Metabolic Disease News and Research

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Study of SLC13 transporters unlocks their therapeutic potential

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

19 Jun 2014

Healthy inflammation necessary to prevent metabolic diseases, study finds

Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research from UT-Southwestern Medical Center now finds that a level of "healthy" inflammation is necessary to prevent metabolic diseases, such as fatty liver.

19 Jun 2014

Medison to market uniQure's Glybera in Israel for treatment of lipoprotein lipase deficiency

uniQure N.V., a leader in human gene therapy, and Medison Pharma Ltd., Israel's leading international healthcare marketing group, today announced an exclusive distribution agreement under which Medison will market Glybera, uniQure's gene therapy product for the treatment of lipoprotein lipase deficiency (LPLD), in Israel and the Palestinian Authority.

18 Jun 2014

Wayne State researchers to study how exposures to stressors impact human health in Detroit

With over $2.4 million in new federal funding, Wayne State University researchers, regional collaborators at Henry Ford Health System, the University of Michigan and Michigan State University, and community partners will study how exposures to stressors that are prevalent in the urban industrialized environment — both chemical and non-chemical — impact human health in Detroit and beyond.

18 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

KineMed renews non-exclusive research collaboration with Pfizer

KineMed Inc. today announced the renewal of a non-exclusive research collaboration with Pfizer Inc. for the advancement of novel approaches in metabolic disease, in particular Type II diabetes.

4 Jun 2014

New data on Gilotrif and investigational compounds to be presented at 50th ASCO annual meeting

Boehringer Ingelheim today announced that new data will be presented from 7 abstracts for Gilotrif (afatinib) and investigational compounds, including nintedanib and BI 836845, from its oncology pipeline at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL, on May 30 – June 3, 2014.

31 May 2014

New discovery cracks code of metabolic pathway that allows certain cancerous tumors to thrive

In a breakthrough discovery at the Children's Medical Center Research Institute at UT Southwestern (CRI), a research team led by Ralph DeBerardinis, M.D., Ph.D., has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers.

23 May 2014

Rat pups exposed to tobacco smoke are at higher risk of developing metabolic disease

While many parents-to-be are aware that the health of their baby starts before they've actually arrived into the world, recent research reveals that "harm" (i.e., tobacco smoke, dirty air, poor nutrition, even preeclampsia) may not present itself disease-wise until well into adulthood or when a second harmful "hit" triggers the individual's susceptibility.

6 May 2014

Second Genome, Pfizer partner to conduct microbiome research to gain new insights into obesity

Second Genome announced today that it has entered into an agreement with Pfizer Inc. to conduct extensive microbiome research in a large observational study aimed at gaining new insights into obesity and metabolic disease.

2 May 2014

Gokhan S. Hotamisligil named recipient of the 9th Danone International Prize for Nutrition

Danone Institute International announced today that prominent scientist Gokhan S. Hotamisligil, MD, PhD, is the recipient of the 9th Danone International Prize for Nutrition for his outstanding research in immunology and metabolic diseases.

30 Apr 2014

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

Boehringer Ingelheim Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) and European Commission (EC) have granted Orphan Drug Designation to volasertib for acute myeloid leukemia (AML).

21 Apr 2014

Researchers explore link between diet, metabolic homeostasis and air pollutant exposure

Is air pollution connected with increases in obesity, diabetes, and chronic kidney disease? Researchers are providing insight into that question today at the Society of Toxicology 53rd Annual Meeting and ToxExpo in Phoenix, Ariz.

26 Mar 2014

New data shows curative effects of GFT505 in NASH associated with metabolic disorders

GENFIT, a biopharmaceutical company at the forefront of drug discovery and development, focusing on the early diagnosis and preventive treatment of cardiometabolic and associated disorders, today announces new data from Professor Isabelle Leclercq of Université Catholique de Louvain (Belgium) demonstrating the curative effects of GFT505 in an experimental model of NASH associated with metabolic disorders.

20 Mar 2014

Researchers discover potential new therapeutic target for controlling high blood sugar

A UT Southwestern Medical Center study has identified a new potential therapeutic target for controlling high blood sugar, a finding that could help the estimated 25 million Americans with type 2 diabetes.

19 Mar 2014

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by University of Maryland School of Public Health researchers.

13 Mar 2014

Patient with autistic behavior experiences improvements in mental health after liver transplant

A patient with a rare metabolic disease that causes liver failure and autistic behavior experienced significant improvements in both her physical and mental health after receiving a liver transplant, according to a new case report published in the American Journal of Transplantation.

12 Mar 2014

Study finds link between elevated urinary Gb3 and heart disease

A special newly discovered biomarker, "Gb3," potentially related to the survival of heart disease patients, could change the way the country's No. 1 killer is monitored in the future, according to research published in the Feb. 4 edition of the Journal of the American Heart Association.

11 Mar 2014

Researchers examine association between diabetes and obesity

It's by now well established that obesity is a major risk factor for diabetes. But what exactly is it about extra body fat that leads to insulin resistance and blood glucose elevation, the hallmarks of diabetes?

7 Mar 2014

Avaxia Biologics receives patent for oral anti-TNF antibodies for treatment of IBD

Avaxia Biologics, Inc., a clinical-stage biopharmaceutical company developing gut-targeted therapeutics, announced today that the company was awarded U.S. Patent No. 8,647,626, entitled "Compositions Comprising TNF-specific Antibodies for Oral Delivery."

12 Feb 2014

Metabolic Disease News and Research

Study of SLC13 transporters unlocks their therapeutic potential

Healthy inflammation necessary to prevent metabolic diseases, study finds

Medison to market uniQure's Glybera in Israel for treatment of lipoprotein lipase deficiency

Wayne State researchers to study how exposures to stressors impact human health in Detroit

Single dose restores normal cellular signaling in mouse model of autism

KineMed renews non-exclusive research collaboration with Pfizer

New data on Gilotrif and investigational compounds to be presented at 50th ASCO annual meeting

New discovery cracks code of metabolic pathway that allows certain cancerous tumors to thrive

Rat pups exposed to tobacco smoke are at higher risk of developing metabolic disease

Second Genome, Pfizer partner to conduct microbiome research to gain new insights into obesity

Gokhan S. Hotamisligil named recipient of the 9th Danone International Prize for Nutrition

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

Researchers explore link between diet, metabolic homeostasis and air pollutant exposure

New data shows curative effects of GFT505 in NASH associated with metabolic disorders

Researchers discover potential new therapeutic target for controlling high blood sugar

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

Patient with autistic behavior experiences improvements in mental health after liver transplant

Study finds link between elevated urinary Gb3 and heart disease

Researchers examine association between diabetes and obesity

Avaxia Biologics receives patent for oral anti-TNF antibodies for treatment of IBD

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