to treat active infections than a group of people without a mental disorder. [More]
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