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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology.

6 Jul 2005

A new method for manipulating macromolecules

The technique uses double-stranded DNA to direct the behavior of other molecules. In previous DNA nanotechnology efforts, duplex DNA has been used as a static lattice to construct geometrical objects in three dimensions.

29 Jun 2005

Scientists solve structure of a critical innate immune system protein

Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs).

27 Jun 2005

Technique called phylogenetic footprinting reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication - and they did it solely by computer keystrokes and mouse clicks.

27 Jun 2005

Study challenges understanding of how messenger RNAs are translated into proteins

Our understanding of how messenger RNAs are translated into proteins is challenged by a new study published in the Open Access journal Journal of Biology.

27 Jun 2005

Researchers discover how microRNA are involved in the development of heart muscle

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle.

12 Jun 2005

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Using targeted RNA interference, or RNAi libraries, researchers at Harvard Medical School describe the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apoptosis and cell survival. This study appears in the June issue of Nature Cell Biology.

10 Jun 2005

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Researchers at Johns Hopkins have uncovered how a majority of the genetic changes in the hepatic-C virus, the most common cause of liver disease, allow it to evade the body's immune system during infection.

10 Jun 2005

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

9 Jun 2005

New study shows tiny RNAs intimately associated with cancer

In discoveries that may open a new chapter in understanding and diagnosing cancer, Howard Hughes Medical Institute (HHMI) investigators and their colleagues have established that tiny microRNAs provide a novel genetic route to the initiation of some forms of cancer.

9 Jun 2005

New understanding of microRNAs

Ribonucleic acid, or RNA, has long been thought to be important only to translate a gene's DNA into the proteins that are cells' workhorses. But new evidence shows that tiny bits of RNA not used to make proteins actually play central roles in normal biology and in the development of cancers.

8 Jun 2005

Research shows how a virus uses the gene silencing machinery for its own infectious purposes

In the latest version of the hide-and-seek game between pathogens and the hosts they infect, researchers have found that a virus appears to cloak itself with a recently discovered gene silencing device to evade detection and destruction by immune cells.

3 Jun 2005

Scientists shed new light on how protein Ro creates RNA quality control system for cells

A report by Yale scientists in the journal Cell sheds new light on how the protein Ro, a major autoantigen in patients with autoimmune disease, recognizes misfolded RNAs, creating a RNA quality control system for cells.

1 Jun 2005

Targeted Genetics issued patent related to adeno-associated virus (AAV) technology platform

Targeted Genetics Corporation has announced the issuance of another patent related to the Company's leading adeno-associated virus (AAV) technology platform. U.S. patent #6,897,045, titled "Adeno-Associated Virus Vectors," was issued to the University of Iowa Research Foundation and is exclusively licensed to Targeted Genetics.

30 May 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Is winter flu worse because of exercise-induced 'window of susceptibility'?

When you exercise or work outside in winter, that dry feeling at the back of your throat indicates the cold air has irritated your throat. Racehorses share a similar experience: exercising in below-freezing air causes mild airway injury.

26 May 2005

WIN compound - a prototype drug for curing colds - is showing so much promise

An antiviral compound that wiggles its way into the common cold virus may provide one piece of the solution to halting the infection, say Purdue University scientists.

25 May 2005

Gene keeps neural cells on correct developmental path

23 May 2005

Gene keeps neural cells on correct developmental path

Embryonic stem cells with identical genomes grow into distinctive tissues, such as heart, bone, and brain. At one time, scientists believed the differences among cell types arose from various sets of genes switched on inside developing cells. Then, studies showed that adult neurons uniquely lack a protein that permanently turns off neuronal genes in the rest of the body's cells.

20 May 2005

Researchers find first gene for inherited testicular cancer in mice

In this week's journal Nature, researchers report finding the first gene responsible for inherited susceptibility of testicular cancer in mice. The Ter mutation occurs in a gene called dead end, which is involved in normal testicular development and which may play a role in inherited forms of a testicular cancer occurring in infants.

20 May 2005

RNA News and Research

Further Reading

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

A new method for manipulating macromolecules

Scientists solve structure of a critical innate immune system protein

Technique called phylogenetic footprinting reveals new gene regulation system

Study challenges understanding of how messenger RNAs are translated into proteins

Researchers discover how microRNA are involved in the development of heart muscle

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

New study shows tiny RNAs intimately associated with cancer

New understanding of microRNAs

Research shows how a virus uses the gene silencing machinery for its own infectious purposes

Scientists shed new light on how protein Ro creates RNA quality control system for cells

Targeted Genetics issued patent related to adeno-associated virus (AAV) technology platform

Technology for analyzing gene expression must be standardized

Is winter flu worse because of exercise-induced 'window of susceptibility'?

WIN compound - a prototype drug for curing colds - is showing so much promise

Gene keeps neural cells on correct developmental path

Gene keeps neural cells on correct developmental path

Researchers find first gene for inherited testicular cancer in mice

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

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