Metabolites News and Research

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New Category I CPT code for AspirinWorks Test Kit

Corgenix Medical Corporation, a worldwide developer and marketer of diagnostic test kits, announced today that a new Category I Current Procedural Terminology (CPT) code has been published by the American Medical Association (AMA) for the AspirinWorks Test Kit.

23 Oct 2009

Migraine can stimulate alcohol-induced headache

Migraine sufferers, beware. You may be more prone to an alcohol-induced headache after a night of drinking, according to researchers from the Jefferson Headache Center.

19 Oct 2009

Blocking folic acid action during early pregnancy leads to increased risk of abnormalities in growing baby

Using medication that reduces or blocks the actions of folic acid during the first trimester of pregnancy (weeks 1-12), increases the risk that the growing baby will develop abnormalities. This conclusion was reached by a team of Epidemiologists, Paediatricians, Clinical Pharmacologists, Obstetricians and Gynaecologists who examined birth and abortion data collected in Israel between 1998 and 2007.

15 Oct 2009

Medications to reduce folic acid during pregnancy increase the risk of abnormalities in fetus

Pregnant women are advised to take vitamin supplements containing folic acid as part of their routine pre-natal care. Now, a new study warns that taking medications that reduce or block the actions of folic acid during the first trimester of pregnancy increase the risk that the growing baby will develop abnormalities.

14 Oct 2009

Research scientists develop bioengineered treatment for targeting pancreatic cancer

Research scientists from Massachusetts General Hospital, Boston, have developed a novel bioengineered treatment that has shown promise in targeting pancreatic cancer without causing damage to healthy noncancer cells, a typical problem of chemotherapy.

14 Oct 2009

Research study to determine association of CYP2D6 variation with tamoxifen therapy

Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a study in the October 7 issue of JAMA.

7 Oct 2009

Central metabolic network model of Thermotoga maritima bacterium developed

Investigators at Burnham Institute for Medical Research (Burnham), University of California, San Diego (UC San Diego), The Scripps Research Institute (TSRI), Genomics Institute of the Novartis Research Foundation (GNF) and other institutions have constructed a complete model, including three dimensional protein structures, of the central metabolic network of the bacterium Thermotoga maritima (T. maritima).

25 Sep 2009

Research program to study personalized medicine

A new collaborative research program that will use the power of metabolomic profiling to help advance the concept of personalized medicine was announced September 17, 2009 by the Burnham Institute for Medical Research and the Sarah W. Stedman Nutrition and Metabolism Center at Duke University Medical Center.

18 Sep 2009

Karo Bio receives US patent for its thyroid hormone receptor platform

The Swedish biotech company Karo Bio today announced that it has expanded and further strengthened the intellectual property portfolio for its thyroid hormone receptor (TR) platform by entering into an agreement that provides Karo Bio with an exclusive license to a US patent from Pfizer Inc.

18 Sep 2009

PSC activation mechanisms help develop novel therapeutic approaches for pancreatic fibrosis

Fibrosis is a key feature of chronic pancreatitis and pancreatic cancer. The extensive deposition of extracellular matrix proteins fosters the development of an exocrine and endocrine organ insufficiency, and accelerates progression of the tumour. Pancreatic stellate cells (PSC) are the principal effector cells in pancreatic fibrosis. They are activated by profibrogenic mediators, which include, for example, cytokines and ethanol metabolites.

18 Sep 2009

DDI Predict 2009 edition assessing the risk of potential drug-drug interactions released

Aureus Pharma, a leading provider of knowledge management solutions to accelerate discovery in the life sciences industry, announces today the release of the 2009 Edition of DDI Predict. This innovative software application adds a number of enhancements to assess the risk of potential drug-drug interactions including those involving multiple enzymatic pathways.

17 Sep 2009

Natural food compounds may play a vital role in cancer treatment

Research in the Linus Pauling Institute at Oregon State University suggests that some natural food compounds, which previously have been studied for their ability to prevent cancer, may be able to play a more significant role in treating it - working side-by-side with the conventional drugs that are now used in chemotherapy.

