Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

Scientists computationally restore the potency of an antibody against SARS-CoV-2 Omicron subvariants

A team of researchers from the United States computationally modified the COV2-2130 monoclonal antibody to restore its neutralizing ability against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, while retaining efficacy against the Delta and wild-type strains.

27 Oct 2022

Exploring new therapeutic targets and biomarkers for neurodegenerative disorders

In this interview, Dr. Shebna Massey discusses neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and more. She also discusses and explores new therapeutic targets and biomarkers for these diseases.

From Sino Biological Inc. 26 Oct 2022

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

In a recent study posted to the medRxiv* preprint server, researchers in the United States assessed the efficiency of protection mediated by antibodies against symptomatic coronavirus disease 2019 (COVID-19) at low serum-neutralizing titers.

24 Oct 2022

Exploring SARS-CoV-2-associated endothelial dysfunction

A new study described the evidence, mechanisms, and therapies for endothelial dysfunction in coronavirus disease 2019 (COVID-19).

21 Oct 2022

Immune-suppressing drug reverses symptoms of delirium in mice

Investigators from the departments of Neurology, Neurosurgery, Psychiatry, Medicine, and Biomedical Sciences at Cedars-Sinai have shown that an immune-suppressing drug similar to one used to treat severe COVID-19 reversed symptoms of delirium in mice whose lungs were injured during mechanical breathing assistance.

19 Oct 2022

Did the risk of severe COVID-19 in the immunodeficient population of the UK change following vaccination deployment?

Researchers evaluated the changing risk of severe COVID-19 outcomes in individuals with primary and secondary immunodeficiencies in the context of COVID-19 vaccinations.

17 Oct 2022

Omicron sublineage BA.2.75.2 largely resistant to several monoclonal antibody antiviral treatments

A study at Karolinska Institutet in Sweden shows that the coronavirus variant BA.2.75.2, an Omicron sublineage, largely evades neutralizing antibodies in the blood and is resistant to several monoclonal antibody antiviral treatments.

14 Oct 2022

Study determines how fibroblasts play a role in tumor's ability to generate anti-HER2 therapy resistance

A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar) has determined the role that fibroblasts, the cells that contribute to tissue formation, play in a tumor's ability to generate resistance to the most common biological treatment for HER2.

14 Oct 2022

Will covid spike again this fall? 6 tips to help you stay safe

Last year, the emergence of the highly transmissible omicron variant of the covid-19 virus caught many people by surprise and led to a surge in cases that overwhelmed hospitals and drove up fatalities. Now we're learning that omicron is mutating to better evade the immune system.

14 Oct 2022

Cat allergen immunotherapy works better and more quickly when combined with monoclonal antibody

An experimental approach to enhancing a standard cat allergy treatment made it more effective and faster acting, and the benefits persisted for a year after treatment ended, a study supported by the National Institutes of Health has found.

11 Oct 2022

The duration of the infectious stage of individuals infected with the SARS-CoV-2 Omicron variant

Researchers demonstrated clinical features and infectivity of the currently dominant SARS-CoV-2 variant of concern Omicron, compared to Delta, the previously dominant VOC.

3 Oct 2022

Universal vaccine advancement through AI and recombinant technology

In this interview, News-Medical talks to Dr. Amy Sheng and Dr. Lurong Pan about how AI computing can be used in combination with high throughput production and screening to enhance the development process for potential universal vaccines.

From Sino Biological Inc. 3 Oct 2022

Houston Methodist researchers receive CPRIT funding to research two of the most lethal cancers

Two Houston Methodist cancer researchers have been awarded a half million dollars in funding from the Cancer Prevention and Research Institute of Texas to further research two of the most lethal, difficult-to-treat cancers that all-too-often have poor prognoses.

28 Sep 2022

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

Study finds remdesivir-resistant version of COVID-19 in renal transplant recipients

Recent studies have shown that patients with weakened immune systems—which enables the virus that causes COVID-19 to remain longer in the body, copy itself, and continually change—may enable the development of new, slightly different versions of the virus (variants).

26 Sep 2022

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

In a new study, researchers demonstrated how sarbecovirus family down-regulates major histocompatibility complex-I (MHC-I) surface expression to evade cellular immunity.

26 Sep 2022

Common germline variants of APOE contribute to differential COVID-19 outcomes

Researchers investigated the relationship between APOE4 genotype and COVID-19 outcomes using genetic models of mice.

26 Sep 2022

Stanford Medicine study shows SARS-CoV-2 can infect human fat tissue

Is SARS-CoV-2 hiding in your fat cells? A study by Stanford Medicine investigators shows that SARS-CoV-2 can infect human fat tissue.

22 Sep 2022

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

In a recent study published in the journal PNAS, researchers from Finland and the United States reported a novel heptad repeat 2 (HR2) peptide that inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) without any chemical modifications.

21 Sep 2022

Study reveals increased immunity evasion by Omicron BA.2.75.2

In a recent study posted to the bioRxiv* preprint server, researchers from ETH Zurich, Imperial College London, and Karolinska Institutet identified increased resistance to antibody-mediated neutralization by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineage BA.2.75.2.

21 Sep 2022

Monoclonal Antibody News and Research

Further Reading

Scientists computationally restore the potency of an antibody against SARS-CoV-2 Omicron subvariants

Exploring new therapeutic targets and biomarkers for neurodegenerative disorders

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

Exploring SARS-CoV-2-associated endothelial dysfunction

Immune-suppressing drug reverses symptoms of delirium in mice

Did the risk of severe COVID-19 in the immunodeficient population of the UK change following vaccination deployment?

Omicron sublineage BA.2.75.2 largely resistant to several monoclonal antibody antiviral treatments

Study determines how fibroblasts play a role in tumor's ability to generate anti-HER2 therapy resistance

Will covid spike again this fall? 6 tips to help you stay safe

Cat allergen immunotherapy works better and more quickly when combined with monoclonal antibody

The duration of the infectious stage of individuals infected with the SARS-CoV-2 Omicron variant

Universal vaccine advancement through AI and recombinant technology

Houston Methodist researchers receive CPRIT funding to research two of the most lethal cancers

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Study finds remdesivir-resistant version of COVID-19 in renal transplant recipients

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

Common germline variants of APOE contribute to differential COVID-19 outcomes

Stanford Medicine study shows SARS-CoV-2 can infect human fat tissue

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

Study reveals increased immunity evasion by Omicron BA.2.75.2

Monoclonal Antibody Manufacturing Trends eBook eBook

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Changing the landscape of R&D to build clinical success from the ground up

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