Hypoxia News and Research

RSS

Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

Researchers discover how muscles regulate oxygen consumption

A new study by researchers from Karolinska Institutet shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.

3 Apr 2018

International researchers discover link between congenital heart defects and adrenal gland cancer

An international team led by Dr. Patricia Dahia, M.D., Ph.D., of UT Health San Antonio, discovered a genetic mutation that explains why adults with severe congenital heart defects--who live with low oxygen in their blood--are at dramatically high risk for adrenal gland cancer.

29 Mar 2018

Research provides better understanding of how cancerous cells behave in low oxygen

An international team of researchers found how cancer cells respond to DNA damage signaling when in low oxygen, or hypoxia.

21 Mar 2018

Multi-center study to evaluate promising new intervention for upper limb dysfunction after SCI

Kessler Foundation has been awarded an $857,600 sub-award from the Department of Health and Human Services, Administration for Community Living, National Institute on Disability, Independent Living, and Rehabilitation Research, to study a promising new intervention for upper limb dysfunction after spinal cord injury (SCI).

16 Mar 2018

Latest Atmospheric Control Unit now available for BMG LABTECH’s budget-friendly product line

Cell-based assays have become an important application in the life science sector, from basic to top-level research. They are widely used in biotech companies and academic research institutions to monitor cell health in real-time.

From BMG LABTECH GmbH 16 Mar 2018

Korean scientists track growth, migration of cells under hypoxic conditions using xCELLigence RTCA

Tracking the growth and migration of cells under hypoxic conditions in vitro can be challenging because measurements must be made in a manner that does not perturb the atmospheric composition of the closed system.

13 Mar 2018

Researchers discover how the body skillfully extinguishes inflammation

Inflammation needs energy An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly.

23 Feb 2018

Researchers devise strategies to target glioma stem cells that could improve patient survival

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

5 Feb 2018

Inadequate oxygen levels during sleep increase risk of developing Alzheimer's disease

Inadequate oxygen levels during sleep can damage the brain and increase the risk of developing Alzheimer's disease, University of Queensland researchers have found.

31 Jan 2018

Enzyme inhibitor and chemotherapy combination regresses glioblastoma

In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

24 Jan 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

Research opens door to development of new treatment for type 2 diabetes

The team lead by Sílvia Vilares Conde, from CEDOC-NOVA Medical School, in collaboration with the pharmaceutical company Galvani Bioelectronics, demonstrated through findings in rats that is possible to restore insulin sensitivity and glucose homeostasis, by modulating electrically the carotid sinus nerve, the sensitive nerve that connects the carotid body with the brain. The study is published in Diabetologia, the journal of the European Association for the Study of Diabetes.

15 Jan 2018

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

When a coronary artery is obstructed by atheroma, blood flow is depressed or even arrested. This causes hypoxia of cardiac cells associated with the deprivation of nutrients. In clinic, the first objective is to restore blood flow. However, this is associated with a burst in oxidation of cellular proteins and lipids. This oxidation enhances cell death and participates to the so-called reperfusion injury.

From Logos Biosystems 18 Dec 2017

Researchers develop molecular beacon to find hypoxic spots in real time

Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. University of Illinois researchers have developed a way to find hypoxic spots noninvasively in real time.

8 Dec 2017

Groundbreaking study identifies protein as potential factor in cancer metastasis

U of G scientists have made a discovery that could reduce the spread of cancer by hindering a protein that binds cancer cells together and allows them to invade tissues.

17 Nov 2017

Study identifies promising treatment to reduce brain injury in babies

Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen.

10 Nov 2017

Scientists explore role of nitric oxide in brain tissue in simulated ischemia

A joint study conducted by scientists at the National Academy of Sciences in Belarus and Kazan Federal University in Russia, looks at the role of nitric oxide (NO) in brain tissue in simulated ischemia in rats.

10 Nov 2017

Researchers find new way to restrict ability of cancer to use glucose for energy

Cancer cells consume exorbitant amounts of glucose, a key source of energy, and shutting down this glucose consumption has long been considered a logical therapeutic strategy.

7 Nov 2017

Cleveland Clinic researcher awarded $2.6 million grant to create innovative models of colorectal cancer

Cleveland Clinic researcher Emina Huang, M.D., a colorectal surgeon in the Digestive Disease and Surgery Institute and a staff member in the Lerner Research Institute's Department of Stem Cell Biology and Regenerative Medicine, has been awarded a collaborative five-year, $2.6 million grant from the National Cancer Institute to create innovative models of colorectal cancer that will enhance understanding of how the disease develops and spreads.

31 Oct 2017

Developmental abnormality discovered in babies linked to SIDS

International research involving the University of Adelaide has uncovered a developmental abnormality in babies - especially in premature babies and in boys - that for the first time has been directly linked to cases of sudden infant death syndrome (SIDS).

25 Oct 2017