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Newly developed ChiTaRS database can collect cases of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play a vital role in the development of cancers and other complex diseases.

20 Nov 2019

Mechanisms preserving cell identity are based on status of proteins housing DNA

The inheritance, not only of DNA, but of changes to proteins that package it, maintains the identity of cells as they multiply, a new study finds.

31 Oct 2019

Scientists receive $1.6 million grant to study impact of phthalate exposure on male fertility

A cross-disciplinary team of scientists, led by University of Massachusetts Amherst environmental epigeneticist Richard Pilsner, will use a three-year, $1.6 million grant from the National Institute of Environmental Health Sciences to expand research into the impact of phthalate exposure on male fertility.

30 Oct 2019

Some types of proteins can stabilize damaged DNA

At the University of Copenhagen, researchers have discovered how some types of proteins stabilize damaged DNA and thereby preserve DNA function and integrity. This new finding also explains why people with inborn or acquired defects in certain proteins cannot keep their DNA stable and develop diseases such as cancer.

28 Oct 2019

Study finds molecular key to formation of mature and fully functioning T cells

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

25 Oct 2019

Researchers discover how the body repairs damaged DNA

Researchers from the University of Copenhagen have made an extraordinary discovery in how the body repairs damaged DNA, which can lead to better understanding and management of diseases such as cancer.

25 Oct 2019

Scientists successfully create age-resistant mice with hyper-long telomeres

Researchers have shown that it is possible to extend the life of mice by generating hyper-long telomeres, without using any gene modifying technologies.

17 Oct 2019

Advances in translational genetics unlocked by Bio-Rad technologies to be presented at ASHG 2019

Scientists will present 24 abstracts and three talks, highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR and single-cell ATAC-Seq (scATAC-Seq) technologies, at the 2019 American Society of Human Genetics Annual Meeting in Houston, October 15-19.

15 Oct 2019

How do gallstones form?

The human body is known to produce stones in various locations, most commonly in the kidneys, the bladder, the gallbladder and the appendix. Many of these stones appear without any obvious reason. However, a new study published in the journal Immunity shows the whole storyline for the first time: how gallstones are formed.

9 Oct 2019

Biology and computers meld to help understand how breast cancer develops

Among the most deadly killers in the area of cancer, breast cancer is also extremely difficult to treat, once it has spread to the bones. Not only does it metastasize rapidly, but it comprises a variety of cell types and also depends on the input from many other non-breast cells during the initiation, growth and spread of the cancer. This complexity makes it more difficult to develop targeted therapies in this condition.

8 Oct 2019

Researchers identify new targets to treat fibrotic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term - but bad when myofibroblast activation gets out of hand.

4 Oct 2019

Temporal fluctuations in protein concentrations can determine fate of stem cells

How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

26 Sep 2019

Discovery provides potential therapeutic target for prostate cancers with PTEN mutation

PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to function.

24 Sep 2019

Scientists move one step closer to discovering the causes of immune diseases

Scientists are one step closer to discovering the causes of immune diseases such as asthma, multiple sclerosis and arthritis

23 Sep 2019

Study shows how the immune system achieves antibody diversity

Diversity is good, especially when it comes to antibodies. It's long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies to conquer newly encountered threats.

15 Sep 2019

Research reveals new molecular mechanisms that contribute to plasticity of the adult brain

The team's findings describe for the first time the changes that take place in the genetic material of excitatory neurons in the hippocampus of adult mice when they activate.

12 Sep 2019

BIA Separations launches Cornerstone AAV Process Development Service to improve gene therapy production

BIA Separations, a leading bio-chromatography development and manufacturing company, today announced the introduction of CORNERSTONE AAV Process Development Service, a program of integrated process development services and novel technology designed to improve the robustness and yield of AAV-based gene therapy production, while improving the safety of therapeutic products.

12 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Study reveals surprising discoveries about poorly understood glioblastoma

Glioblastoma, a cancer that arises in the brain's supporting glial cells, is one of the worst diagnoses a child can receive. The grade IV, highly malignant tumor aggressively infiltrates healthy brain tissue, and most children die of the disease within one to two years of diagnosis, similar to adults.

12 Aug 2019

Researchers identify epigenetic mechanism that may strongly influence healthy aging

Researchers at the Max Delbrueck Center for Molecular Medicine have identified an epigenetic mechanism that appears to strongly influence healthy aging.

9 Aug 2019