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The role body fat plays in determining one's risk of chronic diseases

As the prevalence of obesity in America approaches epidemic proportions, researchers are scrambling to learn more about how the body stores fat, how fat tissues affect body systems and the role body fat plays in determining one's risk of chronic diseases.

27 Jan 2005

VCU Gastroenterology research papers ranked 4th in most cited papers

Virginia Commonwealth University’s School of Medicine has been ranked fourth among federally funded U.S. universities based on the average number of citations per research paper published in indexed journals of gastroenterology and hepatology between 1999 and 2003.

26 Jan 2005

Painful surgical adhesions may be preventable by taking the COX-2 inhibitor Celebrex

Adhesions – bands of scar tissue that bind together two internal body surfaces – develop in 55 percent to more than 90 percent of patients undergoing surgery, depending on the type of operation. They are part of normal healing, but when surfaces fuse together that shouldn't, serious pain and complications can result.

26 Jan 2005

Local environment directly influences adult stem cell reservoirs

Using the common fruit fly, researchers at UT Southwestern Medical Center have discovered that an intricate set of signals released by stem cells' surroundings governs their maintenance.

26 Jan 2005

Priming embryonic stem cells to fulfill their promise

Bioengineering researchers at the University of California, San Diego have invented a process to help turn embryonic stem cells into the types of specialized cells being sought as possible treatments for dozens of human diseases and health conditions.

24 Jan 2005

Annual mammograms best for women who have been treated for early stage breast cancer

Annual mammograms and doctor visits are the best follow-up strategy for women who have been treated for early stage breast cancer, according to a new review of recent research.

24 Jan 2005

Severity of liver disease not a reliable indicator of quality of life

A new study on the determination of how livers are allocated for transplants examined the relationship between liver disease severity and quality of life, and found that the commonly used model for liver allocation is not a reliable indicator of general quality of life.

24 Jan 2005

New federal guidelines for the use of antiretroviral drugs to prevent HIV infection

The Centers for Disease Control and Prevention (CDC) today announced new federal guidelines for the use of antiretroviral drugs to prevent HIV infection after exposure to HIV through sexual intercourse, sexual assault, injection drug use, or accidents.

20 Jan 2005

10 million Americans have osteoporosis, and another 18 million have low bone mass

According to the National Osteoporosis Foundation, 10 million Americans have osteoporosis, and another 18 million have low bone mass, making them at risk for osteoporosis. Often referred to as the silent disease because it develops slowly over a number of years without symptoms, osteoporosis is characterized by a gradual weakening of the bones due to bone loss, which can lead to fractures.

20 Jan 2005

Mother’s diet and slimness might have long-term effects on the health of her baby

Researchers have discovered a link between the amount of blood flowing through the liver of the unborn baby in late pregnancy and the diet of expectant mums.

20 Jan 2005

Consumption of alcohol the risk of several common cancers

An article appearing in the Journal of Thrombosis and Haemostasis presents definite evidence of these findings amongst other papers as part of an open forum discussion on wine, alcohol, and cardiovascular risk.

19 Jan 2005

Role of ethnicity in nonalcoholic fatty liver disease

The first study to examine nonalcoholic fatty liver disease (NAFLD) among different ethnic and racial groups in the United States finds that Hispanics may be at a higher risk of developing the condition. The study is published in Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience.

19 Jan 2005

Sildenafil restores cognitive function in rats after liver failure

A study involving rats reveals the mechanism responsible for learning impairment due to liver failure and shows that sildenafil restores cognitive function.

19 Jan 2005

No to over the counter statin!

Last Friday an FDA expert panel voted overwhelmingly against the over-the-counter sale of Merck's cholesterol lowering drug Mevacor (lovastatin). Mevacor is one of a number of drugs known as "statins" which are widely considered to be the most effective drugs for the treatment of high cholesterol. Statins work by inhibiting a liver enzyme used in the manufacture of cholesterol.

17 Jan 2005

Major partnership with National Institute of Allergy and Infectious Diseases for Narhex Life Sciences

Australian drug specialist Narhex Life Sciences, has announced a partnership with one of the world’s foremost US medical research centres to evaluate its protease inhibitor Nar DG 35 Prodrug for its activity against Hepatitis C and SARS viruses.

12 Jan 2005

Using models to understand malaria

Malaria is one of the world's major killers. More than 500 million people live in epidemic regions and some 2 million - mostly children - die each year. And each year, drug resistance increases in the malarial parasite, Plasmodium falciparum, and the search for new treatments becomes more desperate.

12 Jan 2005

Elevated glucose levels and diabetes associated with a greater risk for cancer

New research involving more than one million people indicates that having high fasting serum glucose levels and diabetes are risk factors for several major cancers, according to a study in the January 12 issue of JAMA.

12 Jan 2005

Elevated blood sugar levels and diabetes are risk factors for developing several types of cancer and mortality

The researchers followed over 1.2 million Koreans for 10 years, tracking new cancer cases and deaths from cancer. Study participants with diabetes, as well as those without diabetes and higher fasting blood sugar levels, were more likely to develop cancer or to die from cancer.

11 Jan 2005

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus.

9 Jan 2005

Pegylated interferon alfa-2b offers the best treatment option for people with chronic hepatitis B infection

Harry Janssen (Erasmus University Medical Centre, Rotterdam, Netherlands) and colleagues assessed whether combination treatment with pegylated interferon alfa-2b and the antiviral agent lamivudine was more efficacious in treating chronic hepatitis B infection than pegylated interferon alfa-2b therapy alone.

7 Jan 2005

Liver News and Research

The role body fat plays in determining one's risk of chronic diseases

VCU Gastroenterology research papers ranked 4th in most cited papers

Painful surgical adhesions may be preventable by taking the COX-2 inhibitor Celebrex

Local environment directly influences adult stem cell reservoirs

Priming embryonic stem cells to fulfill their promise

Annual mammograms best for women who have been treated for early stage breast cancer

Severity of liver disease not a reliable indicator of quality of life

New federal guidelines for the use of antiretroviral drugs to prevent HIV infection

10 million Americans have osteoporosis, and another 18 million have low bone mass

Mother’s diet and slimness might have long-term effects on the health of her baby

Consumption of alcohol the risk of several common cancers

Role of ethnicity in nonalcoholic fatty liver disease

Sildenafil restores cognitive function in rats after liver failure

No to over the counter statin!

Major partnership with National Institute of Allergy and Infectious Diseases for Narhex Life Sciences

Using models to understand malaria

Elevated glucose levels and diabetes associated with a greater risk for cancer

Elevated blood sugar levels and diabetes are risk factors for developing several types of cancer and mortality

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Pegylated interferon alfa-2b offers the best treatment option for people with chronic hepatitis B infection

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