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Study finds patients treated with varespladib drug more likely to experience cardiovascular events

Patients with acute coronary syndrome who were treated with the experimental drug varespladib were more likely to experience additional cardiovascular events - including sudden death, heart attack and stroke - than those treated with placebo, according to research from the Cleveland Clinic Coordinating Center for Clinical Research (C5Research).

19 Nov 2013

Findings may help scientists better understand prognosis of advanced prostate cancer

Many patients diagnosed with prostate cancer have indolent, slow-growing forms of the disease that are not life-threatening. However, more than 30,000 American men will die from aggressive prostate cancer this year alone. This sharp contrast between low-risk and aggressive disease presents a challenge for many researchers and physicians as they diagnose patients and also determine the prognosis of the men with the most aggressive forms of prostate cancer.

19 Nov 2013

Researchers solve structure of key protein in Nipah virus

What began as a summer internship project designed for an undergraduate student evolved into a one-year study of one of the deadliest, but little known viruses.

18 Nov 2013

Scientists describe interplay of four molecules that trigger, govern antibody production in immune cells

Australian scientists have described an exquisitely balanced interplay of four molecules that trigger and govern antibody production in immune cells. As well as being an important basic science discovery, it helps explain why people with mutations in any one of the associated genes cannot fight infection effectively, and develop rare and crippling immunodeficiency disorders.

18 Nov 2013

Mount Sinai biologist wins NIH Director's New Innovator Awards for High-Risk, High Reward Research

Arvin Dar, PhD, structural and chemical biologist in oncological sciences at the Icahn School of Medicine at Mount Sinai, is one of 41 national recipients of the prestigious National Institutes of Health (NIH) Director's New Innovator Awards for High-Risk, High Reward Research. The award will support Dar's research into Ras-dependent cancers, specifically investigating how to combat mutations in Ras, a protein implicated in at least one of every five cancers.

16 Nov 2013

Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound and re-establish the skin's layer of protection.

16 Nov 2013

Bleach solution could provide new way to treat skin damage

Processes that age and damage skin are impeded by dilute bleach solution, according to a new study by researchers at the Stanford University School of Medicine.

16 Nov 2013

MGH investigators identify molecule that plays key role in the breakdown of kidney filter

One of the most devastating side effects of diabetes is kidney failure, and one of the earliest signs of kidney damage is a disruption of the organ's filtering capacity. Diabetes patients who develop kidney failure must go on dialysis, seriously limiting their quality of life and placing them at significantly increased risk of death. The incidence of kidney disease is increasing with rising rates of obesity-associated type 2 diabetes, but very little progress has been made towards protecting the kidney's filter barrier during the past 50 years.

16 Nov 2013

WuXi PharmaTech subsidiary enters into supply arrangement with Pharmacyclics

WuXi PharmaTech, a leading pharmaceutical, biotechnology and medical device research and development outsourcing company with operations in China and the United States, today announced that its wholly owned subsidiary Shanghai SynTheAll Pharmaceutical Co., Ltd., has entered into a supply arrangement with Pharmacyclics, Inc.

15 Nov 2013

Copper intake via food and water can accelerate growth of tumors

Copper imbalances have been associated with a number of pathological conditions, including cancer. Publishing in PNAS scientists at EPFL have found that copper in drinking water - given at the maximum levels permitted in public water supplies - accelerated the growth of tumors in mice. On the other hand, reducing copper levels reduced tumor growth.

15 Nov 2013

Researchers exploit power of evolution to create new drug for use against heart disease

An international team of researchers led by the University of Leicester has "harnessed the power of evolution" to create a new drug for possible use against heart disease, inflammation and other illnesses.

15 Nov 2013

Small molecule compound shows significant success in controlling polyomaviruses

A team of scientists reports that a small molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened.

15 Nov 2013

Cells sticking molecule over-produced in rheumatoid arthritis and cancers

A molecule that helps cells stick together is significantly over-produced in two very different diseases - rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study. The scientists who made the discovery also found candidate drugs to inhibit the molecule, cadherin-11, one of which is already in a clinical trial.

14 Nov 2013

CD137 T cell activation molecule can help identify rare antitumor T cells in human cancers

Patients with tumors that contain increased numbers of T lymphocytes generally survive longer than those with tumors without T-cell involvement, suggesting that T cells with potent antitumor function naturally exist in cancer and control tumor progression. With the exception of melanoma, it has been difficult to identify and isolate the tumor-reactive T cells from common cancers, however, the ability to do so could be used to fight a patient's own cancer.

14 Nov 2013

FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

FibroGen, Inc. (FibroGen), today announced that data from a China-based Phase 2 study of roxadustat (FG-4592), a first-in-class oral compound in late stage development for the treatment of anemia associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), were presented in an oral session at the 2013 American Society of Nephrology (ASN) Kidney Week in Atlanta, Georgia.

13 Nov 2013

Neuroptis Biotech reports positive results from ML7 preclinical trials for eye surface diseases

Neuroptis Biotech, the ophthalmology drug research and development specialist, announces positive results in preclinical trials of the eye-drop formulation of its ML7 product. ML7 is intended for use in the treatment of eye surface diseases, particularly dry eye.

13 Nov 2013

New view can give scientists better understanding of how antidepressants work in human brain

Research from Oregon Health & Science University's Vollum Institute, published in the current issue of Nature, is giving scientists a never-before-seen view of how nerve cells communicate with each other.

13 Nov 2013

Father's cocaine use may make sons less sensitive to drug and more likely to resist addictive behaviors

A father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

12 Nov 2013

Research: New mechanisms and areas of brain linked with anxiety and depression

Research released today reveals new mechanisms and areas of the brain associated with anxiety and depression, presenting possible targets to understand and treat these debilitating mental illnesses.

12 Nov 2013

Researchers discovers key genetic culprit responsible for growth, metastasis of colon cancer

Chronic inflammation has long been known as a key risk factor for cancer---particularly colon cancer---but the exact mechanisms of how inflammation heightens the immune response, and ultimately influences the initiation and progression of cancer have remained elusive.

12 Nov 2013

Molecule News and Research

Study finds patients treated with varespladib drug more likely to experience cardiovascular events

Findings may help scientists better understand prognosis of advanced prostate cancer

Researchers solve structure of key protein in Nipah virus

Scientists describe interplay of four molecules that trigger, govern antibody production in immune cells

Mount Sinai biologist wins NIH Director's New Innovator Awards for High-Risk, High Reward Research

Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Bleach solution could provide new way to treat skin damage

MGH investigators identify molecule that plays key role in the breakdown of kidney filter

WuXi PharmaTech subsidiary enters into supply arrangement with Pharmacyclics

Copper intake via food and water can accelerate growth of tumors

Researchers exploit power of evolution to create new drug for use against heart disease

Small molecule compound shows significant success in controlling polyomaviruses

Cells sticking molecule over-produced in rheumatoid arthritis and cancers

CD137 T cell activation molecule can help identify rare antitumor T cells in human cancers

FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

Neuroptis Biotech reports positive results from ML7 preclinical trials for eye surface diseases

New view can give scientists better understanding of how antidepressants work in human brain

Father's cocaine use may make sons less sensitive to drug and more likely to resist addictive behaviors

Research: New mechanisms and areas of brain linked with anxiety and depression

Researchers discovers key genetic culprit responsible for growth, metastasis of colon cancer

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

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