Medulloblastoma News and Research

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New way to carry drugs across the blood-brain barrier using nanoparticles

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Definition of low-risk WNT-pathway medulloblastoma may need to be refined, say experts

A new research perspective was published in Oncotarget's Volume 14 on February 7, 2023, entitled, "WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go?"

27 Feb 2023

New drug combination may offer better prognosis for children diagnosed with deadly brain cancer

Researchers at the University of Colorado Anschutz Medical Campus have discovered a drug combination that may offer a better prognosis for children diagnosed with MYC amplified Medulloblastoma, an often deadly form of brain cancer.

13 Jan 2023

Georgia State brain researcher receives NIH grant to create a model for personalized cancer treatments

A brain researcher at Georgia State University has been awarded a five-year, $3.06 million grant from the National Cancer Institute at the National Institutes of Health to create a model for personalized cancer treatments.

8 Dec 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Enzyme that drives growth of medulloblastoma may hold the key to future treatment

An enzyme that drives the growth of an often-lethal childhood brain cancer may hold the key to a future treatment, says a McMaster University-led study.

10 Nov 2022

Researchers identify gene expression correlated with response to chemotherapy in medulloblastomas

An international team led by the Department of Neurosurgery, Niigata University, has identified a new gene called Schlafen11 (SLFN11) whose expression is tightly correlated with response to chemotherapy in medulloblastomas, a highly malignant brain tumor affecting pediatric, adolescent, and young adult populations.

7 Nov 2022

New research lays the foundation for more effectively treating pediatric brain tumor

In a ground-breaking new study, scientists have uncovered the mechanics of the blood-tumor barrier, one of the most significant obstacles to improving treatment efficacy and preventing the return of cancerous cells.

1 Nov 2022

Specific stem cell protein found to be involved in the recurrence of medulloblastoma

The malignant brain tumor type medulloblastoma can become resistant to therapy which can cause relapse. Researchers at Uppsala University have discovered a certain protein that makes tumor cells resting and insensitive to radiation treatment.

28 Oct 2022

Medulloblastomas originate much earlier in pregnancy than previously thought and may be preventable

An aggressive type of pediatric brain tumor, medulloblastoma, exists in a pre-malignant form at birth after initially developing during the first or second trimester of pregnancy, according to a new international study.

21 Sep 2022

Scientists track origins of group 3 and group 4 medulloblastoma to the rhombic lip

Scientists at St. Jude Children's Research Hospital have discovered which cells give rise to certain high-risk groups of medulloblastoma.

21 Sep 2022

Hollings researcher awarded grant to continue research into mechanisms behind medulloblastoma relapse

When MUSC Hollings Cancer Center researcher Jezabel R. Blanco, Ph.D., began studying neurosciences, first as a graduate student and later as a postdoctoral fellow, her research was focused on understanding the mechanisms underlying brain disease, both in the context of neurodegeneration and cancer, but mostly from a basic research angle.

20 Jul 2022

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Effective and safe treatments are needed for medulloblastoma-;the most common type of cancerous brain tumor in children-;especially for patients whose cancer has spread to the spinal cord.

14 Jul 2022

Nemours Children’s Health scientists receive two NIH grants to advance pediatric cancer research

Nemours Children's Health researchers have received two grants from the National Institutes of Health (NIH) totaling $5 million.

12 Apr 2022

Aggressive brain tumor in children can be identified by analyzing cerebrospinal fluid

It may be possible to identify the presence of an aggressive brain tumor in children by studying their cerebrospinal fluid, according to new research led by Johns Hopkins Kimmel Cancer Center investigators.

2 Mar 2022

Drug combo delivered in a nanoparticle formulation extends the survival of mice with medulloblastoma

UNC Lineberger Comprehensive Cancer Center researchers have demonstrated that a novel combination of two drugs that act as targeted inhibitors, delivered in a nanoparticle formulation, extend the survival of mice with medulloblastoma.

27 Jan 2022

Study opens up prospects for using virotherapy to treat central nervous system tumors

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

11 Jan 2022