Heart Defect News and Research

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Discovery of key genetic factors that drive the process of generating new heart cells

Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells.

26 Apr 2009

Mouse model provides a new tool for investigating Wolf-Hirschhorn syndrome

Wolf-Hirschhorn Syndrome (WHS) is a human disease caused by spontaneous genetic deletions.

22 Apr 2009

Vitamin E during pregnancy puts babies at risk of heart defects

New research by scientists in the Netherlands has found that vitamin E supplements taken during pregnancy can increase the risk of heart defects in babies.

13 Apr 2009

District Court decision received in Concerta patent sase

The U.S. District Court for the District of Delaware has rendered a decision in the patent litigation between Alza Corporation, McNeil-PPC, Inc. and Andrx Pharmaceuticals LLC. McNeil Pediatrics, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., which markets Concerta (methylphenidate HCI) Extended-Release Tablets CII, said the court held that the patent in suit is not valid or infringed by the filing of Andrx's Abbreviated New Drug Application.

1 Apr 2009

Environment plays role in hypoplastic left heart syndrome

A congenital heart disease that often leads to death in newborns is significantly more common during the summer, leading researchers to believe that the environment, and not just genes that affect the heart, may play a role in causing "mini-epidemics" of this disease.

30 Mar 2009

Gilead commences phase II trial of Cicletanine for pulmonary arterial hypertension

Gilead Sciences, Inc. has announced that it has begun enrolling patients in a Phase II clinical trial of cicletanine hydrochloride (cicletanine), an oral agent in development for the treatment of pulmonary arterial hypertension (PAH).

24 Mar 2009

Pulmonary hypertension in children may result from reduced activity of gene regulator

Too little activity by gene regulators called PPARs appears to be a major player in the irreversible lung damage that can occur in children with heart defects, researchers say.

5 Mar 2009

FDA clears new immune response claim for CryoValve SG pulmonary human heart valve

CryoLife, Inc. has announced that the U.S. Food and Drug Administration (FDA) has cleared a new claim for the CryoValve(R) SG pulmonary human heart valve.

18 Feb 2009

Obesity during pregnancy associated with increased risk of birth defects

For women who are obese during pregnancy there is an associated increased risk of certain birth defects, such as spina bifida and neural tube defects, although the absolute increase in risk is likely to be small, according to an analysis of previous studies, reported in the February 11 issue of JAMA.

10 Feb 2009

Researcher develops method to combat congenital heart disease in children

Congenital heart defects account for five times more deaths annually than all childhood cancers combined.

9 Feb 2009

Discovery of new syndrome associated with severe congenital neutropenia

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3).

5 Jan 2009

Trial of Gore-tex-type material to stop strokes

A study is under way at Rush University Medical Center using a small, soft-patch device made of a Gore-tex-type material - often used to make durable outerwear - to close a common hole found in the heart called a patent foramen ovale (PFO) in order to prevent recurrent strokes and transient ischemic attacks (TIAs) in adults.

18 Nov 2008

Racial disparities found in access and use of organ transplantation in children listed for heart transplant

Minority children awaiting a donor heart for transplant have a higher death rate than white children, even after controlling for clinical risk factors, according to research presented at the American Heart Association's Scientific Sessions 2008.

11 Nov 2008

Stem cells from umbilical cord blood may help build new heart valves

Children with heart defects may someday receive perfectly-matched new heart valves built using stem cells from their umbilical cord blood, according to research presented at the American Heart Association's Scientific Sessions 2008.

11 Nov 2008

Cardiopulmonary bypass for child heart surgery does not affect IQ

The use of cardiopulmonary bypass does not cause short-term neurological problems in children and teenagers after surgery for less complex heart defects, according to pediatric researchers.

11 Nov 2008

Researchers discover genetic basis for some common congenital birth defects

10 Nov 2008

Absence of ERK2 gene linked to birth defects

A multidisciplinary research team at Case Western Reserve University led by Gary Landreth, Ph.D., a professor in the School of Medicine's Department of Neurosciences, has uncovered a common genetic pathway for a number of birth defects that affect the development of the heart and head. Abnormal development of the jaw, palate, brain and heart are relatively common congenital defects and frequently arise due to genetic errors that affect a key developmental pathway.

10 Nov 2008

Medtronic announces U.S. trial data on transcatheter valve for congenital heart disease

Today at the annual scientific sessions of the American Heart Association, the first U.S. clinical trial data on the Melody transcatheter pulmonary valve were presented. These findings also represent the first U.S. data on transcatheter valves in a population with congenital heart disease and the first reported U.S. data on the use of a transcatheter valve in the pulmonary position. The Melody valve is currently investigational in the U.S.

10 Nov 2008

New guidelines for congenital heart disease

These days most children born with congenital heart disease live well into adulthood, thanks to innovative surgical, interventional and medical treatments.

8 Nov 2008

How the Nodal gene family keeps the heart in the right (asymmetric) place

Asymmetry is crucial for the heart proper functioning, and now, scientists from the Institute Gulbenkian of Science in Portugal and Harvard University, have discovered that a family of genes, called Nodal, is crucial determining this asymmetry by controlling the speed and direction of the heart muscle cells during embryonic development.

2 Nov 2008