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Antifungal agent Itraconazole inhibits SARS CoV-2 in vitro

Itraconazole is a broad-spectrum antifungal agent that has been shown to have some in vitro activity against SARS-CoV-2 by a team of Belgian and German researchers.

16 Nov 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Life Sciences Mass Spectrometry 16 Nov 2020

New saliva-based test found to accurately detect the presence of SARS-CoV-2 antibodies

A new saliva-based test developed by a team at Johns Hopkins Bloomberg School of Public Health has been found to accurately detect the presence of antibodies to SARS-CoV-2, the virus that causes COVID-19, from small samples of saliva, according to a study led by Bloomberg School researchers.

15 Nov 2020

High prevalence of cross-reactive anti-SARS-CoV-2 antibodies in sub-Saharan Africa

A recent study published in the International Journal of Infectious Diseases has explained the lower prevalence of coronavirus disease 2019 (COVID-19) in sub-Saharan Africa compared to that in the US, Europe, and Asia.

15 Nov 2020

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – has already infected over 52 million people worldwide, and has subsequently claimed over 1.3 million lives. However, among the innumerable promising drug candidates that help battle the virus and mitigate its damage, none have yet made it to the clinic.

12 Nov 2020

"Cat's claw" extract inhibits replication of SARS-CoV-2 in vitro

Researchers in Columbia and Peru have shown that Uncaria tomentosa – a woody vine native to South America known of as "Cat's claw" – exerts in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

12 Nov 2020

StemBioSys and Cartox Announce Publication of Research Demonstrating CELLvo™ Matrix Plus Significantly Enhances the Functionality of hiPSC Cardiomyocytes

StemBioSys, Inc announced today the publication of research in Nature Scientific Reports demonstrating their latest CELLvo™ Matrix Plus findings.

From StemBioSys 12 Nov 2020

Beckman Coulter introduces new SARS-CoV-2 IgM assay in countries accepting the CE Mark

Beckman Coulter, a clinical diagnostics leader, today announced the launch of its Access SARS-CoV-2 Immunoglobulin M assay in countries accepting the CE Mark.

From Beckman Coulter Diagnostics 12 Nov 2020

Researchers identify acrylamides that inhibit SARS-CoV-2 main protease

A new study in the preprint server bioRxiv published in November 2020 describes the discovery of acrylamide fragments that can effectively disable key enzymes in both the hand, foot and mouth virus and SARS-CoV-2 virus.

11 Nov 2020

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

A study conducted at the United States Army Research Institute of Infectious Diseases shows how a relatively simple full-length DNA vaccine against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit neutralizing antibody response in an animal model – even after a single shot with simple jet injection technique.

11 Nov 2020

Research tracks humoral immunity response over eight months post COVID-19 infection

Researchers from Chongqing Medical University have tried to answer one of the burning questions regarding the longevity of immune response to coronavirus disease 2019 (COVID-19): How long does immunity last after infection? Their study looked at the lasting effects and continued immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over eight months after recovery from the infection.

11 Nov 2020

Critically ill COVID-19 patients experience novel platelet-activating immune complexes, study finds

Canadian researchers from McMaster University, Ontario, have pinpointed platelet activating immune complexes in coagulation disorders associated with coronavirus disease 2019 (COVID-19), the condition caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

10 Nov 2020

New three-step approach promises to improve COVID-19 testing accuracy

One critical barrier in efforts to control the COVID-19 pandemic has been the relatively high false-negative rate of the most commonly-used Reverse Transcription Polymerase Chain Reaction (RT-PCR) testing methods.

10 Nov 2020

Researchers discover unique anti-cancer function for previously well-characterized protein

The development and progression of cancer is a complicated process that occurs when cells in the body grow out of control. Many different mechanisms and pathways that directly affect cell proliferation have been uncovered.

10 Nov 2020

Lateral flow test enables faster, accurate diagnosis of periprosthetic joint infection

The recently FDA-authorized alpha-defensin lateral flow test is a highly accurate, ten-minute test for diagnosis of periprosthetic joint infection (PJI) - a serious and costly complication of total joint replacement, reports a study in The Journal of Bone & Joint Surgery.

9 Nov 2020

Study suggests herd immunity to COVID-19 in New York City is low

Researchers in the United States have estimated that the proportion of people in New York City who developed antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first wave of the coronavirus disease 2019 (COVID-19) pandemic is around one in eight.

9 Nov 2020

Promising yeast-expressed SARS-CoV-2 vaccine candidate effective in mice

Researchers at the Texas Children's Hospital Center for Vaccine Development, USA, have published a report on the preprint server bioRxiv that describes a yeast-expressed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) protein, a key target of current vaccine development efforts.

9 Nov 2020

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Researchers at the Francis Crick Institute and University College London have found that some antibodies, created by the immune system during infection with common cold coronaviruses, can also target SARS-CoV-2 and may confer a degree of protection against the new viral strain.

9 Nov 2020

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

In a recent groundbreaking study, researchers from Stanford University demonstrated the potential of multiplexed targeted next-generation sequencing assay for detecting SARS-CoV-2 genetic fingerprints used in mutation profiling, with the potential of massive scalability required for population studies. The findings are currently available on the medRxiv preprint server.

8 Nov 2020

Study shows SARS-CoV-2 infection four times more likely through household transmission than community

A group of researchers from across the United States working in collaboration with their Swiss counterparts have conducted an extensive population-based serological survey to understand the transmission dynamics of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) – the novel agent that causes coronavirus disease 2019 (COVID-19).

8 Nov 2020

Assay News and Research

Antifungal agent Itraconazole inhibits SARS CoV-2 in vitro

Affinity-Bead Assisted Mass Spectrometry for Proteomics

New saliva-based test found to accurately detect the presence of SARS-CoV-2 antibodies

High prevalence of cross-reactive anti-SARS-CoV-2 antibodies in sub-Saharan Africa

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

"Cat's claw" extract inhibits replication of SARS-CoV-2 in vitro

StemBioSys and Cartox Announce Publication of Research Demonstrating CELLvo™ Matrix Plus Significantly Enhances the Functionality of hiPSC Cardiomyocytes

Beckman Coulter introduces new SARS-CoV-2 IgM assay in countries accepting the CE Mark

Researchers identify acrylamides that inhibit SARS-CoV-2 main protease

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

Research tracks humoral immunity response over eight months post COVID-19 infection

Critically ill COVID-19 patients experience novel platelet-activating immune complexes, study finds

New three-step approach promises to improve COVID-19 testing accuracy

Researchers discover unique anti-cancer function for previously well-characterized protein

Lateral flow test enables faster, accurate diagnosis of periprosthetic joint infection

Study suggests herd immunity to COVID-19 in New York City is low

Promising yeast-expressed SARS-CoV-2 vaccine candidate effective in mice

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

Study shows SARS-CoV-2 infection four times more likely through household transmission than community

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