Antifungal News and Research

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Scientists uncover new method to produce compounds with anti-cancer properties

In the past decades, cancer has surpassed many other diseases to become the current second leading cause of death globally, with one in six people dying from it.

17 Nov 2020

Antifungal agent Itraconazole inhibits SARS CoV-2 in vitro

Itraconazole is a broad-spectrum antifungal agent that has been shown to have some in vitro activity against SARS-CoV-2 by a team of Belgian and German researchers.

16 Nov 2020

ERC Synergy project explores causes of drug tolerance in intractable fungal infections

Over the next six years, research groups at Charité - Universitätsmedizin Berlin and Tel Aviv University will study how invasive fungal pathogens are able to evade treatments and develop tolerance to antifungal drugs.

10 Nov 2020

Study finds wide variation in levels and anti-tumor effectiveness of a common cancer drug

When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients.

17 Sep 2020

Fungi can develop drug resistance without genetic changes

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs.

9 Sep 2020

As threat of valley fever grows beyond the Southwest, push is on for vaccine

One New Year's Day, Rob Purdie woke up with a headache that wouldn't quit. Vision problems, body aches and a slight fever followed. At the emergency room, the Bakersfield, California, resident was given antibiotics, which didn't touch his symptoms.

4 Sep 2020

High concentrations of toxic pollutants were detected in stranded whales, dolphins

A study led by researchers at Florida Atlantic University's Harbor Branch Oceanographic Institute examined toxins in tissue concentrations and pathology data from 83 stranded dolphins and whales along the southeastern coast of the United States from 2012 to 2018.

7 Aug 2020

Chemists discover a way to create synthetic version of natural anti-cancer compound

Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.

6 Aug 2020

Study shows how microbes influence the quality of sausage and other fermented foods

Microbes in "starter cultures" impart a distinctive tang and longer shelf life to food like sourdough bread, yogurt and kimchi through the process of fermentation.

6 Aug 2020

Three commercially available drugs may cause unexpected effects in humans, shows study

A new study of 1,443 medications found that three prescription drugs currently on the market caused unexpected changes in worms that could point to potential, unrecognized effects in humans.

28 Jul 2020

Neurotransmitter-derived lipidoids help carry drugs across the blood-brain barrier in mice

Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice.

24 Jul 2020

New fabrics prevent the transmission and spread of SARS-CoV-2

Brazilian textile companies have begun producing and marketing fabrics treated with silver and silica nanoparticles developed by the research groups at the Centre for Functional Materials (CDMF) and the Theoretical and Computational Chemistry Laboratory (QTC) at the Universitat Jaume I, in collaboration with the company Nanox Tecnologia, which provide the new fabrics with antibacterial, antifungal and antiviral properties with 99.99% effectiveness.

20 Jul 2020

New method spurs production of antibiotic or antiparasitic compounds in actinobacteria

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches.

25 Jun 2020

Researchers solve structure of key enzyme critical for biofilm formation in fungal pathogen

Aspergillus fumigatus is a species of fungus that can cause serious illnesses in immunocompromised individuals such as those who are undergoing transplantation or cancer chemotherapy.

17 Jun 2020

Genetic marker may predispose African Americans to cardiac complications from COVID-19

Nearly one out of every 10 African Americans has a genetic variant that puts them inherently at an increased risk for ventricular arrhythmias and sudden cardiac death.

15 Jun 2020

Immune modulation can cure severe and often fatal fungal infection in children

In the June 11 issue of the New England Journal of Medicine, a team of UCLA physicians and scientists describes the first case of immune modulation being used to cure a severe and often fatal fungal infection.

11 Jun 2020

New antibiotic guidelines could save more lives in intensive care units

More lives could be saved in intensive care units around the world if new antibiotic guidelines designed by The University of Queensland are adopted.

8 May 2020

New drug formulation could be used in the treatment of Candida infections

With antimicrobial resistance (AMR) increasing around the world, new research led by the University of Bristol has shown a new drug formulation could possibly be used in antifungal treatments against Candida infections.

28 Apr 2020

New database of 14,000 known macrolactones could support drug discovery and research

Researchers from North Carolina State University and Collaborations Pharmaceuticals have created a free-to-use database of 14,000 known macrolactones - large molecules used in drug development - which contains information about the molecular characteristics, chemical diversity and biological activities of this structural class.

22 Apr 2020

Analysis reveals cocktail of pharmaceuticals in the waters of Bangladesh

In spring of 2019, researchers set out to investigate what chemicals could be found in the waters of Bangladesh.

20 Apr 2020