Hypothalamus News and Research

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The Hypothalamus is the area of the brain that controls body temperature, hunger, and thirst.

Rett syndrome gene found to be full of surprises

A study funded by the National Institutes of Health (NIH) has transformed scientists' understanding of Rett syndrome, a genetic disorder that causes autistic behavior and other disabling symptoms. Until now, scientists thought that the gene behind Rett syndrome was an "off" switch, or repressor, for other genes. But the new study, published today in Science, shows that it is an "on" switch for a startlingly large number of genes.

29 May 2008

New dimension discovered in body clock rhythm

Research on what makes the body clock tick has led Dr Michael Hastings of the MRC Laboratory of Molecular Biology in Cambridge to discover a new and unanticipated cog in the human body clock. A patent for the compound involved has been filed by MRC Technology. The results, published in Science, could lead to therapies for people whose sleep is disrupted by shift work or old age.

18 May 2008

Blocked brain enzyme shows potential as target for appetite control, weight loss and blood sugar management

Imagine being able to tone down appetite and promote weight loss, while improving the body's ability to handle blood sugar levels.

6 May 2008

Gut hormone makes food appear more desirable

A gut hormone that causes people to eat more does so by making food appear more desirable, suggests a new report in the May issue of Cell Metabolism, a publication of Cell Press. In a brain imaging study of individuals, the researchers found that reward centers respond more strongly to pictures of food in subjects who had received an infusion of the hormone known as ghrelin.

6 May 2008

NYU dental professor discovers biological clock linking tooth growth to other metabolic processes

This clock, or biological rhythm, controls many metabolic functions and is based on the circadian rhythm, which is a roughly 24-hour cycle that is important in determining sleeping and feeding patterns, cell regeneration, and other biological processes in mammals.

7 Apr 2008

Bardet-Biedl syndrome provides clues on obesity, blood pressure

University of Iowa researchers have found a clue about how resistance to the hormone leptin might disrupt the brain signals that tell the body when to stop eating.

4 Mar 2008

Brain differences between women and men

What was once speculation is now being confirmed by scientists: the brains of women and men are different in more ways than one.

1 Mar 2008

Adult-onset obesity seen in mice when gene ubiquitin disrupted

Texas and California scientists who disrupted one type of the gene ubiquitin (Ubb) in mice observed neuronal death in the hypothalamus, impaired control of energy balance and adult-onset obesity in the rodents.

27 Feb 2008

Insulin administered intranasally may lower food intake in men, improve memory in women

Insulin administered intranasally, acutely decreases food intake in men but not women and in contrast, the compound improves memory function in women but not men according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).

22 Feb 2008

Stress hormone impacts memory, learning in diabetic rodents

Diabetes is known to impair the cognitive health of people, but now scientists have identified one potential mechanism underlying these learning and memory problems.

18 Feb 2008

Predisposition for obesity might be wired into the brain

A predisposition for obesity might be wired into the brain from the start, suggests a new study of rats in the February issue of Cell Metabolism, a publication of Cell Press.

7 Feb 2008

Deep brain stimulation may improve memory

Deep brain stimulation (DBS) surgery, which is used to treat Parkinson's disease and other movement disorders, is now being studied for its potential to treat a variety of conditions.

4 Feb 2008

Overeating and obesity triggered by lack of brain-derived neurotrophic factor

According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight.

28 Dec 2007

Blind humans lacking rods and cones retain normal responses to non-visual effects of light

In addition to allowing us to see, the mammalian eye also detects light for a number of "non-visual" phenomena.

14 Dec 2007

Brain may have important influences on glucose metabolism and insulin action

An appetite-suppressing chemical also improves glucose tolerance and lowers insulin levels in obese and diabetic mice, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

13 Nov 2007

Brain appears to play important role in glucose metabolism and insulin action

6 Nov 2007

Study identifies pathway required for normal reproductive development

Massachusetts General Hospital (MGH) clinical researchers, in collaboration with basic scientists from the University of California, Irvine (UC Irvine) have identified a new molecular pathway required for normal development of the reproductive, olfactory and circadian systems in both humans and mice.

17 Oct 2007

Insomniac fish help understand the genetics behind sleep disorders

Scientists at the Stanford University School of Medicine have hooked a fish that suffers from insomnia in their quest to understand the genetics behind sleep disorders.

16 Oct 2007

Scientists identify brain circuits that 'decide' how much we eat

Scientists have identified the brain circuits that 'decide' how much we eat. Using live brain scanning techniques and an innovative study design, researchers have discovered how the brain controls food intake in humans. Their findings are published in Nature.

15 Oct 2007

Low birth weight children may be at a greater risk of stress-related health problems as adults

Findings from this study show that low birth weight (below the 10th percentile) can lead later in life to low concentrations of cortisol, a hormone that regulates stress response by adjusting blood pressure and blood sugar levels.

27 Sep 2007