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Novel FIMP protein may help orchestrate mammalian fertilization

Fertilization is a fundamental process in sexual reproduction when the combination of male and female gametes blends genetic material to create a new unique individual. Now, researchers from Japan have identified a new factor that may help orchestrate this vitally complex life event.

16 Apr 2020

Horizon Discovery offers rapid access to CHOSOURCE platform for development of COVID-19 therapies

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation for cell line engineering, today announced special commercial licensing terms to facilitate rapid access to its cGMP-compliant CHOSOURCE platform for the development or production of therapeutic proteins, diagnostic assay components or vaccines relating to COVID-19.

16 Apr 2020

'Chaperone protein' protects against autoimmune diseases, mice study shows

Like a parent of teenagers at a party, Mother Nature depends on chaperones to keep one of her charges, the immune system, in line so that it doesn't mistakenly attack normal cells, tissues and organs in our bodies.

15 Apr 2020

Researchers discover inflammatory mechanism that contributes to autoimmune diseases

The protein STING (Stimulator of Interferon Genes) is a critical component of the body's innate immune defence system, but can also contribute to chronic autoimmune and autoinflammatory diseases.

8 Apr 2020

Horizon Discovery expands cell-based CRISPR screening services

Horizon Discovery Group plc, today announced the addition of an arrayed CRISPR knockout screening service for primary human B cells.

From Revvity 6 Apr 2020

GABA is a key regulator to metamorphosis, shows study

Metamorphosis, or a dramatic change in physical appearance, is a normal part of the life cycle of many animals, carried out to take advantage of different ecological niches.

1 Apr 2020

Finding new treatments for muscular dystrophy with CRISPR-Cas9

A new study out of Boston's Children's Hospital has used the gene-editing tool CRISPR-Cas9 to explore the fatal genetic condition called facioscapulohumeral dystrophy (FSHD, one of the family of muscular dystrophies), and to test out the potential utility of various genes involved in this disorder. The research is published in the journal Science Translational Medicine.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Study identifies brake on immune activity raising new possibilities for anticancer therapy

The immune system is like a carefully regulated machine, complete with its own built-in "brakes" that prevent it from overreacting and causing excess inflammation in otherwise healthy tissues.

25 Mar 2020

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

BIN1 deficit leads to impaired spatial learning and memory

Bridging integrator 1, known as BIN1, is the second most common risk factor for late-onset Alzheimer's disease, according to genome-wide studies of genetic variants. Yet, scientists know little about what this protein does in the brain.

11 Mar 2020

Gene therapy reverses cardiac dysfunction in mice with Barth syndrome

Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth.

9 Mar 2020

Researchers uncover novel neurotransmitter system in the brain

Neurotransmitters are chemicals that transmit signals between neurons or from neurons to other cells. They interact with specific receptors found in the brain of humans and animals, controlling a variety of biological processes, e.g. fear, anger, pleasure, memory, energy, appetite and sleep.

5 Mar 2020