Pathophysiology News and Research

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Study findings highlight importance of early detection of SMA through newborn screening

Spinal muscular atrophy is a genetic disease that affects motor neurons in the spinal cord, resulting in muscle atrophy and widespread weakness that eventually impair swallowing and breathing.

17 Jul 2018

NeuroTrauma Sciences and Henry Ford join hands to advance exosome technology

NeuroTrauma Sciences, LLC, a biopharmaceutical company, and Henry Ford Health System, a non-profit organization, today announce that a newly-formed subsidiary of NTS has entered into multi-year Sponsored Research and License Agreements.

16 Jul 2018

Study elucidates pathophysiology of systemic lupus erythematosus

Osaka University researchers elucidated the pathophysiology of systemic lupus erythematosus, an autoimmune disorder that causes inflammation and tissue damage.

11 Jul 2018

Starting physical therapy earlier may benefit adolescents with concussion

For adolescents with symptoms following a concussion, starting physical therapy (PT) earlier - within less than three weeks after the injury - provides outcomes similar to those of later PT, suggests a study in the July issue of The Journal of Neurologic Physical Therapy.

27 Jun 2018

Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer's disease

Two strains of human herpesvirus-;human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) -;are found in the brains of people with Alzheimer's disease at levels up to twice as high as in those without Alzheimer's, researchers from the Icahn School of Medicine at Mount Sinai report.

21 Jun 2018

Multidisciplinary Human-Focused Research

The work that we're doing in particular involves the development of better models of the human body. To do that, we need to put together cells, tissues, culture them in an artificial environment so that they feel as if they're inside the human body.

From Logos Biosystems 20 Jun 2018

Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases

A new study by Professors Martti Juhola and Katriina Aalto-Setälä of the University of Tampere in Finland demonstrates that with the use of artificial intelligence and machine learning, it is possible not only to accurately sort sick cardiac cell cultures from healthy ones, but also to differentiate between genetic cardiac diseases.

20 Jun 2018

Novel chip can be used to identify rhinovirus strains as cause of asthma

MedUni Vienna has developed a method that can be used to identify individual rhinovirus strains ("cold viruses") as a cause of asthma.

18 Jun 2018

Studies provide insight into molecular changes prior to onset of arthritis

The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) provide insight into molecular changes prior to the onset of arthritis which could inform future novel diagnostics and early therapeutic interventions.

18 Jun 2018

Study finds gender differences in pathophysiology of Parkinson's disease

Not only do women appear to be better protected than men from Parkinson's disease, the associated pathophysiology also shows gender differences. This is a finding of a study from Slovenia, presented at the Congress of the European Academy of Neurology in Lisbon.

18 Jun 2018

Cleveland Clinic receives $3.7 million grant from AHA for atrial fibrillation research

The American Heart Association has awarded Cleveland Clinic a $3.7 million grant for atrial fibrillation research. The four-year, competitive award will support three synergistic projects aimed at improving outcomes for patients with atrial fibrillation, a common heart rhythm abnormality.

13 Jun 2018

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase for the treatment of Primary Hyperoxaluria Type 1.

8 Jun 2018

International experts agree on need for human-relevant research to improve drug discovery

The average pre-approval cost of research and development for a successful drug is estimated to be US$2.6 billion and the number of new drugs approved per billion US dollars spent has halved roughly every 9 years since 1950.

8 Jun 2018

Classifying heart failure patients based on redox status may help personalize treatment

For more than six decades, oxidative stress has been linked to heart failure, a progressive weakening of the heart muscle that can lead to death. While antioxidant supplements such as vitamin C, vitamin B and beta-carotene have been widely used in heart failure, they often prove ineffective.

6 Jun 2018