Antiviral Drug News and Research

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Researchers detail molecular images of a piece of the spike-shaped protein that the SARS virus uses initiate the first stages of infection

Researchers have determined the first detailed molecular images of a piece of the spike-shaped protein that the SARS virus uses to grab host cells and initiate the first stages of infection.

19 Sep 2005

RNAi therapeutic successful for treatment of SARS respiratory virus in Rhesus Macaque

Intradigm Corporation announced today its collaboration with Chinese academic and biotech groups has achieved clear evidence of prophylactic and therapeutic effects of siRNA (small interfering RNA) agents in Rhesus monkey to treat SARS coronavirus (SCV) respiratory infection.

12 Sep 2005

Amantadine resistant avian influenza viruses more common in Southeast Asia than North America

Resistance to the antiviral drug amantadine is spreading more rapidly among avian influenza viruses of H5N1 subtype in Southeast Asia than in North America, according to the study done by investigators at St. Jude Children's Research Hospital.

12 Sep 2005

Design of wide-spectrum inhibitors targeting coronavirus main proteases

Coronaviruses - the family of viruses that causes the common cold - gained widespread recognition when the deadly severe acute respiratory syndrome, familiarly known as SARS, killed at least 800 people in 2003.

6 Sep 2005

Immunity - another important function of the mitochondria

Researchers have discovered a surprise lurking inside mitochondria, the power plants that are present in every cell. It turns out that these powerhouses also contain a protein that triggers the immune system to attack viral invaders.

28 Aug 2005

Drug company donates bird flu vaccine to World Health Organization

A donation by Swiss drug maker Roche, of enough of its Tamiflu antiviral drug to treat 3 million people against birdflu, could slow the spread of the outbreak among humans, especially in countries too poor to afford their own stockpile.

24 Aug 2005

Newly discovered virus linked to childhood respiratory infections

A team of Swedish researchers say they have identified a previously unknown virus that may cause many cases of serious respiratory infections in children.

23 Aug 2005

C. elegans has similar virus-fighting mechanism as humans and can be used in research

Researchers at the University of California, Riverside have discovered that a simple worm, called C. elegans, makes an excellent experimental host for studying some of the most virulent viruses that infect humans.

17 Aug 2005

Combined gene therapy eliminates glioblastoma multiforme in lab studies

Despite aggressive treatment, glioblastoma multiforme (GBM) - the most common and deadly of brain cancers - usually claims the lives of its victims within six to 12 months of diagnosis. Because GBM is so aggressive, the disease has been the target of a number of laboratory and clinical studies investigating the effectiveness of gene therapy to deliver novel therapies to the brain.

15 Aug 2005

U.S. company wants to commercialise breast milk

It has long been acknowledged that breast milk, with its minerals, digestive enzymes and antibodies, keeps babies healthy and boosts their intelligence.

7 Aug 2005

Scientists have a plan to prevent bird flu pandemic

According to scientists the H5N1 strain of bird flu circulating in Asia which could mutate into a lethal strain and cause a pandemic, could be contained.

4 Aug 2005

Containment of a Southeast Asian outbreak of avian influenza in humans may be possible

Though quick to caution about the many things that could go wrong, researchers say that it may be possible to contain a Southeast Asian outbreak of avian influenza in humans, buying precious time for the production of a vaccine.

3 Aug 2005

Infectious diseases pose a serious threat to the nation's public health

Infectious diseases pose a serious threat to the nation's public health. Today, experts addressed key developments to the current and future outlook of infectious diseases, highlighting adolescent immunizations, outbreaks and epidemics of infectious diseases, antimicrobial resistance and new developments in HIV medicine, at a press conference sponsored by the National Foundation for Infectious Diseases (NFID).

27 Jul 2005

Analysis of the Phase I/II clinical trial of HIV drug candidate PA-457

V.I. Technologies (Vitex) and collaborators at the University at Buffalo's School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, today presented a detailed analysis of the Phase I/II clinical trial of its HIV drug candidate PA-457 at the 3rd International AIDS Society (IAS) Conference on HIV Pathogenesis and Treatment in Rio de Janeiro, Brazil.

26 Jul 2005

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

It's one of the most common viruses in America, and one that causes the most guilt and shame. It can get inside almost any kind of human cell, reproduce in vast numbers, and linger for years in the body, causing everything from recurrent genital blisters to sores around the mouth. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders.

24 Jul 2005

U.S. stockpile of anti-flu drugs is "totally inadequate"

The United States does not have nearly enough antiviral drugs on hand to fight a coming influenza pandemic, according to the Infectious Diseases Society of America (IDSA).

19 Jul 2005

FDA fast tracks HIV protease inhibitor from Vertex and GSK

Vertex Pharmaceuticals has announced that its collaborator, GlaxoSmithKline (GSK), has received fast track designation for the HIV protease inhibitor (PI) 640385 (VX-385) from the United States Food and Drug Administration.

19 Jul 2005

Tamiflu may treat avian flu virus

Experiments in mice show that an antiviral drug currently used against annual influenza strains also can suppress the deadly influenza virus that has spread from birds to humans, killing dozens of people in Vietnam, Cambodia and Thailand since early 2004.

18 Jul 2005

The bird flu situation in many Asian countries remains critical

The bird flu situation in many Asian countries remains critical and requires more attention by affected countries and the international community, the UN Food and Agriculture Organization (FAO) has said.

6 Jul 2005

Plan designed to reduce the risk of the H5N1 avian influenza

International animal and human health experts today unveiled a multi-point plan designed to reduce the risk of the H5N1 avian influenza virus spreading from poultry to humans, and appealed to the international community to come forward with funds to make it work and help stave off the risk of an influenza pandemic.

6 Jul 2005