Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

Key neural system at risk from prenatal exposure to alcohol

In a study of adult monkeys who were exposed to moderate amounts of alcohol in utero, scientists have found that prenatal exposure to alcohol - even in small doses - has pronounced effects on the development and function later in life of the brain's dopamine system, a critical component of the central nervous system that regulates many regions of the brain.

21 Sep 2005

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Mayo Clinic researchers in collaboration with scientists at Perlegen Sciences, Inc. and funded by the Michael J. Fox Foundation for Parkinson's Research have produced the first large-scale whole genome map of genetic variability associated with Parkinson's disease.

19 Sep 2005

Genetic basis for susceptibility to alcohol abuse confirmed

A new set of experiments in mice confirms that a brain receptor associated with the reinforcing effects of marijuana also helps to stimulate the rewarding and pleasurable effects of alcohol.

12 Sep 2005

Genetic makeup may detemine likely success of quit smoking therapies

A study by researchers at the Transdisciplinary Tobacco Use Research Center (TTURC) of the University of Pennsylvania School of Medicine indicates that a smoker's genetic make-up may affect whether they quit or not while using either bupropion (Zyban) or nicotine replacement therapies (NRTs) such as the nicotine patch or nasal spray.

30 Aug 2005

Benefits of MAO-B inhibitors are small but may be worthwhile in some patients with early Parkinson's disease

A class of drugs known as MAO-B inhibitors may be effective in improving motor symptoms in people with early Parkinson's disease and may delay the need for treatment with other drugs, according to a new systematic review of current evidence.

23 Aug 2005

Rotenone study may lead to novel therapies for Parkinson's disease

Neuroscientists from the University at Buffalo have described for the first time how rotenone, an environmental toxin linked specifically to Parkinson's disease, selectively destroys the neurons that produce dopamine, the neurotransmitter critical to body movement and muscle control.

23 Aug 2005

New insight into the neural computational function represented by "error-related negativity"

Deciphering the subtle, complex electrical signals emanating from the brain has yielded important insights into the still-mysterious neural mechanisms that underlie behavior.

18 Aug 2005

MDMA/Ectasy could lead to new treatments for Parkinson's disease

Researchers at Duke University have revealed new clues about Parkinson's disease which might one day lead to new treatments.

4 Aug 2005

New study aims to understand the intricate biochemistry governing gene regulation

In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems.

4 Aug 2005

Research to investigate new drug for Parkinsons disease

Researchers at the University of Sydney have received a grant to investigate the potential of a new drug to treat the abnormal posture and balance that affects people with Parkinson's disease ultimately confining them to a wheelchair.

2 Aug 2005

Drugs with similar chemical attributes as Ecstasy might offer useful alternatives to current therapies for Parkinson's disease

Amphetamines, including the drug popularly known as Ecstasy, can reverse the symptoms of Parkinson's disease in mice with an acute form of the condition, according to new research at Duke University Medical Center.

2 Aug 2005

Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties

A medication used to ease symptoms of amyotrophic lateral sclerosis, or Lou Gehrig's disease, also is helpful in treating people with treatment-resistant obsessive-compulsive disorder (OCD), according to a pilot study at Yale School of Medicine.

31 Jul 2005

Action of dopamine may be particularly important for understanding psychiatric conditions

Duke University Medical Center researchers have discovered a new mechanism by which chronically high levels of the neurotransmitter dopamine exert their effects on the brain.

28 Jul 2005

First trial of pramipexole for the treatment of fibromyalgia

The mechanism of fibromyalgia, a chronic illness characterized by muscle pain, fatigue, and sleep disturbances, is unknown and medications used to treat it (such as antidepressants, antiepileptics, muscle relaxants, antiinflammatories, sedative hypnotics, pain relievers and nutriceuticals) have had limited success.

28 Jul 2005

Methamphetamine users show symptoms similar to brain injury patients

Because today's methamphetamine is stronger, more potent and wreaks greater havoc on the brain, chronic users exhibit symptoms similar to patients with traumatic brain injury (TBI), according to the Brain Injury Association of Arizona (BIAAZ).

26 Jul 2005

Dopamine plays critical role in the modulation of sleep, wake, and arousal states

Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too.

12 Jul 2005

Gambling and sex addiction caused by Parkinson's drug

According to a doctor at a clinic in the U.S., a certain category of drug, which is often prescribed for Parkinson's disease, can cause some patients to become compulsive gamblers or addicted to sex.

11 Jul 2005

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Just why those with anorexia nervosa are driven to be excessively thin and seem unaware of the seriousness of their condition could be due to over-activity of a chemical system found in a region deep inside the brain, a University of Pittsburgh study suggests.

11 Jul 2005

Dopamine agonist therapy for Parkinson's disease may lead to problem gambling

Eleven patients with Parkinson's disease (PD) developed pathological gambling behavior following dopamine agonist therapy, a drug therapy to control movement problems caused by Parkinson's disease, according to a study posted online which will appear in the September print issue of Archives of Neurology.

11 Jul 2005

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

Analysis of the brain of a patient suffering from Parkinson's Disease has shown that the experimental treatment he received caused regrowth of the nerve fibres that are lost in this disease. The findings are reported in the July issue of Nature Medicine.

6 Jul 2005

Dopamine News and Research

Further Reading

Key neural system at risk from prenatal exposure to alcohol

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Genetic basis for susceptibility to alcohol abuse confirmed

Genetic makeup may detemine likely success of quit smoking therapies

Benefits of MAO-B inhibitors are small but may be worthwhile in some patients with early Parkinson's disease

Rotenone study may lead to novel therapies for Parkinson's disease

New insight into the neural computational function represented by "error-related negativity"

MDMA/Ectasy could lead to new treatments for Parkinson's disease

New study aims to understand the intricate biochemistry governing gene regulation

Research to investigate new drug for Parkinsons disease

Drugs with similar chemical attributes as Ecstasy might offer useful alternatives to current therapies for Parkinson's disease

Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties

Action of dopamine may be particularly important for understanding psychiatric conditions

First trial of pramipexole for the treatment of fibromyalgia

Methamphetamine users show symptoms similar to brain injury patients

Dopamine plays critical role in the modulation of sleep, wake, and arousal states

Gambling and sex addiction caused by Parkinson's drug

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Dopamine agonist therapy for Parkinson's disease may lead to problem gambling

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

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