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Researchers suggest new therapeutic target for brain tumor

Johns Hopkins researchers say they have found a specific protein in nearly 100 percent of high-grade meningiomas — the most common form of brain tumor — suggesting a new target for therapies for a cancer that does not respond to current chemotherapy.

28 Aug 2013

Results from Phase II START study published in The Lancet Diabetes & Endocrinology

Results from the START clinical study (Study of Thymoglobulin to Arrest Newly Diagnosed Type 1 Diabetes), led by Dr. Steve Gitelman (University of California, San Francisco) and sponsored by the Immune Tolerance Network, are published today in The Lancet Diabetes & Endocrinology.

28 Aug 2013

URI professor studies rare hereditary disorder Fanconi anemia in children

When 2-year-old Logan Stevenson served as best man at his parents' wedding just days before he died of a rare genetic disorder, it drew international attention to a disease about which few people had ever heard. Hearing about Logan's story added another level of urgency to the research being conducted by University of Rhode Island Associate Professor Niall Howlett.

28 Aug 2013

Researchers develop ddPCR technology to quantify rejection biomarker in organ transplant injury

A recently reported blood test for the early detection of organ transplant injury could enable more timely therapeutic intervention in transplant patients and thus help to avoid longer term damage. As described by scientists at the University Medical Center G-ttingen and Chronix Biomedical, a molecular diagnostics company, the new method uses Bio-Rad Laboratories' Droplet Digital PCR (ddPCR-) technology to overcome the obstacles of earlier tests, which were both time-consuming and costly.

28 Aug 2013

Study shows ABL kinases have enhanced expression and activity in CML

Chronic Myelogenous Leukemia (CML) is a cancer of the white blood cells that is most commonly found in adults and in the elderly. Its incidence has been estimated to be 1 to 2 in 100,000 people. CML was the first cancer to be associated with a genetic abnormality, known as the Philadelphia Chromosome, which 95% of all CML patients carry in their cells.

28 Aug 2013

Study shows genetic test to classify gastric cancers and match them to therapies offer best outcomes

Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore.

28 Aug 2013

'Helper cells' improve survival rate of transplanted stem cells, finds study

Like volunteers handing out cups of energy drinks to marathon runners, specially engineered "helper cells" transplanted along with stem cells can dole out growth factors to increase the stem cells' endurance, at least briefly, Johns Hopkins researchers report.

28 Aug 2013

Study: Apoptosis triggers alternate replication pathway in HHV

Washington, DC-Researchers from Children's National Medical Center have found that an alternate, "escape" replication process triggered by apoptosis-the process of cell death or "cell suicide"-appears to be common in human herpesviruses (HHV).

28 Aug 2013

New compound offers way to treat migraine and other disorders of central nervous system

For many migraine sufferers, bright lights are a surefire way to exacerbate their headaches. And for some night-shift workers, just a stroll through a brightly lit parking lot during the morning commute home can be enough to throw off their body's daily rhythms and make daytime sleep nearly impossible. But a new molecule that selectively blocks specialized light-sensitive receptors in the eyes could help both these groups of people, without affecting normal vision.

28 Aug 2013

CST introduces HER3 antibody for studying HER2-mediated breast, lung and ovarian tumors

Cell Signaling Technology, Inc. of Danvers, MA, announced today that it has introduced a highly specific HER3 rabbit monoclonal antibody (mAb), an important addition for researchers studying HER2-mediated breast, lung and ovarian tumors.

From Cell Signaling Technology 28 Aug 2013

Haplogen, Cemm Offer Huge Collection Of Mutant Cell Lines

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27 Aug 2013

Novel Parkinson’S Target Uncovered

Researchers from Johns Hopkins and the National Cancer Institute (NCI) highlighted a novel mechanism underlying Parkinson's disease while simultaneously putting to rest a previously held theory regarding progression of the disorder. They also identified a compound that alleviates the disease's symptoms in mice.