1 Sep 2009

Researchers reveal that nonextractable polyphenols in fruits are a major part of bioactive compounds

An international team of scientists has found that the polyphenol content of fruits has been underestimated. Polyphenol content in fruits usually refers to extractable polyphenols, but a Spanish scientist working at the Institute of Food Research in Norwich analysed apple, peach and nectarine. She found that nonextractable polyphenol content is up to five times higher than extractable compounds. This work has been published in the Journal of Agricultural and Food Chemistry.

27 Aug 2009

Additional trial to be conducted for KYNAPID under FDA special protocol agreement

Cardiome Pharma Corp. (NASDAQ: CRME/TSX: COM) and its co-development partner Astellas Pharma US, Inc. ("Astellas") announced today that Astellas will undertake a single confirmatory additional Phase 3 clinical trial of KYNAPID(TM) (vernakalant hydrochloride) Injection for rapid conversion of atrial fibrillation to sinus rhythm. The trial, to be called ACT 5, is expected to begin enrolling patients by the end of 2009, with completion expected in the first half of 2011.

11 Aug 2009

Special pathway makes bacteria vulnerable - new target for tailored antibiotics

More and more strains of bacteria are developing resistance to previously life-saving antibiotics. Researchers at TUM, the Technische Universitaet Muenchen, have shed light on a metabolic step that appears in many aggressive microorganisms -- such as tuberculosis and malaria pathogens -- and that may provide a promising target for a new class of antibiotics. The researchers present their results in the chemistry journal Angewandte Chemie.

14 Jul 2009

Scientists shed new light on why pancreatic cancer drugs can fail

Cancer Research UK scientists led an international team of investigators who have discovered a new mechanism that may explain why pancreatic cancer patients are often resistant to a common chemotherapy treatment called gemcitabine, according to a study published in Science.

22 May 2009

Key genetic mechanism a potential key to new class of antibiotics

Researchers have determined the structure of a key genetic mechanism at work in bacteria, including some that are deadly to humans, in an important step toward the design of a new class of antibiotics, according to an accelerated publication that appeared online today as a "paper of the week" in the Journal of Biological Chemistry.

20 Apr 2009

New approach to prostate cancer detection - Sarcosine may distinguish between slow-growing and aggressive prostate cancers

On Friday 20 March, US researcher Dr. Chris Beecher from the University of Michigan gave a well attended lecture about sarcosine, an N-methyl derivative of the amino acid glycine, at the 24th Annual EAU Congress in Stockholm, Sweden.

25 Mar 2009

Researchers identify genetic machinery responsible for synthesizing thiostrepton

Researchers at the Georgia Institute of Technology have identified the genetic machinery responsible for synthesizing thiostrepton, a powerful antibiotic produced by certain bacteria.

23 Mar 2009

Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment

Metabolites are molecular fingerprints of what your cells are up to and Dr. Arun Sreekumar wants to know the impression made by cancer.

23 Mar 2009

Metabolites News and Research

New Category I CPT code for AspirinWorks Test Kit

Migraine can stimulate alcohol-induced headache

Blocking folic acid action during early pregnancy leads to increased risk of abnormalities in growing baby

Medications to reduce folic acid during pregnancy increase the risk of abnormalities in fetus

Research scientists develop bioengineered treatment for targeting pancreatic cancer

Research study to determine association of CYP2D6 variation with tamoxifen therapy

Central metabolic network model of Thermotoga maritima bacterium developed

Research program to study personalized medicine

Karo Bio receives US patent for its thyroid hormone receptor platform

PSC activation mechanisms help develop novel therapeutic approaches for pancreatic fibrosis

DDI Predict 2009 edition assessing the risk of potential drug-drug interactions released

Natural food compounds may play a vital role in cancer treatment

Researchers reveal that nonextractable polyphenols in fruits are a major part of bioactive compounds

Additional trial to be conducted for KYNAPID under FDA special protocol agreement

Special pathway makes bacteria vulnerable - new target for tailored antibiotics

Scientists shed new light on why pancreatic cancer drugs can fail

Key genetic mechanism a potential key to new class of antibiotics

New approach to prostate cancer detection - Sarcosine may distinguish between slow-growing and aggressive prostate cancers

Researchers identify genetic machinery responsible for synthesizing thiostrepton

Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment

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Why use light scattering to analyze proteins and viral vectors?

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