Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

Study links cell size with commitment to division

How does a cell know when to divide? We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts.

24 May 2018

Tau mutations may serve as novel risk factor for cancer

Mutations to the protein tau, commonly associated with neurodegenerative disorders, may serve as a novel risk factor for cancer, according to results published in Cancer Research, a journal of the American Association for Cancer Research.

24 May 2018

Study provides blueprint of how fruit flies can be used to screen potentially pathogenic human genes

It all began with one young patient; a 7-year old boy who was born without a thymus, an important organ of the immune system, and without functional immune cells. The boy also presented with cardiac and skeletal defects, dysmorphic craniofacial features and some signs of autistic behaviors.

23 May 2018

Researchers push science one step closer to growing body parts in a lab

Researchers have learned that precursor cells for skeletal muscles actually also give rise to neurons, blood vessels, blood cells and immune cells, pushing science one step closer to generating body parts in a laboratory.

17 May 2018

Study uncovers mechanism underlying brain malformation linked to severe epilepsy

One of the most frequent causes of drug-resistant epilepsy, considered a difficult disease to control, is a brain malformation known as focal cortical dysplasia.

16 May 2018

Acetaminophen use helps reduce acute kidney injury risk in pediatric heart surgery patients

Children who underwent cardiac surgery were less likely to develop acute kidney injury if they had been treated with acetaminophen in the first 48 hours after their procedures, according to a Vanderbilt study just published in JAMA Pediatrics.

15 May 2018

Scientists uncover genome variation linked to increased risk of developing Alzheimer's

An article published in Nature Medicine with the collaboration of the research group of Dr. Manel Esteller, director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, ICREA Researcher and Professor of Genetics of the University of Barcelona, and Drs. Dave Monk and Isidre Ferrer, from the same center, shows that the inheritance of small changes in DNA alters the expression of the PM20D1 gene and is associated with an increased risk of developing Alzheimer's disease.

14 May 2018

New tool provides high accuracy and precision in analyzing disease and drug effects

A new protein analysis tool developed at the University at Buffalo could vastly increase the speed and precision with which disease and drug effects are analyzed.

11 May 2018

New model based on combination of GANs with reinforcement learning for drug discovery

Insilico Medicine, a Baltimore-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research announces the publication of a new research paper in Molecular Pharmaceutics journal titled "Adversarial Threshold Neural Computer for Molecular De Novo Design".

10 May 2018

Changing metabolic states of intestinal bacteria have an effect on MAIT defense cells

A little-explored group of immune cells plays an important role in the regulation of intestinal bacteria.

9 May 2018

Scientists develop computer algorithm that reveals gene networks activated in cancer cell

Recent headlines have cast suspicion on social network analysis, which can mine data from the internet to target advertisements or potentially influence elections.

9 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

Researchers use human and worm data to explore mutational causes of cancer

Researchers at the European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute have used human and worm data to explore the mutational causes of cancer.

2 May 2018

Insilico’s CEO to deliver presentation on “Artificial Intelligence for Aging Research”

Insilico Medicine, a Baltimore-based company specializing in the application of next-generation artificial intelligence for drug discovery, biomarker development and aging research, announces the presentation of its CEO, Alex Zhavoronkov, at the Pioneers 18 Conference, May 25, 2018, Vienna, Austria.

28 Apr 2018

Specific type of RNA editing plays key role in protein variation in cancer cells, shows research

A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many cancers, can vary from cancer to cancer and even patient to patient, a discovery that adds to a growing base of knowledge important for developing more effective precision therapies.

27 Apr 2018

New noninvasive technique uses blood test to detect brain tumor biomarkers

Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test.

26 Apr 2018

EPFL becomes part of Chan Zuckerberg’s project to develop Human Cell Atlas

"The automated single-cell analysis pipeline is a software tool that catalyzes interdisciplinary work as it allows non-expert labs to engage in high-level genomic research that otherwise would require significant computational expertise," explains Professor Bart Deplancke, director of a lab at EPFL's Institute of Bioengineering.

20 Apr 2018

Rare variants in non-coding DNA inherited from parents heighten autism risk

In recent years, researchers have firmly established that gene mutations appearing for the first time, called de novo mutations, contribute to approximately one-third of cases of autism spectrum disorder.

20 Apr 2018

UT Southwestern scientists discover protein linked to metastatic breast cancer

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.

18 Apr 2018

Scientists from Cure First and SEngine Precision Medicine discover common link in 28% of all cancers

Seattle scientists from Cure First, a non-profit research organization, and SEngine Precision Medicine, a biotech developing targeted, more effective, and less toxic cancer therapeutics, co-authored one of 27 high-profile papers published today by Cell Press.

13 Apr 2018