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Functional genomics provide improved drug discovery

Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins.

20 Apr 2004

Myriad Genetics advances drug for chemotherapy-induced nausea

Myriad Genetics, Inc. today released new data on MPC-4505, its Neurokinin-1 (NK1) receptor antagonist, a drug candidate for chemotherapy-induced nausea and vomiting (emesis). MPC-4505 is a potent, orally bioavailable, CNS-penetrating, highly selective NK1 antagonist.

20 Apr 2004

Likely closure of Queen Mother's Maternity Hospital

Members of Greater Glasgow NHS board will consider the financial crisis at today's meeting. The same meeting is expected to take a decision on closing the Queen Mother's Maternity Hospital – a proposal which has already caused uproar in the west of Scotland and beyond.

20 Apr 2004

Microscission blasts drugs through skin

Nightmares of doctors or dentists with oversized hypodermic needles could soon be a thing of the past. A new painless way of delivering drugs through the skin is described in the journal BMC Medicine this week – and needles are not involved.

19 Apr 2004

New ways to fight type 2 diabetes

Adults with type 2 diabetes who have just one additional risk factor for heart disease should be taking medication to lower cholesterol levels, according to new guidelines from the American College of Physicians (ACP).

19 Apr 2004

Jefferson scientists learn how HIV causes dementia

Ever since the AIDS epidemic began more than two decades ago, scientists have been trying to understand why as many as one-quarter of those infected with HIV develop dementia.

19 Apr 2004

Two recent innovations look set to revolutionize biomedical treatment.

The first innovation is probably the world’s first multiple drug-eluting biodegradable stent for use in any part of the body where fluid flow, including blood, is disrupted.

19 Apr 2004

FDA announces science-based approach to protecting Americans from unsafe dietary supplements

Speaking before the American Society for Pharmacology and Experimental Therapeutics (ASPET) and the American Society for Nutritional Sciences, Dr. Lester M. Crawford, Acting Commissioner of the Food and Drug Administration (FDA), today outlined the agency's science-based approach to protecting American consumers from unsafe dietary supplements.

19 Apr 2004

Proteomics helps fight colon cancer

Using new technology associated with the study of proteins, or proteomics, scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and their colleagues have made a step toward predicting which people with familial adenomatous polyposis.

19 Apr 2004

New evidence that brain circuits involved in drug addiction are also activated by the desire for food

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have produced new evidence that brain circuits involved in drug addiction are also activated by the desire for food.

19 Apr 2004

Estrogen–like drugs may help postmenopausal women

Scientists may debate whether weight gain is a side effect of menopause, but the numbers are clear: On average, women may experience a gain of approximately 10-15 pounds in the years surrounding menopause.

19 Apr 2004

Menthol in topical creams relieves Osteoarthritis pain

A new study extends previous research and examines the effects of a topical cream consisting of cetylated fatty acids, along with the addition of menthol, on pain and functional performance in patients with knee osteoarthritis over the course of one week.

19 Apr 2004

New scanning technology allows researchers to look into a kidney

Kidney disease may affect as many as one in twelve people, and causes millions of deaths each year. Currently, the diagnosis of kidney function relies mainly on blood and urine tests, an indirect means of figuring out how well they’re working.

19 Apr 2004

Australian company set to spearhead drug discovery

An Australian company is set to challenge the boundaries of drug discovery in Australia with the unveiling of the nation's top drug discovery facility by Western Australian Minister for State Development, Clive Brown.

19 Apr 2004

Researchers find drug that may suppress genetic mutation using a novel screening approach

Researchers at Massachusetts General Hospital have developed a way of identifying promising new drugs that may get around a major challenge in drug discovery.

18 Apr 2004

Newborn lambs’ central heating system could aid fat busting in humans

The way newborn lambs regulate their temperature in the first few weeks of life using a special deposit of brown fat could give clues for tackling obesity in humans, according to Imperial College London scientists.

18 Apr 2004

Abbott Laboratories attempt to silence AIDS advocates

In a brazen attempt to silence AIDS advocates' ongoing criticism of Abbott Laboratories over its recent 400% price hike on the key AIDS drug Norvir, two prominent gay publications are buckling under pressure from Abbott to refuse to run, or significantly alter, a parody advertisement created by AIDS Healthcare Foundation (AHF) that spoofs the drug giant's media spin on their unprecedented price hike on Norvir.

16 Apr 2004

Delirium in ICU patients a predictor of mortality

Between 60 percent to 80 percent of these patients develop a brain dysfunction known as delirium, which according to a group of physicians at Vanderbilt Medical Center is an independent predictor of mortality.

16 Apr 2004

Scientists will debate E.coli and the adaption by micro-organisms to modern day drugs

This debate will centre around why humans are constantly under attack from infectious diseases such as E.coli despite medical advances in vaccinations and antibiotics, and how micro-organisms that cause disease evolve and adapt quickly to the many barriers that our bodies' anti-infection strategies and our drugs industry throw at them.

16 Apr 2004

New gene presents a potent new target for breast cancer therapy

A gene known to promote longevity in animals has now been discovered to encode a tumor suppressor – a protein that helps prevent cancer, according to a study by a team of scientists from The University of Texas M. D. Anderson Cancer Center. The new gene, which was inactivated in two-thirds of patients studied, presents a potent new target for breast cancer therapy, the researchers say.

16 Apr 2004