27 Aug 2013

Haplogen, Cemm Offer Huge Collection Of Mutant Cell Lines

...

27 Aug 2013

Sigma Life Science releases genome editing tool for screening and exploratory studies

Sigma-Aldrich Corporation today announced that Sigma Life Science, its innovative biological products and services business, released Sigma CRISPRs, an inexpensive mammalian genome editing tool suitable for screening and exploratory studies.

27 Aug 2013

Vanderbilt adds genetic screening for drug tacrolimus to PREDICT program

Vanderbilt has added genetic screening for the drug tacrolimus to its personalize medicine pharmacogenomics program PREDICT. The new drug screening protocol was added following data that shows a single genetic variation largely impacts different dose requirements for patients.

27 Aug 2013

Research finding could lead to potential treatment for lymphedema

The molecule interleukin-7 is an important immune messenger protein which ensures that a sufficient number of T cells are present in our body for immune defence. Researchers from ETH Zurich have now demonstrated that IL-7 has another important function: it enhances the drainage function of lymphatic vessels, which collect fluid that has leaked out of blood vessels into the body tissue and return it to the bloodstream.

27 Aug 2013

Plymouth researcher receives award to develop lab-based mouse cell for research work

A researcher from Plymouth University Peninsula Schools of Medicine and Dentistry has received an award of - 94,365 (Sterling) from the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), for a pilot study to develop the lab-based creation of a type of mouse cell which could be used in place of the live animals for research related to infectious and allergic lung conditions.

27 Aug 2013

FDA grants Priority Review designation to sNDA for Nexavar tablets

Bayer HealthCare and Onyx Pharmaceuticals today announced that the U.S. Food and Drug Administration has granted Priority Review designation to the supplemental New Drug Application for the oral multi-kinase inhibitor Nexavar (sorafenib) tablets under evaluation for the treatment of locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer.

27 Aug 2013

Study reveals role of cadherin receptor BT-R3 in killing action of Cry4B mosquito toxin

Researchers at The University of Texas at Dallas (UTD), led by Dr. Lee Bulla, have demonstrated for the first time the selective cytotoxicity of Bacillus thuringiensis subsp. israelensis Cry4B toxin is mediated by BT-R3.

27 Aug 2013

Scientists finds link between protein phosphorylation and Parkinson's disease

Clues left at the scene of the crime don't always point to the guilty party, as EPFL researchers investigating Parkinson's disease have discovered. It is generally accepted that the disease is aggravated when a specific protein is transformed by an enzyme.

27 Aug 2013

Cell News and Research

Researchers suggest new therapeutic target for brain tumor

Results from Phase II START study published in The Lancet Diabetes & Endocrinology

URI professor studies rare hereditary disorder Fanconi anemia in children

Researchers develop ddPCR technology to quantify rejection biomarker in organ transplant injury

Study shows ABL kinases have enhanced expression and activity in CML

Study shows genetic test to classify gastric cancers and match them to therapies offer best outcomes

'Helper cells' improve survival rate of transplanted stem cells, finds study

Study: Apoptosis triggers alternate replication pathway in HHV

New compound offers way to treat migraine and other disorders of central nervous system

CST introduces HER3 antibody for studying HER2-mediated breast, lung and ovarian tumors

Haplogen, Cemm Offer Huge Collection Of Mutant Cell Lines

Novel Parkinson’S Target Uncovered

Haplogen, Cemm Offer Huge Collection Of Mutant Cell Lines

Sigma Life Science releases genome editing tool for screening and exploratory studies

Vanderbilt adds genetic screening for drug tacrolimus to PREDICT program

Research finding could lead to potential treatment for lymphedema

Plymouth researcher receives award to develop lab-based mouse cell for research work

FDA grants Priority Review designation to sNDA for Nexavar tablets

Study reveals role of cadherin receptor BT-R3 in killing action of Cry4B mosquito toxin

Scientists finds link between protein phosphorylation and Parkinson's disease

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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