Pathophysiology News and Research

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Scientists highlight advances and uses of organoids in gastroenterology and hepatology

One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo.

4 Jun 2019

Five new genetic risk loci associated with maximum habitual alcohol use identified

A genome-wide association study has identified five new genetic risk loci that can pass on risk for harmful alcohol use from parents to children, and confirmed one previously identified risk locus.

28 May 2019

KAIST research team finds cause of sepsis-induced lung injury

A KAIST research team succeeded in visualizing pulmonary microcirculation and circulating cells in vivo with a custom-built 3D intravital lung microscopic imaging system.

7 May 2019

Cannabis, Alcohol and the Epigenome

With the legalization of cannabis in many US states, we explore the epigenetic effects of cannabis, cannabis-derived products, and alcohol.

29 Apr 2019

New research on psychological and neural basis of Post-Traumatic Stress Disorder

Dr. Stephen Maren, University Distinguished Professor in the Department of Psychological & Brain Sciences, recently published significant research on the psychological and neural basis of Post-Traumatic Stress Disorder.

12 Apr 2019

The two-hit model can lead to better understanding of heart failure

Nearly half of current hospital admissions for heart failure are caused by a type of the disease with no treatment options. Cardiology researchers at UT Southwestern Medical Center are changing that reality with a fresh approach, recently published in Nature.

12 Apr 2019

Bronchiectasis patients often display high sensitivity to airborne allergens

An international research team led by Nanyang Technological University, Singapore (NTU Singapore) has found that patients with the lung disease bronchiectasis also often display sensitivity to airborne allergens, and has highlighted the particular role that fungi appear to play.

4 Apr 2019

Study: Pathogenetic downregulation of adenosine linked to restless leg syndrome

Researchers have identified a common mechanism implicating adenosine in the cause of restless leg syndrome symptoms — the periodic limb movements characteristic of RLS and the state of enhanced arousal that both disrupt sleep.

4 Apr 2019

Study identifies gene variant associated with accelerated cellular aging

It is well known that psychiatric stress is associated with accelerated aging. Now, a new study shows that a gene mutation interacts with multiple types of psychiatric stress including post-traumatic stress disorder (PTSD), pain and sleep disturbances in association with cellular aging.

20 Mar 2019

Holotomography (HT) technology used to image individual neurons

A Korean research team has demonstrated quantitative morphological profiling of individual neurons using Holotomography (HT) technology developed by Tomocube.

From Tomocube Inc. 14 Mar 2019

Better regulation of the immune system may help manage preeclampsia

Boosting the body's levels of interleukin-4 (IL-4)--an immune system protein that controls inflammation--may help manage the pregnancy complication preeclampsia, according to a new rodent study.

7 Mar 2019

$Evaluation and management of heart failure with preserved ejection fraction in women$

Evaluation and management of heart failure with preserved ejection fraction in women

In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P. Velarde) pp. 409-420(12); DOI: https://doi.org/10.15212/CVIA.2017.0062 Juan R. Vilaro, MD, Mustafa Ahmed, MD and Juan M. Aranda Jr. MD from the Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA consider heart failure with preserved ejection fraction.

2 Mar 2019

Risk factors and noninvasive diagnostic assessment of NOCAD in women

In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P. Velarde) pp. 349-361(13); DOI: https://doi.org/10.15212/CVIA.2017.0077 Keith C. Ferdinand, MD and Rohan Samson, MD from the Tulane University Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA consider nonobstructive coronary artery disease in women: risk factors and noninvasive diagnostic assessment.

1 Mar 2019

Noninvasive imaging tools to detect stable ischemic heart disease in women

In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P. Velarde) pp. 375-389(15); DOI: https://doi.org/10.15212/CVIA.2019.0007 Viviany R. Taqueti from the Cardiovascular Imaging Program, Heart and Vascular Center, Division of Cardiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA reviews novel imaging approaches for the diagnosis of stable ischemic heart disease in women.

1 Mar 2019

Association between OSA and cardiovascular diseases in women

In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P. Velarde) pp. 421-434(14); DOI https://doi.org/10.15212/CVIA.2017.0064, Nimeh Najjar, MD, Peter Staiano, MD and Mariam Louis, MD from the University of Florida, Department of Medicine, Jacksonville, FL, USA consider obstructive sleep apnea and cardiovascular disease in women.

28 Feb 2019

New study outlines sex-specific issues in ischemic heart disease

Cardiovascular disease is a leading cause of morbidity and death among women. Our knowledge of ischemic heart disease has grown tremendously over the past few decades as sex differences in prevalence, presentation, and pathophysiology are increasingly being recognized.

17 Feb 2019

New mouse model replicates development and progression of Type I diabetes

Researchers at The University of Toledo have found a new way to replicate in lab mice the development and progression of Type I diabetes, a breakthrough that has the potential to reshape how the chronic disease is studied.

13 Feb 2019

A new treatment for Chlamydia via Canadian researchers

A new way to prevent and treat one of the commonest sexually transmitted infections (STIs) has been developed by the researchers at the University of Manitoba and the University of Waterloo. This new method is more of a gene therapy than antibiotic therapy against the infection.

6 Feb 2019

Special Feature: World Cancer Day

This World Cancer Day, we provide information and advice for those who want to reduce their risk of cancer, are caring for someone with cancer or simply want to learn more.

4 Feb 2019

Chemicals used to flavor e-cigs may impair lung function

Two chemicals widely used to flavor electronic cigarettes may be impairing the function of cilia in the human airway, according to a new study led by Harvard T.H. Chan School of Public Health.

1 Feb 2019