Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

8 Mar 2022

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

A recent study reported that monocytosis during the acute phase of coronavirus disease 2019 could forecast anosognosia in long COVID.

8 Mar 2022

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Investigators have discovered that a biodegradable nanoparticle used in medical sutures could combat a rare, sometimes-fatal autoimmune disease.

7 Mar 2022

Severity-dependent immune mechanisms in the cerebrospinal fluid and plasma of COVID-19 patients

Researchers determined the immune mechanisms associated with severe neurological manifestations of COVID-19.

7 Mar 2022

Study establishes that a low dose SARS-CoV-2 infection increases risk of pneumococcal coinfection

A new study published on the bioRxiv* preprint server has evaluated bacterial susceptibility during SARS-CoV-2 infection.

3 Mar 2022

Dual therapeutic potential of zapnometinib against COVID-19

Researchers assessed the impact of the drug zapnometinib on human immune response against coronavirus disease 2019.

2 Mar 2022

Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

Researchers conducted a comprehensive and systematic analysis of functional SARS-CoV-2 antibody profiles in a controlled randomized trial of severe COVID-19 hospitalized individuals treated with COVID-19 CCP.

25 Feb 2022

Melatonin as a safe and potentially life-saving treatment for COVID-19

A new study discusses the possible role of melatonin, an antioxidant and anti-inflammatory agent, in treating COVID-19.

24 Feb 2022

Foundational characterization of a new bat-borne ebolavirus and its potential as a human pathogen

Researchers sought to evaluate the zoonotic potential of BOMV to assess the level of risk to public health.

24 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Mouse-adapted virus model to study persistent COVID induced lung disease

Researchers develop a mouse model to identify early biomarkers and test countermeasures needed to detect and prevent PASC.

21 Feb 2022

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

More than 50,000 bone marrow-derived stem cell transplants are performed worldwide each year to treat a wide range of conditions, including brain diseases.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ARDS, often resulting in the death of severely ill COVID-19 patients.

21 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Macrophage News and Research

Further Reading

Whole-genome sequencing for determination of factors associated with critical COVID-19

Relationship between immunological responses in the acute phase of SARS-CoV-2 infection and long-term cognitive deficits

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Severity-dependent immune mechanisms in the cerebrospinal fluid and plasma of COVID-19 patients

Study establishes that a low dose SARS-CoV-2 infection increases risk of pneumococcal coinfection

Dual therapeutic potential of zapnometinib against COVID-19

Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

Melatonin as a safe and potentially life-saving treatment for COVID-19

Foundational characterization of a new bat-borne ebolavirus and its potential as a human pathogen

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Mouse-adapted virus model to study persistent COVID induced lung disease

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

mRNA COVID-19 vaccine shown to induce afucosylated antibodies in individuals without prior SARS-CoV-2 exposure

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

Circadian cycle controls the brain's ability to clear a protein linked to Alzheimer's disease

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Study shows how gut bacteria could undermine immunity in pancreatic cancer

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