Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Why some people do not respond as well as others to statin therapy

A newly discovered genetic variation, in combination with a second variation, reduces the ability of statin drugs to lower "bad" LDL cholesterol, researchers report at the American Heart Association's Scientific Sessions 2005.

20 Nov 2005

Trichostatin A may fight lupus and atherosclerosis simultaneously

People with lupus are prone to premature accelerated atherosclerosis. Now scientists at Wake Forest University School of Medicine think they have a way to prevent or decrease this atherosclerosis and prevent heart attacks.

16 Nov 2005

Edifoligide no better than placebo for clogged veins

A new drug, edifoligide, designed to prevent the clogging of veins used in coronary bypass surgery was no more effective than a placebo, according to the results of a Phase III clinical trial led by researchers at Duke Clinical Research Institute (DCRI).

14 Nov 2005

New understanding of the disease process involved in atherosclerosis

The progression of the artery-clogging disease atherosclerosis is linked to the inability of specialized bone marrow cells to continuously repair damage to the arterial lining, Duke University Medical Center researchers have demonstrated.

13 Nov 2005

Phenolic compounds in olive oil may explain cardiovascular health benefits associated with Mediterranean Diet

Phenolic compounds in olive oil, which have antioxidant, anti-inflammatory and anti-clotting properties, may explain cardiovascular health benefits associated with the so-called Mediterranean Diet, according to a new study in the Nov. 15, 2005, issue of the Journal of the American College of Cardiology.

13 Nov 2005

Pretreating a vein graft with edifoligide prior to coronary bypass graft surgery does not lower the rate of graft failure

Coronary artery bypass graft (CABG) surgery is one of the most common surgical procedures performed in the United States, according to background information in the article. In appropriately selected patients, CABG surgery results in improved survival, relief of angina, and improved quality of life. Despite frequent use of artery grafts, vein grafts remain the most frequently used conduit.

13 Nov 2005

Diabetic black men have lower amounts of atherosclerosis than diabetic white men

In a surprising outcome, investigators at Wake Forest University Baptist Medical Center found that diabetic black men have dramatically lower amounts of atherosclerosis, or hardening of the arteries, than diabetic white men.

3 Nov 2005

Important breakthrough in developing the drugs of the future

Their work on targeting individual genes for more effective and cheaper drug testing opens the way to treatments for a huge range of diseases including diabetes and atherosclerosis, which leads to strokes and heart attacks.

3 Nov 2005

Growth patterns before birth, after birth and into childhood reveal a risk of coronary heart disease later in life

The risk of developing coronary heart disease as an adult is more strongly related to childhood growth patterns than body weight at any particular point in development, according to a new study published in the Oct. 27 New England Journal of Medicine. Coronary heart disease is the leading cause of death in the United States.

27 Oct 2005

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Carbon nanoparticles - both those unleashed in the air by engine exhaust and the engineered structures thought to have great potential in medical applications - promote blood-clotting, scientists report in an upcoming edition of the British Journal of Pharmacology.

23 Oct 2005

Significant step forward in the genome era

In what promises to be a significant step forward in the genome era, the National Human Genome Research Institute (NHGRI) today announced plans to devote a portion of its large-scale sequencing capacity to efforts aimed at identifying the genetic roots of specific diseases that have long eluded gene hunters.

17 Oct 2005

Erectile dysfunction may be a sign that coronary artery disease is developing

"We think that erectile dysfunction represents the 'tip of the iceberg' of a systemic vascular disorder; thus potentially preceding severe cardiovascular events. Erectile dysfunction should be part of a cardiovascular risk assessment.

11 Oct 2005

Cholesterol levels among older adults has declined significantly

The total cholesterol level among older adults has declined significantly, while there has been little change among younger adults, according to a study in the October 12 issue of JAMA: The Journal of the American Medical Association.

11 Oct 2005

Gleevec's uses might expand even further

Gleevec (Imatinib) is a representative of the newest generation of cancer drugs. The substance conveys its potent anti-proliferative effect by selectively supressing the tyrosine kinase pathway. The Giessen lung researchers now issue a first report of this substance as a new target therapy for pulmonary hypertension

4 Oct 2005

Mayo Clinic researchers find earliest sign of nerve change due to diabetes

Mayo Clinic researchers have found that subtle change in nerve conduction is the first reliable sign of nerve complications from diabetes and that this change can be measured long before other symptoms or signs of nerve damage develop.

3 Oct 2005

Flavanols help smokers repair blood vessel function

Phytochemicals known as flavanols, which are found in chocolate, fruits and vegetables, can boost the levels of nitric oxide in the blood of smokers and reverse some of their smoking-related impairment in blood vessel function, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Atherosclerosis News and Research

Further Reading

Why some people do not respond as well as others to statin therapy

Trichostatin A may fight lupus and atherosclerosis simultaneously

Edifoligide no better than placebo for clogged veins

New understanding of the disease process involved in atherosclerosis

Phenolic compounds in olive oil may explain cardiovascular health benefits associated with Mediterranean Diet

Pretreating a vein graft with edifoligide prior to coronary bypass graft surgery does not lower the rate of graft failure

Diabetic black men have lower amounts of atherosclerosis than diabetic white men

Important breakthrough in developing the drugs of the future

Growth patterns before birth, after birth and into childhood reveal a risk of coronary heart disease later in life

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Significant step forward in the genome era

Erectile dysfunction may be a sign that coronary artery disease is developing

Cholesterol levels among older adults has declined significantly

Gleevec's uses might expand even further

Mayo Clinic researchers find earliest sign of nerve change due to diabetes

Flavanols help smokers repair blood vessel function

C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance

The immune mechanisms of atherosclerosis

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Smoking may increase the risk of developing diabetes

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