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UNC researchers map anxiety circuit in the brain that may explain side effects of antidepressants

UNC researchers map anxiety circuit in the brain that may explain side effects of antidepressants

More than 100 million people worldwide take selective serotonin reuptake inhibitors (SSRIs), such as Prozac and Zoloft, to treat depression, anxiety and related conditions, but these drugs have a common and mysterious side effect: they can worsen anxiety in the first few weeks of use, which leads many patients to stop treatment. [More]
Atomic level analysis reveals how two classes of calcium channel blockers produce different effects

Atomic level analysis reveals how two classes of calcium channel blockers produce different effects

An atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects through their actions at different sites on the calcium channel molecule. [More]
NIBIB researchers develop nanovaccine to enhance cancer immunotherapy

NIBIB researchers develop nanovaccine to enhance cancer immunotherapy

NIBIB researchers have created a nanovaccine that could make a current approach to cancer immunotherapy more effective while also reducing side effects. [More]
Study finds THC in marijuana affects rats' willingness to exert cognitive effort

Study finds THC in marijuana affects rats' willingness to exert cognitive effort

New research from the University of British Columbia suggests there may be some truth to the belief that marijuana use causes laziness-- at least in rats. [More]
Diabetes drug linked to decreased weight gain in children with autism spectrum disorder

Diabetes drug linked to decreased weight gain in children with autism spectrum disorder

The diabetes medication metformin hydrochloride was associated with decreased weight gain in a small clinical trial of children and adolescents with autism spectrum disorder who were taking atypical antipsychotics to treat symptoms of irritability and agitation, according to an article published online by JAMA Psychiatry. [More]
New method estimates patient adherence to antiretroviral drugs

New method estimates patient adherence to antiretroviral drugs

Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at CU Anschutz have developed a technique that estimates an HIVnegative patient's adherence to drugs prescribed to prevent HIV transmission during sex. [More]
Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Geroscience researchers studying the biology of aging briefly treated middle-aged mice with the drug rapamycin to gauge the long-term effects of short-term therapy on health and longevity. [More]
Portable Lab-on-a-Stick test helps in rapid detection of bacterial resistance to antibiotics

Portable Lab-on-a-Stick test helps in rapid detection of bacterial resistance to antibiotics

A portable power-free test for the rapid detection of bacterial resistance to antibiotics has been developed by academics at Loughborough University and the University of Reading. [More]
MDI Biological Laboratory researchers receive patent for novel heart disease drug

MDI Biological Laboratory researchers receive patent for novel heart disease drug

The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D., for use of the small molecule MSI-1436 to stimulate the repair and regeneration of heart tissue damaged by injuries such as a heart attack. [More]
TMDU researchers inject gelatin-based gel carrying protein/peptide drugs to trigger bone augmentation

TMDU researchers inject gelatin-based gel carrying protein/peptide drugs to trigger bone augmentation

The part of the jawbone containing tooth sockets is known as alveolar bone, and its loss over time or following dental disease may ultimately result in tooth loss. [More]
Cloned Zika virus could be used for development of attenuated vaccine

Cloned Zika virus could be used for development of attenuated vaccine

Stopping the explosive spread of Zika virus - which can lead to birth defects in babies born to infected mothers - depends on genetic insights gleaned through new tools and models. [More]
New drug target could help prevent opioid tolerance and addiction

New drug target could help prevent opioid tolerance and addiction

Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University. [More]
New study aims to find how genes that influence brain function cause risk for drug addiction

New study aims to find how genes that influence brain function cause risk for drug addiction

A new study aims to better understand what makes some individuals particularly vulnerable to developing drug addiction. A team of researchers from across the country will look at how genes that influence brain function cause risk for addictions. [More]
Study looks at ways to reduce prescription drugs linked to fracture risk among older adults

Study looks at ways to reduce prescription drugs linked to fracture risk among older adults

Fragility fractures -- those that occur at standing height -- are a significant source of sickness and death among the elderly population in the United States. They are also associated with annual direct costs of over $16 billion. [More]
QUT molecular microbiologist developing new therapies to beat bacterial superbugs

QUT molecular microbiologist developing new therapies to beat bacterial superbugs

QUT molecular microbiologist Makrina Totsika is at the forefront of research to develop new therapies to beat multi-drug resistant bacteria. [More]

New study examines effectiveness of pictogram labels on medication-related road traffic crash risk

A new study questions the effectiveness of using pictogram message on the labels of anxiety and sleep medications that interfere with driving - an approach this is currently implemented across France. [More]
NYIT researcher aims to study link between wound healing problems and methamphetamine use

NYIT researcher aims to study link between wound healing problems and methamphetamine use

A chance observation in a Southern California fast food restaurant led Luis Martinez, Ph.D., to wonder about the connections behind wound healing problems and methamphetamine use. [More]
Genekam develops first therapeutic molecule candidate for Zika viruses

Genekam develops first therapeutic molecule candidate for Zika viruses

GenekamBiotechnology AG, which developed the first test for Zika virus detection in January 2016, has developed as one of first company in the world the therapeutic molecule candidate for Zika viruses, which is likely to be the first potential candidate for Zika-virus therapy. [More]
Checkpoint inhibitor for treatment of NSCLC patients shows indication of added benefit

Checkpoint inhibitor for treatment of NSCLC patients shows indication of added benefit

Nivolumab has been approved since April 2016 as a checkpoint inhibitor for the treatment of adults with locally advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) who have already undergone chemotherapy. [More]
Added benefit of combination drug for HIV-infected patients not proven

Added benefit of combination drug for HIV-infected patients not proven

The drug combination emtricitabine/tenofovir alafenamide is approved in combination with other antiviral agents for the treatment of adults and adolescents infected with human immunodeficiency virus type 1 (HIV-1). [More]
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