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New state of myosin in cardiac muscle with low ATP turnover rate could decrease metabolic load of myocardium

New insight into the physiology of cardiac muscle may lead to the development of therapeutic strategies that exploit an inherent protective state of the heart. The research, published by Cell Press online on April 19th in the Biophysical Journal, discovers a state of cardiac muscle that exhibits a low metabolic rate and may help to regulate energy use and promote efficiency in this hard-working and vital organ.

20 Apr 2011

Cord blood units treated with signaling molecule show favorable safety profile in long-term animal studies

An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report scientists from Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Children's Hospital Boston.

20 Apr 2011

First hand transplant in western United States

Ms Emily Fennell, a 26-year-old California woman became the first person in the western United States to receive a hand transplant.

19 Apr 2011

Single antibody injection limits tissue and organ destruction after ischaemic events

Medical researchers today held out promise that a simple injection is being developed to limit the devastating consequences of heart attacks and strokes.

19 Apr 2011

Journal of Clinical Oncology publishes CytRx tamibarotene Phase 2b trial results in APL

CytRx Corporation, a biopharmaceutical company specializing in oncology, today announced the publication of a case report in the peer-reviewed Journal of Clinical Oncology documenting the use of tamibarotene in the successful treatment of a patient with recurrent advanced-stage acute promyelocytic leukemia.

19 Apr 2011

New guidelines for cardiac specialists

A series of new guidelines for cardiac specialists has been developed to determine when heart failure patients should receive a mechanical heart-pumping device.

18 Apr 2011

New results from largest multicenter clinical trial for heart transplant patients be released at ISHLT 2011

New results from the largest multicenter clinical trial for heart transplant patients will be released this week at the International Society for Heart & Lung Transplantation 31st Annual Meeting and Scientific Sessions in San Diego. Results show clinical benefit for the use of Everolimus in heart transplant patients.

16 Apr 2011

Roundup: Medicaid bill headed for Florida Senate floor; Texas nursing home funding vulnerable in state budget

The Texas Legislature is faced with a budget challenge that has pitted the Republican majority's desire to cut government spending against a vulnerable target: nursing homes.

16 Apr 2011

Top-line results from Pfizer's tofacitinib Phase 3 study in rheumatoid arthritis

Pfizer Inc. announced today top-line results from the ORAL Scan Phase 3 study of tofacitinib, formerly known as tasocitinib, an investigational, novel, oral JAK inhibitor.

15 Apr 2011

Patients with heart failure can benefit from left ventricular assist device

Non-cardiac surgery can be performed safely in patients with a heart device typically implanted into patients waiting for a transplant, according to a study at Henry Ford Hospital in Detroit.

15 Apr 2011

Cytonet initiates clinical trial using liver cell infusion to treat urea cycle disorders in children

International biotechnology firm Cytonet recently launched the first ever clinical trial in the United States using an investigational liver cell infusion to treat urea cycle disorders (UCD) in children. The first patient in the Phase II trial, which will seek to enroll 20 patients in 12 medical centers, is a child with citrullinemia, which is a hereditary UCD. He received six liver cell infusions on six consecutive days at Yale School of Medicine in New Haven, Conn.

15 Apr 2011

Genzyme reports positive data from 5-year alemtuzumab Phase 2 study in MS

Genzyme Corp., a subsidiary of sanofi-aventis Group, today reported additional five-year patient data from its completed Phase 2 multiple sclerosis (MS) trial showing that nearly two-thirds of alemtuzumab treated patients remained free of clinically-active disease as much as four years after most patients received their last course of the investigational drug.

15 Apr 2011

Donor-specific antibodies may accelerate arteriosclerosis after kidney transplantation

Kidney transplant recipients who develop antibodies in response to receiving new organs can develop accelerated arteriosclerosis, or narrowing of the arteries that supply blood to the kidney, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results indicate that arteriosclerosis resulting from such donor-specific antibodies may play an important role in organ rejection following transplantation.

15 Apr 2011

Sea squirt study may help solve organ rejection problems in humans

Studies of the small sea squirt may ultimately help solve the problem of rejection of organ and bone marrow transplants in humans, according to scientists at UC Santa Barbara.

15 Apr 2011

Experts suggest Fukushima clean-up workers store blood cells for future use

As Japan still reels with the after effects of the March 11 earthquake and tsunami, and radiation exposure, plant workers are working to control the radiation leakage from the Fukushima Daiichi complex. Experts note that the work there will take years, posing a risk of accidental exposure.

15 Apr 2011

Pig stem cell transplants key to future research into retina treatment

A team of American and Chinese scientists studying the role of stem cells in repairing damaged retina tissue have found that pigs represent an effective proxy species to research treatments for humans. The study, published in STEM CELLS, demonstrates how cells can be isolated and transplanted between pigs, overcoming a key barrier to the research.

13 Apr 2011

Sirolimus may help treat lymphangioleiomyomatosis in women

An Oregon Health & Science University researcher has co-authored an international study that revealed a drug approved to prevent rejection in organ transplant patients helped treat a rare lung disease in women.

12 Apr 2011

Periodontal ligament stem cells most efficacious among dental tissue-derived stem cells

Periodontal ligament stem cells (PDLSCs) have been found to be the most efficacious of three kinds of clinically tested dental tissue-derived stem cells, reports a study published in the current issue of Cell Transplantation (20:2), freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

12 Apr 2011

Early uMSC transplantation may treat lupus nephritis

Human umbilical cord blood-derived mensenchymal stem cells have been found to offer benefits for treating lupus nephritis when transplanted into mouse models of systemic lupus erythematosus.

12 Apr 2011

UMMC Professor receives American College of Physicians' highest honor

Dr. Joe Files, professor of medicine and director of the Division of Hematology at the University of Mississippi Medical Center, has received his mastership from the American College of Physicians, joining a select group of Mississippi physicians who have received the national organization’s highest recognition.

11 Apr 2011

Transplant News and Research

New state of myosin in cardiac muscle with low ATP turnover rate could decrease metabolic load of myocardium

Cord blood units treated with signaling molecule show favorable safety profile in long-term animal studies

First hand transplant in western United States

Single antibody injection limits tissue and organ destruction after ischaemic events

Journal of Clinical Oncology publishes CytRx tamibarotene Phase 2b trial results in APL

New guidelines for cardiac specialists

New results from largest multicenter clinical trial for heart transplant patients be released at ISHLT 2011

Roundup: Medicaid bill headed for Florida Senate floor; Texas nursing home funding vulnerable in state budget

Top-line results from Pfizer's tofacitinib Phase 3 study in rheumatoid arthritis

Patients with heart failure can benefit from left ventricular assist device

Cytonet initiates clinical trial using liver cell infusion to treat urea cycle disorders in children

Genzyme reports positive data from 5-year alemtuzumab Phase 2 study in MS

Donor-specific antibodies may accelerate arteriosclerosis after kidney transplantation

Sea squirt study may help solve organ rejection problems in humans

Experts suggest Fukushima clean-up workers store blood cells for future use

Pig stem cell transplants key to future research into retina treatment

Sirolimus may help treat lymphangioleiomyomatosis in women

Periodontal ligament stem cells most efficacious among dental tissue-derived stem cells

Early uMSC transplantation may treat lupus nephritis

UMMC Professor receives American College of Physicians' highest honor

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