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Researchers develop safe, potent mRNA vaccine adjuvants that can elicit effective immune response

Production of conventional vaccines, which involves the use of live-attenuated or purified protein subunits of pathogens, is a long and complex process. Nucleic acid vaccines are safer alternatives, and allow easy adjustment of antigen to target specific pathogens.

9 Feb 2018

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

A group of Brazilian scientists achieved promising results using isolated compounds from the venom of the South American rattlesnake in combat of hepatitis C.

8 Feb 2018

Researchers describe human blood-nerve barrier transcriptome for the first time

Human peripheral nerves -- all the nerves outside of the central nervous system -- are protected by the blood-nerve barrier. This is a tight covering of endothelial cells that maintains the microenvironment within the nerves by restricting the amounts or types of water, ions, solutes and nutrients that can reach the axons, or electric cables within the nerves, from the blood circulation system.

8 Feb 2018

First drug-candidate compounds discovered using AI licensed for development

Insilico Medicine, Inc., a Baltimore-based next-generation artificial intelligence company specializing in the application of deep learning for drug discovery, announces that Juvenescence.AI, its joint venture with Juvenescence Limited, has licensed its first compound family for clinical development.

7 Feb 2018

Researchers reveal promising method for delivering cancer virotherapy

Researchers at Okayama University report in Scientific Reports a promising method for delivering viral DNA, able to eliminate cancerous cells, to a tumor. The approach, involving encapsulation of the DNA in liposomes, has the potential to enable intravenous delivery of virus-based antitumor agents.

6 Feb 2018

Researchers uncover novel therapeutic target for type 2 diabetes

Researchers from Kanazawa University and the National Center for Global Health and Medicine in Tokyo report, in Nature Communications, a new mechanism for regulating glucose uptake by the liver which has implications for type 2 diabetes and its treatment.

6 Feb 2018

Researchers receive major boost to explore long-standing paradigm in endocrinology

A team of researchers at the University of California, Riverside, seeking to upend a long-held theory explaining how hormones freely enter and exit cells, has received a major boost in the form of a $1 million award from the W. M. Keck Foundation.

5 Feb 2018

Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Microcephaly, brain calcification, skeletal alterations, auditory and visual deficits - these are examples of the damage that can be caused by Zika virus in babies born to mothers infected during pregnancy.

2 Feb 2018

Geneva researchers highlight new way to control tumor progression

For a tumor to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumor vascularization is therefore an interesting anti-tumor therapy that has been explored over the last ten years.

2 Feb 2018

Eating a Mediterranean diet may increase IVF success, finds study

A recent study found that women who consume a Mediterranean diet six months before undergoing IVF are more likely to conceive successfully.

1 Feb 2018

Researchers develop new magnet-based method for delivering drugs directly to cancerous tissues

A team of researchers at the University of Georgia has developed a non-invasive method of delivering drugs directly to cancerous tissue using magnetic forces, a form of treatment that could significantly reduce the toxic side effects of chemotherapy.

1 Feb 2018

New organ-on-a-chip technology provides simple setting to study blood vessel formation

Researchers at the Institute of Industrial Science, the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting this event.

31 Jan 2018

Study paves new way for development of vaccines against epidemics

The search for vaccines, treatments and preventive methods against infection by emerging viruses is one of the major challenges of global epidemiology.

30 Jan 2018

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Spinocerebellar ataxia is a group of neurodegenerative diseases characterized by progressive incoordination of gait, and is often associated with poor coordination of hands, speech, and eye movements.

27 Jan 2018

Eagle Biosciences launches novel Intact FGF23 ELISA Assay Kit

Eagle Biosciences, Inc. is proud to announce the launch of a new assay, MedFrontier FGF23 (Human Intact FGF23) ELISA Assay Kit. This assay was developed and manufactured by Kyowa Medex Co., Ltd from Tokyo, Japan.

27 Jan 2018

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

Abnormalities in glucose uptake by the liver (or hepatic glucose uptake; HGU) cause elevations in blood glucose levels following meals, a state that is known as postprandial hyperglycemia.

27 Jan 2018

Biotechnology startup receives FDA clearance for synthetic bone graft substitute

A biotechnology startup enabled by UC Davis, Molecular Matrix Inc., has received Food and Drug Administration clearance for a carbohydrate-based polymer that can help injured bones heal and regrow.

27 Jan 2018

Scientists imitate the Human Blood-retinal barrier on a microfluidic chip

For years scientists have sought to minimise Animal testing and speed up clinical trials. One alternative is the use of in vitro assays using live cells, but its effectiveness is limited, since it is difficult to reproduce interaction and interconnection between cells.

24 Jan 2018

BIST researchers develop new retinal prosthesis to address visual degeneration

A healthy retina contains photoreceptor cells that convert light changes into nerve impulses, which are then carried along the optic nerve to the brain, where they are decoded into images. Diseases such as retinitis pigmentosa cause the photoreceptor cells to stop functioning, while the rest of the eye remains healthy.

24 Jan 2018

in vitro News and Research

Researchers develop safe, potent mRNA vaccine adjuvants that can elicit effective immune response

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

Researchers describe human blood-nerve barrier transcriptome for the first time

First drug-candidate compounds discovered using AI licensed for development

Researchers reveal promising method for delivering cancer virotherapy

Researchers uncover novel therapeutic target for type 2 diabetes

Researchers receive major boost to explore long-standing paradigm in endocrinology

Researchers use innovative method to screen kinases for cancer drug's effectiveness

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Geneva researchers highlight new way to control tumor progression

Eating a Mediterranean diet may increase IVF success, finds study

Researchers develop new magnet-based method for delivering drugs directly to cancerous tissues

New organ-on-a-chip technology provides simple setting to study blood vessel formation

Study paves new way for development of vaccines against epidemics

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Eagle Biosciences launches novel Intact FGF23 ELISA Assay Kit

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

Biotechnology startup receives FDA clearance for synthetic bone graft substitute

Scientists imitate the Human Blood-retinal barrier on a microfluidic chip

BIST researchers develop new retinal prosthesis to address visual degeneration

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Why use light scattering to analyze proteins and viral vectors?

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