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Resverlogix commences RVX-208 Phase 2 trial in pre-diabetes mellitus

Resverlogix Corp. today announced that it has initiated an exploratory Phase 2 clinical trial in patients with pre-diabetes mellitus to examine the effects of RVX-208 and ApoA-I production on glucose metabolism.

17 Oct 2012

PUFA levels reduced in schizophrenia patients

Patients with schizophrenia exhibit reduced red blood cell levels of certain polyunsaturated fatty acids, results from a systematic review and meta-analysis show.

16 Oct 2012

Experts blaze TRAIL for pulmonary arterial hypertension therapy

Researchers have shown that the cell signaling molecule tumor necrosis factor-related apoptosis-inducing ligand may be a potential therapeutic target for pulmonary arterial hypertension.

16 Oct 2012

Major academic medical centers, teaching hospitals to form Chicago Adult Congenital Heart Network

Seven major academic medical centers and teaching hospitals in the Chicago area have joined together to form the Chicago Adult Congenital Heart Network (CATCH), which is the first patient-centered, inter-institutional network in Chicago established to ensure all adults with congenital heart disease in the area receive appropriate follow-up care.

16 Oct 2012

Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

A comprehensive new review on how to treat high cholesterol and other blood lipid problems suggests that intensive treatment with high doses of statin drugs is usually the best approach.

16 Oct 2012

U-M professor receives 2012 ASA Excellence in Research Award

The American Society of Anesthesiologists (ASA) today presented Ralph Lydic, Ph.D. with its 2012 ASA Excellence in Research Award. Dr. Lydic, well known for his research on the neurobiology of sleep and breathing, received the award at the ANESTHESIOLOGY 2012 annual meeting in Washington, D.C.

16 Oct 2012

Gravity changes affect immune system development

New research findings recently published in The FASEB Journal, show that immune system development is affected by gravity changes, as reported by researchers from the University of Lorraine and University of Luxembourg. Astronauts are exposed to stresses, during launch and landing, which disrupts their body's natural defenses against infection. Changes to the immune system need to be investigated before astronauts undergo longer space missions.

16 Oct 2012

Flagellin in house dust may worsen allergic responses to inhaled substances

A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

16 Oct 2012

Maryland scientists create stem cell model for Gaucher disease

A new method of using adult stem cells as a model for the hereditary condition Gaucher disease could help accelerate the discovery of new, more effective therapies for this and other conditions such as Parkinson's, according to new research from the University of Maryland School of Medicine.

16 Oct 2012

Direct link between fuel exposure and damage to genetic material

An experiment carried out on rodents exposed to fuel similar to that of the Prestige tanker oil spill - which took place nearly a decade ago - shows that inhalation of the fuel causes damage to genetic material. According to the study, led by the University of A Coru-a, the results could be used in relation to people who carry out the industrial cleaning of coasts.

16 Oct 2012

Computerized checklist helps physicians to prevent dangerous venous thromboembolisms or PE

A computerized checklist system designed to help physicians identify and use the best methods of preventing potentially deadly blood clots in hospitalized trauma patients dramatically reduced the number of these dangerous venous thromboembolisms (VTEs), new Johns Hopkins research suggests.

16 Oct 2012

Hepatitis C rapid and point of care tests highly accurate and reliable

Timely screening and diagnosis is critical to the success of new treatments and ultimately to the survival of hepatitis C patients. A new study led by the Research Institute of the McGill University Health Centre (RI MUHC) is the first to show that hepatitis C rapid and point of care tests with a quick turnaround time are highly accurate and reliable as conventional first-line laboratory tests.

16 Oct 2012

Viewpoints: Cancer doctors reject 'phenomenally expensive' new drug; Protecting patients' rights

At Memorial Sloan-Kettering Cancer Center, we recently made a decision that should have been a no-brainer: we are not going to give a phenomenally expensive new cancer drug to our patients.

16 Oct 2012

NIAID-funded study to evaluate PPSV23 and PCV13 in Phase Iib pneumococcal trial

Researchers plan to see if a higher dose of a pneumococcal vaccine will create a stronger immune response in older adults who received an earlier generation vaccine against pneumonia and other pneumococcal diseases.

16 Oct 2012

Thymic stromal lymphopoietin molecule makes mice resistant to skin cancer

A molecule involved in asthma and allergies has now been shown to make mice resistant to skin cancer, according to scientists at Washington University School of Medicine in St. Louis.

16 Oct 2012

Roundup: Health care construction boom in Texas; Some Ga. schools, state authorities weigh leaving employee health plan

The Dallas-Fort Worth area is in the midst of an unprecedented health care building boom. You can see the most visible evidence in the Dallas medical district. There, several blocks apart, construction cranes signal more than $2 billion worth of new hospitals -; the $1.27 billion replacement for Parkland Memorial Hospital and an $800 million replacement hospital at UT Southwestern Medical Center.

16 Oct 2012

Researcher uncovers mechanisms involved in prognosis of acute myeloid leukemia

When patients suffering from Acute Myeloid Leukemia (AML) express high levels of the gene, MN1, an already aggressive leukemia is accelerated and shortens survival time. While that's a known fact, the mechanisms involved aren't well understood which is why a Wake Forest Baptist Medical Center researcher decided to take a closer look.

16 Oct 2012

Saint Louis University to participate in PPV23 vaccine trial for pneumonia

Saint Louis University is participating in a multi-site, National Institutes of Health-sponsored clinical trial in older adults of a new vaccine designed to protect against one of the most common types of pneumonia and related diseases such as bloodstream infections and meningitis.

16 Oct 2012

VeriStrat identifies NSCLC patients likely to respond to erlotinib

A study, published in the November 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, showed the plasma test VeriStrat can predict response but not survival benefit from erlotinib. The study was conducted on a subset of patients enrolled in the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non-small cell lung cancer patients.

16 Oct 2012

Soccer training can prevent cardiovascular disease in middle-aged men with hypertension

Playing soccer (football) could be the best way for people with high blood pressure, known as hypertension, to improve their fitness, normalise their blood pressure and reduce their risk of stroke.

16 Oct 2012