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Non-hormonal male contraceptive effectively prevents pregnancy in mice

Women have many choices for birth control, ranging from pills to patches to intrauterine devices, and partly as a result, they bear most of the burden of preventing pregnancy.

24 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

The coming of spring harkens spring cleaning; a time to de-clutter your home and discard things that are no longer needed. In the body, a cellular process called autophagy occurs regularly to "de-clutter" our cells.

15 Mar 2022

Can wearables transform the future of healthcare?

In partnership with SLAS 2022, we spoke to Professor Michael Snyder about his latest research that investigates wearables and their future within healthcare.

From Society for Laboratory Automation and Screening (SLAS) 14 Mar 2022

Scientists reveal molecular mechanisms behind bone loss caused by chronic liver injury

A research team led by Prof. Chen Di from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences along with other collaborators have revealed the molecular mechanisms behind bone loss caused by chronic liver injury.

1 Mar 2022

CD91 receptor promotes SARS-CoV-2 infection

researchers find that LRP1/CD91 is a leading molecule in virus-host cell interactions that causes infection by many RNA viruses.

22 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

New open-source software tool could accelerate genetic discoveries

Commercially viable biofuel crops are vital to reducing greenhouse gas emissions, and a new tool developed by the Center for Advanced Bioenergy and Bioproducts Innovation should accelerate their development -; as well as genetic editing advances overall.

17 Feb 2022

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa.

16 Feb 2022

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

In a recent study posted to the bioRxiv* pre-print server, a team of researchers demonstrated that ubiquitin-specific peptidase 22 (USP22) is a crucial regulator of basal interferon (IFN) signaling in native human intestinal epithelial cells (hIECs).

7 Feb 2022

CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD.

31 Jan 2022

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

In research recently published in the journal of Science Advances, an interdisciplinary team of researchers from the University of Chicago assessed the potential role of cannabidiol (CBD), a natural product extracted from the cannabis plant, to prevent and inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in human cells and mice.

26 Jan 2022

PAXLOVID shown to be highly effective against all SARS-CoV-2 variants

A recent study, currently available on bioRxiv* preprint server, shows that a novel protease inhibitor known as nirmatrelvir has potent activity against Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also other variants evaluated in this paper – which supports its potential role in reducing the disease burden from coronavirus disease 2019 (COVID-19).

21 Jan 2022

UAB research outlines successful xenotransplantation of genetically modified kidneys

The University of Alabama at Birmingham Marnix E. Heersink School of Medicine announces today the first peer-reviewed research outlining the successful transplant of genetically modified, clinical-grade pig kidneys into a brain-dead human individual, replacing the recipient's native kidneys.

20 Jan 2022

Knockout News and Research

Non-hormonal male contraceptive effectively prevents pregnancy in mice

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

Can wearables transform the future of healthcare?

Scientists reveal molecular mechanisms behind bone loss caused by chronic liver injury

CD91 receptor promotes SARS-CoV-2 infection

Study identifies a protein complex critical for regulating apoptosis and necroptosis

New open-source software tool could accelerate genetic discoveries

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

CRISPRa method helps discover genes that play a role in immune cell biology

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

PAXLOVID shown to be highly effective against all SARS-CoV-2 variants

UAB research outlines successful xenotransplantation of genetically modified kidneys

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

New findings could contribute to future therapeutics for muscle degeneration

Researchers investigate the role of a key component of the circadian clock in heart disease

COPD: Ion channels in immune cells could potentially be targets for new therapies

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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