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Researchers identify potential new drug target for treating Barth syndrome

In a Nature Metabolism paper published today, researchers from the University of Pittsburgh detail a potential new target and a small-molecule drug candidate for treating Barth syndrome, a rare, life-threatening and currently incurable genetic disease with devastating consequences.

23 Nov 2023

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

In Alzheimer's disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau.

22 Nov 2023

Mapping blood vessel network of the meniscus with high precision

Knee operations on the meniscus cartilage are a frequent procedure on a particularly complex part of the human body.

21 Nov 2023

Study provides the first national estimate of family caregivers' pain and arthritis experiences

Researchers from Weill Cornell Medicine provide the first national estimate of caregivers' pain and arthritis experiences that can limit their ability to perform necessary tasks while caring for older family members.

20 Nov 2023

US military says national security depends on ‘forever chemicals’

The Department of Defense relies on hundreds, if not thousands, of weapons and products such as uniforms, batteries, and microelectronics that contain PFAS, a family of chemicals linked to serious health conditions.

20 Nov 2023

Simple soap solution could be a game-changer in the fight against malaria

Could the solution to the decades-long battle against malaria be as simple as soap? In a new study published in PLOS Neglected Tropical Diseases, scientists at The University of Texas at El Paso have made a compelling case for it.

17 Nov 2023

Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy

Study discovers that coffee, especially its bioactive compounds like chlorogenic acids, can inhibit SARS-CoV-2 entry and reduce ACE2 and TMPRSS2 levels, indicating that coffee intake might be a potential dietary strategy for COVID-19 prevention.

16 Nov 2023

Researchers identify the role of iron in ocular toxoplasmosis

Researchers from Nagoya University Graduate School of Medicine have identified the role of iron in ocular toxoplasmosis (OT), a form of toxoplasmosis that causes blindness.

14 Nov 2023

Vegan diet with soy significantly reduces hot flashes in postmenopausal women

A low-fat vegan diet that includes soy fosters changes in the gut microbiome that decrease postmenopausal vasomotor symptoms, or hot flashes, overall by 95%, according to a new study by the Physicians Committee for Responsible Medicine.

14 Nov 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Psychedelic compounds such as psilocybin, a substance found in various mushroom species, are garnering more research support as novel treatments for psychiatric disorders, but questions remain concerning who they may help the most.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Pediatric viral threats surge in the 21st century: A call for One Health approach

Scoping review in "Pediatric Research" examines the rise of pediatric viral diseases in the 21st century and underscores the importance of a One Health approach, integrating human, animal, and ecosystem health, to combat these emerging and re-emerging infectious threats effectively.

9 Nov 2023

Open-science drug discovery campaign yields a wealth of data on SARS-CoV-2 main protease

Although the group's work has been freely available since its inception in March 2020, the COVID Moonshot Consortium is finally formally reporting their results.

9 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

Compound News and Research

Researchers identify potential new drug target for treating Barth syndrome

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

Mapping blood vessel network of the meniscus with high precision

Study provides the first national estimate of family caregivers' pain and arthritis experiences

US military says national security depends on ‘forever chemicals’

Simple soap solution could be a game-changer in the fight against malaria

Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy

Researchers identify the role of iron in ocular toxoplasmosis

Vegan diet with soy significantly reduces hot flashes in postmenopausal women

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Pediatric viral threats surge in the 21st century: A call for One Health approach

Open-science drug discovery campaign yields a wealth of data on SARS-CoV-2 main protease

Preclinical discovery could point the way toward better treatments for type 2 diabetes

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

Scientists discover kidney-friendly antifungal that evades resistance

Broccoli sprouts diet protects mice from Crohn's disease, study shows

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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