Pathophysiology News and Research

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New finding demonstrates what happens at cellular level during onset of type2 diabetes

Researchers at Dublin City University and their project partners in the EU FP7 funded DEXLIFE project have found fresh evidence to explain the processes that occur in the body's cells leading to the onset of type2 diabetes.

12 Dec 2017

LSUHealthNO breakthrough may pave way for advances in obesity-related diseases

For the first time, researchers led by Frank Lau, MD, Assistant Professor of Clinical Surgery at LSU Health New Orleans, have successfully kept white fat tissue alive outside of the body for up to eight weeks.

11 Dec 2017

Smartphone addiction may be responsible for an imbalance in the brain, study says

A new study presented yesterday at the annual meeting of the Radiological Society of North America (RSNA) identified an imbalance in the brain chemistry of young people who are addicted to smartphones and the internet.

1 Dec 2017

UNIGE scientists unravel key role played by the liver in onset of type-2 diabetes

Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type-2 diabetes.

28 Nov 2017

Trial shows apple allergen as effective treatment option for birch pollen-related apple allergy

The food allergy, which is related to birch pollen, is a very common attendant phenomenon associated with birch pollen allergy - indeed around 70% of those with a birch pollen allergy are also allergic to apples. That amounts to around 280,000 people in Austria.

20 Nov 2017

Genotype may help identify patients at increased risk for sickle cell disease-related complications

Researchers have found a genotype that could help identify sickle cell disease (SCD) patients at greatest risk of common, yet severe, complications of SCD.

7 Nov 2017

Scientists identify eight new genes involved in epileptic encephalopathy

Approximately 30 per cent of patients with epilepsy do not respond to anti-epileptic drugs. In these cases, all neurologists can do is attempt to find the right combination of medication through trial and error.

6 Nov 2017

MRI scans of healthy military recruits reveal sacroiliac joint damage that mimics axial spondyloarthritis

The magnetic resonance imaging scans of healthy military recruits showed sacroiliac joint damage similar to that found in axial spondyloarthritis after just six weeks of intensive physical training, reinforcing the importance of exercising caution when interpreting MRI results, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego.

6 Nov 2017

Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease-; and new research on preventing and reversing its deadly consequences.

1 Nov 2017

Study links signs of heightened arousal in PTSD to overactivity of locus coeruleus

A new study in Biological Psychiatry has linked signs of heightened arousal and reactivity -- a core symptom of posttraumatic stress disorder (PTSD) -- to overactivity of the locus coeruleus (LC), a brain region that mediates arousal and reactivity. By combining bodily responses and brain imaging data, the new paper by Dr. Christoph Mueller-Pfeiffer at the University of Zurich, Switzerland and colleagues is the first to provide direct human evidence for a theory over 30 years old.

31 Oct 2017

Researchers find link between disrupted energy production and late-onset Alzheimer's disease

A team of investigators from McLean Hospital and Harvard Medical School, led by Kai C. Sonntag, MD, PhD, and Bruce M. Cohen, MD, PhD, has found a connection between disrupted energy production and the development of late-onset Alzheimer's disease (LOAD). The findings appear in the current issue of Scientific Reports.

27 Oct 2017

Study reveals how NET intervention can alleviate stress from traumatic cancer-related memories

Patients diagnosed and treated for a long-term potentially fatal diseases such as cancer, can accumulate distressing and traumatic experiences along the way.

27 Oct 2017

New molecule could become first treatment against chemotherapy-induced neuropathy

IDIBELL Researchers of the Neuro-Oncology Unit of Bellvitge University Hospital - Catalan Institute of Oncology, led by Dr. Jordi Bruna, have successfully tested a new molecule capable of preventing the development of peripheral neuropathy induced by chemotherapy in cancer patients, especially in colon cancer cases, the third most common neoplasm in the world.

24 Oct 2017

Crown Bioscience announces availability of new translational models for obesity and diabetes in Europe

Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International and a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, announces the availability of their proprietary FATZO model in a European based laboratory.

12 Oct 2017

Cellular messaging mechanism could lead to new way of treating disease

A newly discovered cellular messaging mechanism could lead to a new way to deliver therapeutics to tissues affected by disease, according to a new study from Harvard T.H. Chan School of Public Health.

27 Sep 2017

Study may contribute to genetic understanding of high-altitude adaptation

Many research groups have recently explored human adaptation and successfully identified candidate genes to high altitude living among three major far-flung global populations: Tibetans, Ethiopians and Peruvians.

22 Sep 2017

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now.

21 Sep 2017

Could smart vital sign monitoring provide an early warning system for hospitals?

Vital signs have been around for a long period of time. Taking the pulse is probably one of the oldest examinations that doctors have made to assess patients.

21 Sep 2017

Crohn's & Colitis Foundation and Oxford University Press partner to publish Inflammatory Bowels Diseases journal

The Crohn's & Colitis Foundation and Oxford University Press announced today that they have entered into a new partnership to publish the Foundation's journal Inflammatory Bowels Diseases beginning in 2018.

20 Sep 2017

Link between breast cancer and obesity may be more complex than previously thought

Obese women with large bellies may be at risk of developing a different subtype of breast cancer than those with widespread fat accumulation, according to a new study published in The Oncologist. This suggests that the link between breast cancer and obesity may be more complex than previously thought.

18 Sep 2017