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Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

It is a known fact that consuming a large amount of alcohol, even for a few days, triggers fat accumulation in the liver and ultimately leads to alcohol-related liver diseases.

13 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

12 Sep 2022

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers.

8 Sep 2022

Cedars-Sinai investigators identify 15 cancer disparities in L.A. County

People in Los Angeles County experience differences in cancer risk and survival depending on a variety of factors such as race/ethnicity, gender, sexual orientation, geographic location and socioeconomic status, according to a new study by investigators at Cedars-Sinai Cancer.

6 Sep 2022

Costly Chemicals; The Health and Economic Impact of 'Forever Chemicals'

With PFAS being commonly found in households worldwide, what are the health and economic impacts of these forever chemicals? In this interview, we speak to Dr. Linda Kahn to find out more!

15 Aug 2022

EPA action boosts grassroots momentum to reduce toxic ‘forever chemicals’

The intake pumps that once drew 6 million gallons of water a day from the Oostanaula River now sit mostly dormant in this northwestern Georgia city.

10 Aug 2022

Researchers collaborate on a 15-month case study to analyze patient’s recovery from impaired adrenocorticotropic hormone

Recently, 'Long COVID' is becoming a significant issue worldwide. It refers to a variety of symptoms that persist over an extended period after the patient has recovered from a novel coronavirus infection (COVID-19). In many cases, it is unclear what causes Long COVID symptoms, and there is insufficient information regarding recovery time.

10 Aug 2022

Biological sex differences may be the reason behind higher cancer risk among men than women

Rates of most types of cancer are higher in men than in women for reasons that are unclear. Results from a recent study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, suggest that the cause may be underlying biological sex differences rather than behavioral differences related to smoking, alcohol use, diet, and other factors.

8 Aug 2022

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

The Alliance for Clinical Trials in Oncology, in partnership with the National Cancer Institute, part of the National Institutes of Health, today announced the opening of a new study for participant enrollment that aims to obtain a reference set of blood samples from newly diagnosed patients with cancer and healthy individuals without cancer to include in a future study to assess the utility of early cancer detection blood tests.

1 Aug 2022

Higher insulin dose is positively linked with cancer incidence, study finds

Dr. Yuanjie Mao has led a study published in the Journal of the American Medical Association (JAMA) Oncology looking at the correlation between daily insulin dose and cancer incidence (the number of new cases) among patients with type 1 diabetes, finding that higher insulin dose is positively associated with cancer incidence and that the association is stronger among those with insulin resistance.

29 Jul 2022

Thyroid News and Research

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Cedars-Sinai investigators identify 15 cancer disparities in L.A. County

Costly Chemicals; The Health and Economic Impact of 'Forever Chemicals'

EPA action boosts grassroots momentum to reduce toxic ‘forever chemicals’

Researchers collaborate on a 15-month case study to analyze patient’s recovery from impaired adrenocorticotropic hormone

Biological sex differences may be the reason behind higher cancer risk among men than women

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

Higher insulin dose is positively linked with cancer incidence, study finds

PFAS exposure harms people's health and undermines America's economy

Scientists develop an improved pharmaceutical drug for the treatment of atrial fibrillation

Pfizer’s SARS-CoV-2 vaccine does not affect the honeymoon phase of type 1 diabetes

As California welcomes Ukrainian refugees, counties fall short on interpreters

Iodine deficiency may be making a comeback due to changing eating habits in Canadian communities

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

Women diagnosed with anorexia nervosa are more likely to have underweight babies

AAP recommends breastfeeding for 2 years

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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