Mutation News and Research

RSS

Roche files for application with FDA to market hepatitis C medication Pegasys(R) for chronic hepatitis B treatment

Roche announced today the submission of a supplemental new biologics license application (sBLA) with the U.S. Food and Drug Administration to market Pegasys(R) (peginterferon alfa-2a) for the treatment of chronic hepatitis B (CHB).

21 Jul 2004

Chemotherapy aimed at both cancer cells and their genetically normal cellular 'microenvironment' might improve the success of breast cancer treatment

In the first comprehensive survey of gene activity in each cell type composing normal and malignant breast tissue, scientists at Dana-Farber Cancer Institute have identified genes in non-cancerous supporting cells that can spur the growth of breast cancer cells.

20 Jul 2004

U.S. scientists have found the genetic basis for one form of sudden infant death syndrome

Sudden infant death syndrome, also known as cot death and crib death, is defined as the death of an infant between the ages of one month and one year which remains unexplained after a thorough postmortem, investigation of the death scene and review of the clinical history.

20 Jul 2004

New compound that is designed to overcome Gleevec resistance

One of the truly spectacular success stories in modern oncology is the development and implementation of Gleevec, a drug that virtually halts the progress of chronic myeloid leukemia. Yet for some patients who harbor particularly stubborn genetic mutations, Gleevec fails miserably.

17 Jul 2004

Online database of AIDS-related protein structures

Researchers who are either developing drug treatments for AIDS or studying the virus that causes the disease have a new resource - an online database of AIDS-related protein structures just unveiled for public use by the National Institute of Standards and Technology.

16 Jul 2004

The cancer risk from plutonium exposure

Plutonium may be many times more dangerous than previously thought. The cancer risk from exposure inside the body could be 10 times higher than is allowed for in calculating international safety limits.

15 Jul 2004

New hereditary spastic paraplegia research

In work reported this week, researchers have taken our understanding of HSP to a new level with the development of an animal model for the disease.

13 Jul 2004

Study evaluates effectiveness of LEXIVA/ritonavir and Lopinavir/ritonavir in protease inhibitor

HIV treatment regimens containing the protease inhibitor (PI) LEXIVA® (fosamprenavir calcium) dosed with ritonavir (LEXIVA/r) or lopinavir (LPV) and ritonavir (LPV/r) were effective in suppressing HIV in patients who had failed prior PI-containing regimens, according to information presented at the International AIDS Conference (IAC).

12 Jul 2004

Human antibodies that thwart the SARS virus in mice can be mass-produced quickly

Human antibodies that thwart the SARS virus in mice can be mass-produced quickly using a new laboratory technique developed by an international research team collaborating with the National Institute of Allergy and Infectious Diseases (NIAID).

12 Jul 2004

Genetic mutation is a major contributor to type 1 diabetes

A natural mutation of a gene that helps regulate the reactivity of the immune system is a major contributor to type 1 diabetes, Medical College of Georgia researchers have found.

12 Jul 2004

Cheap AIDS drugs may help prevent HIV in babies in Thailand

Aids is one of the principal causes of infant mortality in many developing countries. Viral transmission takes place during pregnancy (in utero), at the moment of childbirth or even during breastfeeding.

10 Jul 2004

Avian influenza virus in East Asia arose through a series of genetic reassortment events with other viruses

An avian influenza virus that has caused three major outbreaks among poultry and killed several people in East Asia over the past seven years arose through a series of genetic reassortment events with other viruses.

9 Jul 2004

Researchers shed new light on the function of huntingtin, the protein whose mutation underlies Huntington’s disease

CNRS and Inserm research scientists at the Institut Curie have shed new light on the function of huntingtin, the protein whose mutation underlies Huntington’s disease.

8 Jul 2004

Research could help disarm deadly retroviruses such as HIV or SARS

Taken to its ultimate outcome, the research that biology professor Dr. Steve Howard is working on could help disarm deadly retroviruses such as HIV or SARS.

7 Jul 2004

Key proteins that regulate neurofibromatosis could be targets for new drugs

More than 100,000 Americans suffer from the painful and debilitating genetic disorder known as neurofibromatosis, or NF, which causes tumors to grow in various types of nerve tissue throughout the body.

7 Jul 2004

Drinking lots of milk may lower the risk of colorectal cancer

Drinking lots of milk and increasing your calcium intake may lower the risk of colorectal cancer, according to a new study that appears in the July 7 issue of the Journal of the National Cancer Institute.

7 Jul 2004

How DNA repair machinery detects and corrects errors in DNA replication

Biochemists at Duke University Medical Center have discovered key components that enable the cell's DNA repair machinery to adeptly launch its action in either direction along a DNA strand to strip out faulty DNA.

2 Jul 2004

Children cured of acute lymphocytic leukemia after chemotherapy have a 5-20 times greater risk of developing secondary malignant neoplasm's

The alterations in the children's gene sequence remain embedded within their chromosomes and may pose elevated risk for development of second malignancies and other diseases later in life, cautioned Barry A. Finette, M.D., Ph.D., associate professor of pediatrics at the University of Vermont.

1 Jul 2004

By altering a single gene you could live longer and be thinner

Imagine that by altering the function of a single gene, you could live longer, be thinner and have lower cholesterol and fat levels in your blood.

30 Jun 2004

Geneticists have closed in on the genetic basis for risk factors of metabolic diseases

Oxford geneticists have closed in on the genetic basis for risk factors of metabolic diseases such as hypertension, obesity and diabetes.

30 Jun 2004

Mutation News and Research

Roche files for application with FDA to market hepatitis C medication Pegasys(R) for chronic hepatitis B treatment

Chemotherapy aimed at both cancer cells and their genetically normal cellular 'microenvironment' might improve the success of breast cancer treatment

U.S. scientists have found the genetic basis for one form of sudden infant death syndrome

New compound that is designed to overcome Gleevec resistance

Online database of AIDS-related protein structures

The cancer risk from plutonium exposure

New hereditary spastic paraplegia research

Study evaluates effectiveness of LEXIVA/ritonavir and Lopinavir/ritonavir in protease inhibitor

Human antibodies that thwart the SARS virus in mice can be mass-produced quickly

Genetic mutation is a major contributor to type 1 diabetes

Cheap AIDS drugs may help prevent HIV in babies in Thailand

Avian influenza virus in East Asia arose through a series of genetic reassortment events with other viruses

Researchers shed new light on the function of huntingtin, the protein whose mutation underlies Huntington’s disease

Research could help disarm deadly retroviruses such as HIV or SARS

Key proteins that regulate neurofibromatosis could be targets for new drugs

Drinking lots of milk may lower the risk of colorectal cancer

How DNA repair machinery detects and corrects errors in DNA replication

Children cured of acute lymphocytic leukemia after chemotherapy have a 5-20 times greater risk of developing secondary malignant neoplasm's

By altering a single gene you could live longer and be thinner

Geneticists have closed in on the genetic basis for risk factors of metabolic diseases

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Latest News