Liver Transplant News and Research

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When a patient presents with end stage liver disease or liver failure he or she may be considered for a liver transplantation. The first step in this is often a rigorous assessment and being placed on a waiting list.

Outcome of patients with hepatitis B and HIV infections referred for liver transplantation

A new study on HIV patients who also had Hepatitis B virus (HBV) found that better outcomes are possible if they are referred early for transplant and treated with a combination of drugs for HBV. It is essential to monitor the HBV status of these patients, however, in order to control the emergence of drug-resistant HBV infection.

3 May 2006

Trends over a decade of pediatric liver transplantation in the U.S.

A new study on children undergoing liver transplants found that although innovative transplant techniques have been developed in recent years, the waitlist times for pediatric transplant candidates have increased compared to the early 1990s.

6 Apr 2006

ICG value accurately predicts outcomes in adult living-donor liver transplantation

A new study on identifying which patients were likely to have poor outcomes following a living-donor liver transplant (LDLT) found that measuring how a certain non-toxic dye was eliminated by the liver shortly after surgery was an accurate indicator of liver function, and therefore a reliable indicator of the outcome of the procedure.

4 Apr 2006

Exposure to toxins from hazardous waste sites may be a significant risk factor for developing primary biliary cirrhosis

Published in the March 2006 issue of Hepatology, researchers found significant clusters of the disease near Superfund toxic waste sites (SFS) and that the majority of patients in New York City who need liver transplants because of PBC, reside near SFS.

13 Mar 2006

Validation of cardiovascular risk scores in a liver transplant population

Two methods of assessing a patient's risk of cardiovascular events - SCORE and PROCAM - proved more valuable for liver transplant recipients than an alternative method, according to a new study.

7 Mar 2006

Liver transplantation from non-heart beating donors

Liver transplants from non-heart beating donors have the potential to increase the supply of organs by as much as 20%, according to experts in this week's British Medical Journal.

17 Feb 2006

Hepatitis C recurs rapidly after liver transplant

When a diseased liver is removed from a patient with Hepatitis C (HCV), serum viral levels plummet. However, after receiving a healthy liver transplant, virus levels rebound and can surpass pre-transplant levels within a few days, according to a new study published in the February 2006 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

2 Feb 2006

French defend drug after patients develop liver problems

Health authorities in the U.S. are recommending that doctors keep a close eye on patients taking Ketek for signs of liver problems and to stop treatment if symptoms develop.

24 Jan 2006

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy. Cyclosporine also showed efficacy against Hepatitis C virus in vitro.

5 Jan 2006

Liver transplants may not be suitable for all cystic fibrosis patients

A new study on patients with cystic fibrosis (CF) who have had abnormal bleeding from ruptured blood vessels in the esophagus (variceal hemorrhage) as a result of liver disease found that transplant may not be indicated if there are no other indications of advanced liver disease.

5 Dec 2005

Hospital liver transplant program suspended after 32 die waiting

Following reports in the media that a Southern California hospital had suspended its liver transplant program and had turned down scores of donor organs while 32 patients awaiting transplants had died, the facility has had it's certification of the liver transplant program revoked.

14 Nov 2005

Public health service to fund live liver transplants

An announcement that new organ transplant technology will now allow adult patients to receive liver transplants from a living relative for the first time on the NHS, marks a new era in public health services.

8 Nov 2005

HIV-positive patients have shorter survival periods while awaiting liver transplants

A new study on HIV-positive patients eligible for liver transplants found that their survival while waiting for a transplant is significantly shorter than patients who are HIV-negative.

7 Nov 2005

Liver services in the United Kingdom need better funding and better staffing

Mortality from liver disease is increasing in the UK. In 2000 liver disease killed more men than Parkinson's disease and more women than cancer of the cervix. Deaths from alcoholic liver disease has doubled in the past 10 years, while liver disease arising from hepatitis C infection is expected to treble by 2020.

13 Oct 2005

20 percent of people with chronic hepatitis C who receive a liver transplant will develop advanced cirrhosis

A new study from the University of North Carolina at Chapel Hill School of Medicine may have found a way to identify those at greatest risk, thereby allowing doctors to decide who should receive treatment that could save the transplanted organ. The new findings appear in the October issue of the journal Liver Transplantation.

9 Oct 2005

Discovery of mechanisms causing portal hypertension

A physician-scientist at UT Southwestern Medical Center and his research team have identified mechanisms causing a potentially deadly type of hypertension that results from liver damage – findings that could lead to its prevention.

3 Oct 2005

Potential biomarker that could be used to predict who might develop hepatic fibrosis

Two new studies on Hepatitis C (HCV) patients who underwent liver transplants examined a potential biomarker that could be used to predict who might develop hepatic fibrosis, a formation of scar-like tissue that can lead to cirrhosis.

3 Oct 2005

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network has launched its second clinical trial to study NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol. The first trial, launched in January of this year, focuses on adults, while the second trial studies the disease in children.

27 Sep 2005

Scintigraphy scan may help clinicians properly diagnose and then treat two forms of cardiac amyloidosis

"Clinically, this finding helps differential diagnosis and reduces the risk of misdiagnosis between two conditions with very different therapeutic options," said Claudio Rapezzi, M.D. from the University of Bologna and S. Orsola-Malpighi Hospital in Bologna, Italy.

21 Sep 2005

Combining radiation, chemotherapy and liver transplantation increases survival in bile duct cancer patients

A new treatment for patients with a type of bile duct cancer promises a greater chance at survival by combining radiation, chemotherapy and liver transplantation, Mayo Clinic physicians report in the September issue of the Annals of Surgery.

12 Sep 2005