Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

New MIT technology may help make cancer biomarker detection much easier

Finding ways to diagnose cancer earlier could greatly improve the chances of survival for many patients. One way to do this is to look for specific proteins secreted by cancer cells, which circulate in the bloodstream. However, the quantity of these biomarkers is so low that detecting them has proven difficult.

17 Dec 2012

American Thoracic Society, IASLC and ERS propose new sub-classification of lung adenocarcinomas

The International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS), have proposed a new sub-classification of lung adenocarcinomas.

16 Dec 2012

Study describes new, paradoxical characteristics of HER2-negative breast cancer

A multicenter study led by researchers at UC Davis describes new, paradoxical characteristics of the most common type of breast cancer. The findings shed light on how the disease can evade treatment and could improve diagnosis and treatment of breast cancer.

15 Dec 2012

Bayer files radium-223 NDA with FDA for treatment of CRPC patients with bone metastases

Bayer HealthCare today announced that the company has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval for radium Ra 223 dichloride (radium-223), an investigational compound for the treatment of castration-resistant prostate cancer (CRPC) patients with bone metastases.

15 Dec 2012

Predictor of lymph node metastasis after oral cancer unmasked

The presence of high levels of tumor-associated tissue eosinophilia in early oral squamous cell carcinoma tissue can predict future occult lymph node metastasis, study results show.

13 Dec 2012

U-M devises new system to capture and study circulating tumor cells

A glass plate with a nanoscale roughness could be a simple way for scientists to capture and study the circulating tumor cells that carry cancer around the body through the bloodstream.

12 Dec 2012

Celldex announces final results from CDX-011 Phase 2b study on GPNMB-expressing breast cancer

Celldex Therapeutics, Inc. today announced final results from the Company's randomized Phase 2b EMERGE study of CDX-011 in patients with glycoprotein NMB (GPNMB)-expressing, advanced, heavily pretreated breast cancer.

9 Dec 2012

Genomic tests increase accuracy of breast cancer diagnosis

The latest generation of genomic tests for breast cancer can improve physicians' ability to diagnose the disease and more precisely tailor each patient's treatment, according to a study being presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium (SABCS). The study examined the first commercially available genomic tests to determine the molecular subtype of a breast cancer tumor.

7 Dec 2012

Researchers discover 29 proteins associated with spread of kidney cancer

Researchers at St. Michael's hospital have identified 29 proteins that are likely to be involved in the spread of kidney cancer. The discovery will help physicians recognize which tumours are going to behave more aggressively and provide those patients with more intensive treatment and closer followup.

7 Dec 2012

Bio-Path to initiate BP-100-1.01 Phase I trial for treatment of two types of breast cancer

Bio-Path Holdings, Inc., a biotechnology company developing a liposomal delivery technology for nucleic acid cancer drugs, today announced it is initiating development of its lead cancer drug BP-100-1.01 (Liposomal Grb-2) to treat triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC), two cancers characterized by formation of aggressive tumors and relatively high mortality rates.

6 Dec 2012

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

6 Dec 2012

Researchers investigate GPER receptor as possible new drug target for breast cancer

Five-year breast cancer survival rates have improved dramatically over the past 50 years, but tumors can recur up to ten or more years after they are detected. When tumors recur, they are even more difficult to treat.

5 Dec 2012

NOXXON commences NOX-H94 Phase IIa trial to treat anemia of chronic disease

NOXXON Pharma today announced the treatment of the first patients in a Phase IIa clinical trial of its anti-hepcidin Spiegelmer NOX-H94 to treat anemia associated with chronic disease.

5 Dec 2012

Prrx1 component prevents cancer cells from lodging in other organs

Researchers discover that the cellular component Prrx1 prevents cancer cells from lodging in other organs and, therefore, generating new focuses of cancer.

3 Dec 2012

Study shows how cancer cells control ON/OFF switch of EMT program

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, has shown for the first time how cancer cells control the ON/OFF switch of a program used by developing embryos to effectively metastasize in vivo, breaking free and spreading to other parts of the body, where they can proliferate and grow into secondary tumors.

30 Nov 2012

Wichita State professor hopes to understand how cancer cells spread and become fatal

Through her research at Wichita State University, assistant chemistry professor Moriah Beck hopes to understand how cancer cells spread and become fatal.

30 Nov 2012

Fn14 gene plays a role in growth and spread of non-small cell lung cancer tumors

Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options.

30 Nov 2012

Exelixis announces FDA approval of COMETRIQ for treatment of medullary thyroid cancer

Exelixis, Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved COMETRIQ (cabozantinib) for the treatment of progressive, metastatic medullary thyroid cancer (MTC).

30 Nov 2012

Varian's TrueBeam receives Indian AERB clearance for use in advanced radiosurgical treatments

Varian Medical Systems has received regulatory clearance from the Indian Atomic Energy Regulatory Board for the use of its unique TrueBeam High Intensity Mode for advanced radiosurgical treatments.

29 Nov 2012

European Medicines Agency accepts Exelixis’ COMETRIQ MAA for review

Exelixis, Inc. today announced the European Medicines Agency (EMA) has accepted for review the Marketing Authorization Application (MAA) for COMETRIQ (cabozantinib) for the proposed indication of treatment of progressive, unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC).

29 Nov 2012

Metastasis News and Research

Further Reading

New MIT technology may help make cancer biomarker detection much easier

American Thoracic Society, IASLC and ERS propose new sub-classification of lung adenocarcinomas

Study describes new, paradoxical characteristics of HER2-negative breast cancer

Bayer files radium-223 NDA with FDA for treatment of CRPC patients with bone metastases

Predictor of lymph node metastasis after oral cancer unmasked

U-M devises new system to capture and study circulating tumor cells

Celldex announces final results from CDX-011 Phase 2b study on GPNMB-expressing breast cancer

Genomic tests increase accuracy of breast cancer diagnosis

Researchers discover 29 proteins associated with spread of kidney cancer

Bio-Path to initiate BP-100-1.01 Phase I trial for treatment of two types of breast cancer

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Researchers investigate GPER receptor as possible new drug target for breast cancer

NOXXON commences NOX-H94 Phase IIa trial to treat anemia of chronic disease

Prrx1 component prevents cancer cells from lodging in other organs

Study shows how cancer cells control ON/OFF switch of EMT program

Wichita State professor hopes to understand how cancer cells spread and become fatal

Fn14 gene plays a role in growth and spread of non-small cell lung cancer tumors

Exelixis announces FDA approval of COMETRIQ for treatment of medullary thyroid cancer

Varian's TrueBeam receives Indian AERB clearance for use in advanced radiosurgical treatments

European Medicines Agency accepts Exelixis’ COMETRIQ MAA for review

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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